8X73
 
 | | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | | 分子名称: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | | 著者 | Zhang, H, Luo, C. | | 登録日 | 2023-11-22 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
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8X6Z
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8X6R
 | | KRasG12C in complex with inhibitor | | 分子名称: | 1-[7-[6-ethenyl-8-ethoxy-7-(5-methyl-1~{H}-indazol-4-yl)-2-(1-methylpiperidin-4-yl)oxy-quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | | 著者 | Amano, Y, Tateishi, Y. | | 登録日 | 2023-11-21 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg.Med.Chem., 98, 2023
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8X6M
 | | Crystal Structure of Glycerol Dehydrogenase in the Presence of NAD+ and Glycerol | | 分子名称: | GLYCEROL, Glycerol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Park, T, Kang, J.Y, Jin, M, Yang, J, Kim, H, Noh, C, Eom, S.H. | | 登録日 | 2023-11-21 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the octamerization of glycerol dehydrogenase.
Plos One, 19, 2024
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8X5V
 | | BlCas9-sgRNA-target DNA complex | | 分子名称: | 1,2-ETHANEDIOL, BlCas9, CHLORIDE ION, ... | | 著者 | Nakane, T, Nakagawa, R, Yamashita, K, Nishimasu, H, Nureki, O. | | 登録日 | 2023-11-19 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and engineering of Brevibacillus laterosporus Cas9.
Commun Biol, 7, 2024
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8X5M
 | | The Crystal Structure of JNK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide, GLYCEROL, ... | | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | | 登録日 | 2023-11-17 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Crystal Structure of JNK1 from Biortus.
To Be Published
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8X5L
 | | The Crystal Structure of PRKACA from Biortus. | | 分子名称: | (2S)-2-(4-chlorophenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)phenyl]ethanaminium, SODIUM ION, cAMP-dependent protein kinase catalytic subunit alpha | | 著者 | Wang, F, Cheng, W, Lv, Z, Lin, D, Pan, W. | | 登録日 | 2023-11-17 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The Crystal Structure of PRKACA from Biortus.
To Be Published
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8X5E
 | | Cryo-EM structure of human XPR1 in open state | | 分子名称: | PHOSPHATE ION, Solute carrier family 53 member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Jiang, D.H, Yan, R. | | 登録日 | 2023-11-17 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Structure of transport at 3.6 Angstroms resolution.
To Be Published
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8X4F
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8X3H
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8X38
 | | Crystal Structure of Decarboxylative Vanillate 1-Hydroxylase from Phanerochaete chrysosporium | | 分子名称: | ACETATE ION, Decarboxylative Vanillate 1-Hydroxylase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Suzuki, H, Mori, R, Ishida, T, Igarashi, K, Shimizu, M. | | 登録日 | 2023-11-12 | | 公開日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Decarboxylative Vanillate 1-Hydroxylase from Phanerochaete chrysosporium
To Be Published
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8X37
 | | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP | | 分子名称: | DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, Neryl-diphosphate synthase 1 | | 著者 | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | | 登録日 | 2023-11-12 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.
Chembiochem, 25, 2024
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8X36
 | | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form B) | | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | | 登録日 | 2023-11-12 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.
Chembiochem, 25, 2024
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8X35
 | | Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form A) | | 分子名称: | 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | | 登録日 | 2023-11-12 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.
Chembiochem, 25, 2024
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8X2U
 | | Radial spoke head-neck dimer | | 分子名称: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | | 著者 | Meng, X, Cong, Y. | | 登録日 | 2023-11-10 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia.
Nat Commun, 15, 2024
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8X2T
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8X2R
 | | The Crystal Structure of HSP 90-alpha from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-alpha | | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. | | 登録日 | 2023-11-10 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | The Crystal Structure of HSP 90-alpha from Biortus.
To Be Published
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8X2J
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8X2A
 | | The Crystal Structure of BMX from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, 4-[(3S)-3-{[(2E)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide, CHLORIDE ION, ... | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. | | 登録日 | 2023-11-09 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The Crystal Structure of BMX from Biortus.
To Be Published
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8X23
 | | The Crystal Structure of MAPK13 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Mitogen-activated protein kinase 13 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. | | 登録日 | 2023-11-09 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The Crystal Structure of MAPK13 from Biortus.
To Be Published
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8X1V
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8X1H
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8X1C
 | | Structure of nucleosome-bound SRCAP-C in the ADP-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. | | 登録日 | 2023-11-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
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8X19
 | | Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. | | 登録日 | 2023-11-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
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8X15
 | | Structure of nucleosome-bound SRCAP-C in the apo state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. | | 登録日 | 2023-11-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
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