PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

---

8V7I	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s To Be Published
8V7C	Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7K	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s To Be Published
8V7A	Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7J	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s To Be Published
8V7F	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
8V7H	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7E	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ To Be Published
2DTU	Crystal structure of the beta hairpin loop deletion variant of RB69 gp43 in complex with DNA containing an abasic site analog 分子名称: 5'-D(*CP*GP*(3DR)P*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*GP*A)-3', DNA polymerase 著者 Aller, P, Hogg, M, Konigsberg, W, Wallace, S.S, Doublie, S. 登録日 2006-07-15 公開日 2006-12-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. J.Biol.Chem., 282, 2007
7N84	Double nuclear outer ring from the isolated yeast NPC 分子名称: Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ... 著者 Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. 登録日 2021-06-13 公開日 2022-01-26 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (11.6 Å) 主引用文献 Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
5ZYP	Structure of the Yeast Ctr9/Paf1 complex 分子名称: NICKEL (II) ION, RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1 著者 Xie, Y, Zheng, M, Zhou, H, Long, J. 登録日 2018-05-28 公開日 2018-09-26 最終更新日 2019-05-22 実験手法 X-RAY DIFFRACTION (2.532 Å) 主引用文献 Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
6YA5	2009 H1N1 PA Endonuclease in complex with LU2 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Radilova, K, Brynda, J. 登録日 2020-03-11 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. Eur.J.Med.Chem., 208, 2020
4JU1	Crystal structure of hcv ns5b polymerase in complex with compound 6 分子名称: 6-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-07-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
4JTW	Crystal structure of HCV NS5B polymerase in complex with coupound 1 分子名称: 1-(2,4,6-trifluorobenzyl)-6-[2-(trifluoromethyl)phenoxy]quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
2DY4	Crystal structure of RB69 GP43 in complex with DNA containing Thymine Glycol 分子名称: 5'-D(*CP*GP*(CTG)P*GP*GP*AP*AP*TP*GP*A*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*T*CP*AP*TP*TP*CP*CP*A)-3', DNA polymerase 著者 Aller, P, Rould, M.A, Hogg, M, Wallace, S.S, Doublie, S. 登録日 2006-09-06 公開日 2007-01-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc.Natl.Acad.Sci.USA, 104, 2007
5M6U	HUMAN PI3KDELTA IN COMPLEX WITH LASW1579 分子名称: 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 著者 Segarra, V, Hernandez, B, Lozoya, E, Blaesse, M, Hoeppner, S, Jestel, A. 登録日 2016-10-26 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8, 2017
4JTZ	Crystal structure of hcv ns5b polymerase in complex with compound 4 分子名称: 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-N-(pyridin-3-yl)-2-(trifluoromethyl)benzamide, GLYCEROL, Genome polyprotein, ... 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-07-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
4JU2	Crystal structure of hcv ns5b polymerase in complex with compound 12 分子名称: 6-[3-(pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-07-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
4JTY	Crystal structure of HCV NS5B polymerase with COMPOUND 2 分子名称: 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-2-(trifluoromethyl)benzamide, GLYCEROL, Genome polyprotein, ... 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-07-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
4GC7	Crystal structure of Dpo4 in complex with S-MC-dADP opposite dT 分子名称: CALCIUM ION, DNA (5'-D(*G*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... 著者 Eoff, R.L, Ketkar, A, Banerjee, S, Zafar, M.K. 登録日 2012-07-29 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry, 51, 2012
5XMA	Crystal structure of AsfvPolX in complex with DNA enzyme at P43212 space group 分子名称: DNA (36-MER), DNA/RNA (5'-D(*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*T)-R(P*G)-D(P*GP*GP*TP*GP*CP*GP*TP*TP*AP*CP*A)-3'), Repair DNA polymerase X 著者 Liu, H.H, Gan, J.H. 登録日 2017-05-13 公開日 2018-01-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Crystal structure of an RNA-cleaving DNAzyme. Nat Commun, 8, 2017
5GP1	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH 分子名称: NICKEL (II) ION, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, ... 著者 Zhang, C, Jin, T. 登録日 2016-07-30 公開日 2016-12-07 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.444 Å) 主引用文献 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design Biochem. Biophys. Res. Commun., 492, 2017
5GOZ	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH 分子名称: GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, PYROPHOSPHATE 2-, ... 著者 Zhang, C, Jin, T. 登録日 2016-07-30 公開日 2016-12-07 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.049 Å) 主引用文献 Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design Biochem. Biophys. Res. Commun., 492, 2017
1XSL	Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap 分子名称: 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ... 著者 Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C. 登録日 2004-10-19 公開日 2005-01-18 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A closed conformation for the Pol lambda catalytic cycle. Nat.Struct.Mol.Biol., 12, 2005
1XSP	Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate 分子名称: 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ... 著者 Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C. 登録日 2004-10-19 公開日 2005-01-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A closed conformation for the Pol lambda catalytic cycle. Nat.Struct.Mol.Biol., 12, 2005

<163164165166167168169170171172173174175176177178>