PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

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8BUM	Structure of DDB1 bound to DS15-engaged CDK12-cyclin K 分子名称: (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-20 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU7	Structure of DDB1 bound to 21195-engaged CDK12-cyclin K 分子名称: 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.245 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUN	Structure of DDB1 bound to DS16-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU2	Structure of DDB1 bound to DS18-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUI	Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUA	Structure of DDB1 bound to 919278-engaged CDK12-cyclin K 分子名称: (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.193 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUR	Structure of DDB1 bound to DS50-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.64 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU4	Structure of DDB1 bound to DS22-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8B54	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 分子名称: 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2022-09-21 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161, 2023
3KCF	Crystal structure of TGFbRI complexed with a pyrazolone inhibitor 分子名称: 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3H-pyrazol-3-one, PHOSPHATE ION, TGF-beta receptor type-1 著者 Boriack-Sjodin, P.A. 登録日 2009-10-21 公開日 2009-12-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
8DGS	Cryo-EM structure of a RAS/RAF complex (state 1) 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Eck, M.J, Jeon, H, Park, E, Rawson, S. 登録日 2022-06-24 公開日 2023-07-05 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
8DGT	Cryo-EM structure of a RAS/RAF complex (state 2) 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Eck, M.J, Jeon, H, Park, E, Rawson, S. 登録日 2022-06-24 公開日 2023-07-05 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
8CAR	Discovery of the lanthipeptide Curvocidin and structural insights into its trifunctional synthetase CuvL 分子名称: NITRATE ION, PHOSPHATE ION, Serine/threonine protein kinase 著者 Martins, B.M, Sigurdsson, A, Duettmann, A.A, Jasyk, M, Dimos-Roehl, B, Schoepf, F, Gemander, M, Knittel, C.H, Schegotzki, R, Schmid, B, Kosol, S, Pommerening, L, Gonzalez-Viegas, M, Seidel, M, Huegelland, M, Leimkuehler, S, Dobbek, H, Mainz, A, Suessmuth, R. 登録日 2023-01-24 公開日 2023-06-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL. Angew.Chem.Int.Ed.Engl., 62, 2023
8BVW	RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) 分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... 著者 Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. 登録日 2022-12-20 公開日 2023-05-03 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
1XO2	Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin 分子名称: 3,7,3',4'-TETRAHYDROXYFLAVONE, Cell division protein kinase 6, Cyclin 著者 Lu, H.S, Chang, D.J, Baratte, B, Meijer, L, Schulze-Gahmen, U. 登録日 2004-10-05 公開日 2005-03-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin. J.Med.Chem., 48, 2005
1YM7	G Protein-Coupled Receptor Kinase 2 (GRK2) 分子名称: Beta-adrenergic receptor kinase 1 著者 Lodowski, D.T, Barnhill, J.F, Pyskadlo, R.M, Ghirlando, R, Sterne-Marr, R, Tesmer, J.J.G. 登録日 2005-01-20 公開日 2005-07-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 The role of Gbetagamma and domain interfaces in the activation of G protein-coupled receptor kinase 2 Biochemistry, 44, 2005
3KRW	Human GRK2 in complex with Gbetgamma subunits and balanol (soak) 分子名称: BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tesmer, J.J.G, Tesmer, V.M. 登録日 2009-11-19 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53, 2010
1ZMV	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant 分子名称: MAP/Microtubule affinity regulating kinase 2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2005-05-11 公開日 2006-02-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.105 Å) 主引用文献 Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure, 14, 2006
3KU2	Crystal Structure of inactivated form of CDPK1 from toxoplasma gondii, TGME49.101440 分子名称: Calmodulin-domain protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, UNKNOWN ATOM OR ION 著者 Wernimont, A.K, Artz, J.D, Finnerty, P, Xiao, T, He, H, Mackenzie, F, Sinestera, G, Hassani, A.A, Wasney, G, Vedadi, M, Lourido, S, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Sibley, D.L, Hui, R, Lin, Y.H, Structural Genomics Consortium (SGC) 登録日 2009-11-26 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat.Struct.Mol.Biol., 17, 2010
1ZRZ	Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota 分子名称: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, Protein kinase C, iota 著者 Messerschmidt, A, Macieira, S, Velarde, M, Baedeker, M, Benda, C, Jestel, A, Brandstetter, H, Neuefeind, T, Blaesse, M, Structural Proteomics in Europe (SPINE) 登録日 2005-05-23 公開日 2005-09-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif J.Mol.Biol., 352, 2005
1Y8G	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Inactive double mutant with selenomethionine 分子名称: MAP/Microtubule affinity-regulating kinase 2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2004-12-12 公開日 2006-02-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure, 14, 2006
3KRX	Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal) 分子名称: BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tesmer, J.J.G, Tesmer, V.M. 登録日 2009-11-19 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53, 2010
1ZMU	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type 分子名称: MAP/Microtubule affinity regulating kinase 2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2005-05-11 公開日 2006-02-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure, 14, 2006
2A19	PKR kinase domain- eIF2alpha- AMP-PNP complex. 分子名称: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ... 著者 Dar, A.C, Dever, T.E, Sicheri, F. 登録日 2005-06-19 公開日 2005-09-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
1ZMW	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant 分子名称: MAP/Microtubule affinity regulating kinase 2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2005-05-11 公開日 2006-02-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure, 14, 2006

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