6PE0
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![BU of 6pe0 by Molmil](/molmil-images/mine/6pe0) | Msp1 (E214Q)-substrate complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Membrane-spanning ATPase-like protein, ... | 著者 | Wang, L, Myasnikov, A, Pan, X, Walter, P. | 登録日 | 2019-06-19 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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6PDY
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![BU of 6pdy by Molmil](/molmil-images/mine/6pdy) | Msp1-substrate complex in open conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Wang, L, Myasnikov, A, Pan, X, Walter, P. | 登録日 | 2019-06-19 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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6PDW
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![BU of 6pdw by Molmil](/molmil-images/mine/6pdw) | Msp1-substrate complex in closed conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Wang, L, Myasnikov, A, Pan, X, Walter, P. | 登録日 | 2019-06-19 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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6TAV
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![BU of 6tav by Molmil](/molmil-images/mine/6tav) | Crystal structure of endopeptidase-induced alpha2-macroglobulin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J. | 登録日 | 2019-10-30 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin Proc.Natl.Acad.Sci.USA, 2022
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2H3G
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8WU6
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![BU of 8wu6 by Molmil](/molmil-images/mine/8wu6) | Structure of a Nerylneryl Diphosphate Synthase from Solanum lycopersicum | 分子名称: | Nerylneryl diphosphate synthase CPT2, chloroplastic | 著者 | Li, F.R, Wang, Q.L, Pan, X.M, Dong, L.B. | 登録日 | 2023-10-20 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Discovery, Structure, and Engineering of a cis-Geranylfarnesyl Diphosphate Synthase. Angew.Chem.Int.Ed.Engl., 63, 2024
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8WU7
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![BU of 8wu7 by Molmil](/molmil-images/mine/8wu7) | Structure of a cis-Geranylfarnesyl Diphosphate Synthase from Streptomyces clavuligerus | 分子名称: | Isoprenyl transferase | 著者 | Li, F.R, Wang, Q.L, Pan, X.M, Dong, L.B. | 登録日 | 2023-10-20 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Discovery, Structure, and Engineering of a cis-Geranylfarnesyl Diphosphate Synthase. Angew.Chem.Int.Ed.Engl., 63, 2024
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7X80
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8QUG
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![BU of 8qug by Molmil](/molmil-images/mine/8qug) | KRAS-G12C in Complex with Compound 1 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Fischer, G, Kratochvil, B. | 登録日 | 2023-10-16 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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8WE6
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![BU of 8we6 by Molmil](/molmil-images/mine/8we6) | Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8WE8
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![BU of 8we8 by Molmil](/molmil-images/mine/8we8) | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8WE9
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![BU of 8we9 by Molmil](/molmil-images/mine/8we9) | Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
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8QVU
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![BU of 8qvu by Molmil](/molmil-images/mine/8qvu) | Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex | 分子名称: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A. | 登録日 | 2023-10-18 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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8QU8
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![BU of 8qu8 by Molmil](/molmil-images/mine/8qu8) | PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 | 分子名称: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Fischer, G, Peter, D, Arce-Solano, S. | 登録日 | 2023-10-14 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
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8B6Y
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8AZY
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![BU of 8azy by Molmil](/molmil-images/mine/8azy) | KRAS-G12D in complex with BI-2865 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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8AZR
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![BU of 8azr by Molmil](/molmil-images/mine/8azr) | KRAS in complex with precursor 1 | 分子名称: | (4~{S})-2-azanyl-4-[3-[6-[(2~{S})-2,4-dimethylpiperazin-1-yl]pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-4-methyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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8AZV
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![BU of 8azv by Molmil](/molmil-images/mine/8azv) | KRAS in complex with BI-2865 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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8AZX
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![BU of 8azx by Molmil](/molmil-images/mine/8azx) | KRAS-G12C in complex with BI-2865 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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8B00
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![BU of 8b00 by Molmil](/molmil-images/mine/8b00) | KRAS-G13D in complex with BI-2865 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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8AZZ
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![BU of 8azz by Molmil](/molmil-images/mine/8azz) | KRAS-G12V in complex with BI-2865 | 分子名称: | (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... | 著者 | Boettcher, J, Herdeis, L. | 登録日 | 2022-09-06 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | 主引用文献 | Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
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6NHW
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![BU of 6nhw by Molmil](/molmil-images/mine/6nhw) | Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer | 分子名称: | Tumor necrosis factor receptor superfamily member 10B | 著者 | Chou, J.J, Pan, L, Fu, Q, Zhao, L, Chen, W, Piai, A, Fu, T, Wu, H. | 登録日 | 2018-12-24 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell, 176, 2019
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6NHY
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![BU of 6nhy by Molmil](/molmil-images/mine/6nhy) | Structure of the transmembrane domain of the Death Receptor 5 mutant (G217Y) - Trimer Only | 分子名称: | Tumor necrosis factor receptor superfamily member 10B | 著者 | Chou, J.J, Pan, L, Zhao, L, Chen, W, Piai, A, Fu, T, Wu, H, Liu, Z. | 登録日 | 2018-12-24 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell, 176, 2019
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8U6X
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![BU of 8u6x by Molmil](/molmil-images/mine/8u6x) | ATP-dependent DNA ligase Lig E from Neisseria gonorrhoeae | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*CP*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), ... | 著者 | Williamson, A, Pan, J. | 登録日 | 2023-09-14 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation. Bmc Microbiol., 24, 2024
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2GWH
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![BU of 2gwh by Molmil](/molmil-images/mine/2gwh) | Human Sulfotranferase SULT1C2 in complex with PAP and pentachlorophenol | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, PENTACHLOROPHENOL, Sulfotransferase 1C2, ... | 著者 | Tempel, W, Pan, P.W, Dombrovski, L, Allali-Hassani, A, Vedadi, M, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2006-05-04 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and chemical profiling of the human cytosolic sulfotransferases. Plos Biol., 5, 2007
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