2K2R
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![BU of 2k2r by Molmil](/molmil-images/mine/2k2r) | The NMR structure of alpha-parvin CH2/paxillin LD1 complex | 分子名称: | Alpha-parvin, Paxillin | 著者 | Wang, X, Fukuda, K, Byeon, I, Velyvis, A, Wu, C, Gronenborn, A, Qin, J. | 登録日 | 2008-04-10 | 公開日 | 2008-05-27 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The Structure of {alpha}-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly. J.Biol.Chem., 283, 2008
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2OT1
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![BU of 2ot1 by Molmil](/molmil-images/mine/2ot1) | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with naphthol AS-E phosphate, a competitive inhibitor | 分子名称: | Fructose-bisphosphate aldolase A, N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE | 著者 | St-Jean, M, Izard, T, Sygusch, J. | 登録日 | 2007-02-07 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with wiskott-Aldrich syndrome protein. J.Biol.Chem., 282, 2007
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6EG3
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![BU of 6eg3 by Molmil](/molmil-images/mine/6eg3) | Crystal structure of human BRM in complex with compound 15 | 分子名称: | 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2 | 著者 | Zhu, X, Kulathila, R, Hu, T, Xie, X. | 登録日 | 2018-08-17 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
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6EG2
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![BU of 6eg2 by Molmil](/molmil-images/mine/6eg2) | Crystal structure of human BRM in complex with compound 16 | 分子名称: | ISOPROPYL ALCOHOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea | 著者 | Zhu, X, Kulathila, R, Hu, T, Xie, X. | 登録日 | 2018-08-17 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
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3H8D
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![BU of 3h8d by Molmil](/molmil-images/mine/3h8d) | Crystal structure of Myosin VI in complex with Dab2 peptide | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, Disabled homolog 2, ... | 著者 | Yu, C, Feng, W, Wei, Z, Zhang, M. | 登録日 | 2009-04-29 | 公開日 | 2009-09-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Myosin VI undergoes cargo-mediated dimerization Cell(Cambridge,Mass.), 138, 2009
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1N99
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![BU of 1n99 by Molmil](/molmil-images/mine/1n99) | CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN | 分子名称: | Syntenin 1 | 著者 | Kang, B.S, Cooper, D.R, Jelen, F, Devedjiev, Y, Derewenda, U, Dauter, Z, Otlewski, J, Derewenda, Z.S. | 登録日 | 2002-11-22 | 公開日 | 2003-04-15 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | PDZ Tandem of Human Syntenin: Crystal Structure and Functional Properties Structure, 11, 2003
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3HIZ
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![BU of 3hiz by Molmil](/molmil-images/mine/3hiz) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. | 登録日 | 2009-05-20 | 公開日 | 2009-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
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4P9T
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![BU of 4p9t by Molmil](/molmil-images/mine/4p9t) | Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin | 分子名称: | 1,2-ETHANEDIOL, Catenin alpha-2, DI(HYDROXYETHYL)ETHER, ... | 著者 | Shibahara, T, Hirano, Y, Hakoshima, T. | 登録日 | 2014-04-04 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the free form of the N-terminal VH1 domain of monomeric alpha-catenin. Febs Lett., 589, 2015
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3HHM
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![BU of 3hhm by Molmil](/molmil-images/mine/3hhm) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin | 分子名称: | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. | 登録日 | 2009-05-15 | 公開日 | 2009-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
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5GJK
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![BU of 5gjk by Molmil](/molmil-images/mine/5gjk) | |
6KLT
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![BU of 6klt by Molmil](/molmil-images/mine/6klt) | Troponin of cardiac thin filament in low-calcium state | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ... | 著者 | Oda, T, Yanagisawa, H, Wakabayashi, T. | 登録日 | 2019-07-30 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin. J.Struct.Biol., 209, 2020
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6ICR
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![BU of 6icr by Molmil](/molmil-images/mine/6icr) | LdCoroCC mutant- C482A | 分子名称: | 1,2-ETHANEDIOL, Coronin-like protein | 著者 | Karade, S.S, Srivastava, V.K, Ansari, A, Pratap, J.V. | 登録日 | 2018-09-06 | 公開日 | 2019-10-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Molecular and structural analysis of a mechanical transition of helices in the L. donovani coronin coiled-coil domain. Int.J.Biol.Macromol., 143, 2020
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1IHQ
