2DY4

Crystal structure of RB69 GP43 in complex with DNA containing Thymine Glycol

Summary for 2DY4

• Entry DOI: 10.2210/pdb2dy4/pdb
• Related: 1CLQ 1IG9 1Q9X 1Q9Y 1RV2 2DTU
• Descriptor: 5'-D(*CP*GP*(CTG)P*GP*GP*AP*AP*TP*GP*A*CP*AP*GP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*CP*TP*GP*T*CP*AP*TP*TP*CP*CP*A)-3', DNA polymerase, ... (4 entities in total)
• Functional Keywords: dna polymerase, dna lesion, thymine glycol, oxidative thymine lesion, transferase-dna complex, transferase/dna
• Biological source: Enterobacteria phage RB69
• Total number of polymer chains: 12
• Total formula weight: 463956.60

Authors

Aller, P.,Rould, M.A.,Hogg, M.,Wallace, S.S.,Doublie, S. (deposition date: 2006-09-06, release date: 2007-01-09, Last modification date: 2023-11-15)

• Primary citation: Aller, P.,Rould, M.A.,Hogg, M.,Wallace, S.S.,Doublie, S.; A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol.; Proc.Natl.Acad.Sci.USA, 104:814-818, 2007; PubMed: 17210917; DOI: 10.1073/pnas.0606648104

Experimental method

X-RAY DIFFRACTION (2.65 Å)