7K8X
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![BU of 7k8x by Molmil](/molmil-images/mine/7k8x) | Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C121 Fab Heavy chain, C121 Fab Light chain, ... | 著者 | Abernathy, M.E, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8Q
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![BU of 7k8q by Molmil](/molmil-images/mine/7k8q) | Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C121 | 分子名称: | C121 Fab Heavy Chain, C121 Fab Light Chain, GLYCEROL | 著者 | Abernathy, M.E, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8Y
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![BU of 7k8y by Molmil](/molmil-images/mine/7k8y) | Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C121 Fab Heavy chain, C121 Fab Light chain, ... | 著者 | Abernathy, M.E, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7KDT
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![BU of 7kdt by Molmil](/molmil-images/mine/7kdt) | |
7K8P
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![BU of 7k8p by Molmil](/molmil-images/mine/7k8p) | |
7K8S
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![BU of 7k8s by Molmil](/molmil-images/mine/7k8s) | Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C002 Fab Heavy Chain, ... | 著者 | Barnes, C.O, Malyutin, A.G, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8R
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![BU of 7k8r by Molmil](/molmil-images/mine/7k8r) | Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C135 | 分子名称: | C135 Fab Heavy Chain, C135 Fab Light Chain, GLYCEROL | 著者 | Jette, C.A, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8Z
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![BU of 7k8z by Molmil](/molmil-images/mine/7k8z) | |
7K8M
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![BU of 7k8m by Molmil](/molmil-images/mine/7k8m) | Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C102 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C102 Fab Heavy Chain, C102 Fab Light Chain, ... | 著者 | Jette, C.A, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8V
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![BU of 7k8v by Molmil](/molmil-images/mine/7k8v) | Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C110 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C110 Fab Heavy Chain, ... | 著者 | Dam, K.A, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8O
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![BU of 7k8o by Molmil](/molmil-images/mine/7k8o) | Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C002 | 分子名称: | C002 Fab Heavy Chain, C002 Fab Light Chain, GLYCEROL, ... | 著者 | Jette, C.A, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K8W
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![BU of 7k8w by Molmil](/molmil-images/mine/7k8w) | Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C119 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C119 Fab Heavy Chain, ... | 著者 | Sharaf, N.G, Barnes, C.O, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7A29
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7K8U
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![BU of 7k8u by Molmil](/molmil-images/mine/7k8u) | Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C104 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C104 Fab Heavy Chain, ... | 著者 | Barnes, C.O, Malyutin, A.G, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7K90
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![BU of 7k90 by Molmil](/molmil-images/mine/7k90) | Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C144 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C144 Fab Heavy Chain, C144 Fab Light Chain, ... | 著者 | Barnes, C.O, Esswein, S.R, Bjorkman, P.J. | 登録日 | 2020-09-27 | 公開日 | 2020-10-21 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature, 588, 2020
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7JJC
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7ACT
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![BU of 7act by Molmil](/molmil-images/mine/7act) | |
7AKU
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![BU of 7aku by Molmil](/molmil-images/mine/7aku) | Structure of SARS-CoV-2 Main Protease bound to Calpeptin. | 分子名称: | 3C-like proteinase, CHLORIDE ION, Calpeptin | 著者 | Guenther, S, Reinke, P, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Paulraj, L.X, Ullah, N, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Doyle, J.J, Giseler, H, Melo, D, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | 登録日 | 2020-10-02 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372, 2021
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7K9Z
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![BU of 7k9z by Molmil](/molmil-images/mine/7k9z) | Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 298 Fab Heavy Chain, 298 Fab Light Chain, ... | 著者 | Newton, J.C, Kucharska, I, Rujas, E, Cui, H, Julien, J.P. | 登録日 | 2020-09-29 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nat Commun, 12, 2021
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7D1M
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![BU of 7d1m by Molmil](/molmil-images/mine/7d1m) | CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, DIMETHYL SULFOXIDE | 著者 | Fu, L.F, Gilski, M, Shabalin, I, Gao, G.F, Qi, J.X. | 登録日 | 2020-09-14 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020
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7KFI
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![BU of 7kfi by Molmil](/molmil-images/mine/7kfi) | SARS-CoV-2 Main protease immature form - apo structure | 分子名称: | 3C-like proteinase, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE | 著者 | Noske, G.D, Nakamura, A.M, Gawriljuk, V.O, Lima, G.M.A, Zeri, A.C.M, Nascimento, A.F.Z, Oliva, G, Godoy, A.S. | 登録日 | 2020-10-14 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process. J.Mol.Biol., 433, 2021
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7KG3
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![BU of 7kg3 by Molmil](/molmil-images/mine/7kg3) | Crystal structure of CoV-2 Nsp3 Macrodomain | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ... | 著者 | Arvai, A, Brosey, C.A, Link, T, Jones, D.E, Ahmed, Z, Tainer, J.A. | 登録日 | 2020-10-15 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog.Biophys.Mol.Biol., 163, 2021
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7KHP
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![BU of 7khp by Molmil](/molmil-images/mine/7khp) | Acyl-enzyme intermediate structure of SARS-CoV-2 Mpro in complex with its C-terminal autoprocessing sequence. | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE | 著者 | Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J. | 登録日 | 2020-10-21 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nat Commun, 11, 2020
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7ACS
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![BU of 7acs by Molmil](/molmil-images/mine/7acs) | |
7KDL
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![BU of 7kdl by Molmil](/molmil-images/mine/7kdl) | |