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![BU of 1ihq by Molmil](/molmil-images/mine/1ihq) | GLYTM1BZIP: A CHIMERIC PEPTIDE MODEL OF THE N-TERMINUS OF A RAT SHORT ALPHA TROPOMYOSIN WITH THE N-TERMINUS ENCODED BY EXON 1B | 分子名称: | CHIMERIC PEPTIDE GlyTM1bZip: TROPOMYOSIN ALPHA CHAIN, BRAIN-3 and GENERAL CONTROL PROTEIN GCN4 | 著者 | Greenfield, N.J, Yuang, Y.J, Palm, T, Swapna, G.V, Monleon, D, Montelione, G.T, Hitchcock-Degregori, S.E, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2001-04-19 | 公開日 | 2001-10-03 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric protein. J.Mol.Biol., 312, 2001
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1H6G
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![BU of 1h6g by Molmil](/molmil-images/mine/1h6g) | alpha-catenin M-domain | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ALPHA-1 CATENIN, CALCIUM ION, ... | 著者 | Yang, J, Dokurno, P, Tonks, N.K, Barford, D. | 登録日 | 2001-06-14 | 公開日 | 2001-08-07 | 最終更新日 | 2016-02-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of the M-Fragment of Alpha-Catenin: Implications for Modulation of Cell Adhesion. Embo J., 20, 2001
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1HHQ
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![BU of 1hhq by Molmil](/molmil-images/mine/1hhq) | Role of active site resiude Lys16 in Nucleoside Diphosphate Kinase | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE, SULFATE ION | 著者 | Schneider, B, Babolat, M, Xu, Y.W, Janin, J, Veron, M, Deville-Bonne, D. | 登録日 | 2000-12-26 | 公開日 | 2001-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mechanism of Phosphoryl Transfer by Nucleoside Diphosphate Kinase Ph-Dependence and Role of Active Site Lys16 and Tyr56 Residues Eur.J.Biochem., 268, 2001
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4ANJ
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![BU of 4anj by Molmil](/molmil-images/mine/4anj) | MYOSIN VI (MDinsert2-GFP fusion) PRE-POWERSTROKE STATE (MG.ADP.AlF4) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CALMODULIN, ... | 著者 | Menetrey, J, Isabet, T, Ropars, V, Mukherjea, M, Pylypenko, O, Liu, X, Perez, J, Vachette, P, Sweeney, H.L, Houdusse, A.M. | 登録日 | 2012-03-19 | 公開日 | 2012-10-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin Vi. Mol.Cell, 48, 2012
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4DID
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![BU of 4did by Molmil](/molmil-images/mine/4did) | |
7ATY
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![BU of 7aty by Molmil](/molmil-images/mine/7aty) | Solution NMR structure of the SH3 domain of human Caskin1 | 分子名称: | Caskin-1 | 著者 | Toke, O, Koprivanacz, K, Radnai, L, Mero, B, Juhasz, T, Liliom, K, Buday, L. | 登録日 | 2020-11-01 | 公開日 | 2021-02-03 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding. Cells, 10, 2021
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4JS0
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![BU of 4js0 by Molmil](/molmil-images/mine/4js0) | Complex of Cdc42 with the CRIB-PR domain of IRSp53 | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, Cell division control protein 42 homolog, ... | 著者 | Kast, D.J, Dominguez, R. | 登録日 | 2013-03-22 | 公開日 | 2014-03-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat.Struct.Mol.Biol., 21, 2014
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2KDG
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![BU of 2kdg by Molmil](/molmil-images/mine/2kdg) | Solution Structure of the 1st Ig domain of Myotilin | 分子名称: | Myotilin | 著者 | Heikkinen, O, Kilpelainen, I, Permi, P, Koskela, H, Ylanne, J, Carpen, O. | 登録日 | 2009-01-08 | 公開日 | 2009-07-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the first immunoglobulin domain of human myotilin J.Biomol.Nmr, 44, 2009
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5FFO
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![BU of 5ffo by Molmil](/molmil-images/mine/5ffo) | Integrin alpha V beta 6 in complex with pro-TGF-beta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, X, Zhao, B, Springer, T.A. | 登録日 | 2015-12-18 | 公開日 | 2017-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Force interacts with macromolecular structure in activation of TGF-beta. Nature, 542, 2017
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2AKA
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![BU of 2aka by Molmil](/molmil-images/mine/2aka) | Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus | 分子名称: | Dynamin-1, LINKER, myosin II heavy chain | 著者 | Reubold, T.F, Eschenburg, S, Becker, A, Leonard, M, Schmid, S.L, Vallee, R.B, Kull, F.J, Manstein, D.J. | 登録日 | 2005-08-03 | 公開日 | 2005-08-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the GTPase domain of rat dynamin 1. Proc.Natl.Acad.Sci.Usa, 102, 2005
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7MO1
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![BU of 7mo1 by Molmil](/molmil-images/mine/7mo1) | Crystal Structure of the ZnF1 of Nucleoporin NUP153 in complex with Ran-GDP | 分子名称: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNW
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![BU of 7mnw by Molmil](/molmil-images/mine/7mnw) | Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNZ
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![BU of 7mnz by Molmil](/molmil-images/mine/7mnz) | Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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