6E8P
CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49
Summary for 6E8P
| Entry DOI | 10.2210/pdb6e8p/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, (14beta,17beta)-estra-1(10),2,4,6,8-pentaene-3,17-diyl disulfamate, ... (4 entities in total) |
| Functional Keywords | carbonic anhydrase steroid sulfamate cancer, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29336.38 |
| Authors | Andring, J.T.,Mckenna, R. (deposition date: 2018-07-30, release date: 2019-04-03, Last modification date: 2023-10-11) |
| Primary citation | Andring, J.T.,Dohle, W.,Tu, C.,Potter, B.V.L.,McKenna, R. 3,17 beta-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity. J. Med. Chem., 62:2202-2212, 2019 Cited by PubMed: 30721041DOI: 10.1021/acs.jmedchem.8b01990 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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