PDB: 480 件ウェブページステータス検索Chemie searchBIRD

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7MYO	Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719 分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. 登録日 2021-05-21 公開日 2021-11-10 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118, 2021
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-23 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
6ZWO	cryo-EM structure of human mTOR complex 2, focused on one half 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
6ZWM	cryo-EM structure of human mTOR complex 2, overall refinement 分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. 登録日 2020-07-28 公開日 2020-11-18 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
4D0L	Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... 著者 Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. 登録日 2014-04-29 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science, 344, 2014
4D0M	Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... 著者 Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughlin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. 登録日 2014-04-29 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science, 344, 2014
4JSN	structure of mTORdeltaN-mLST8 complex 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT6	structure of mTORDeltaN-mLST8-PI-103 complex 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSV	mTOR kinase structure, mechanism and regulation. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JPS	Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors 分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Knapp, M.S, Elling, R.A. 登録日 2013-03-19 公開日 2014-04-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg.Med.Chem.Lett., 23, 2013
4JSP	structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT5	mTORdeltaN-mLST8-pp242 complex 分子名称: 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSX	structure of mTORDeltaN-mLST8-Torin2 complex 分子名称: 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4L23	Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-04 公開日 2014-01-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
4L2Y	Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d 分子名称: 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-05 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
4L1B	Crystal Structure of p110alpha complexed with niSH2 of p85alpha 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, SULFATE ION 著者 Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. 登録日 2013-06-03 公開日 2014-01-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.586 Å) 主引用文献 Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
5DFZ	Structure of Vps34 complex II from S. cerevisiae. 分子名称: Nanobody binding S. cerevisiae Vps34, Phosphatidylinositol 3-kinase VPS34, Putative N-terminal domain of S. cerevisiae Vps30, ... 著者 Rostislavleva, K, Soler, N, Ohashi, Y, Zhang, L, Williams, R.L. 登録日 2015-08-27 公開日 2015-10-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science, 350, 2015
5EUQ	Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11 分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Burke, J.E, Fowler, M.L. 登録日 2015-11-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase III beta. J.Med.Chem., 59, 2016
5FBW	PI4KB in complex with Rab11 and the MI369 Inhibitor 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. 登録日 2015-12-14 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.487 Å) 主引用文献 PI4KB in complex with Rab11 and the MI369 Inhibitor To Be Published
5FI4	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... 著者 Elling, R.A, Knapp, M.S, Han, W, Daniel, L.M, Xy, Y, Burger, M.T, Ni, Z, Smith, A, Lan, J, Williams, T, Verhagen, J, Huh, K, Merritt, H, Chan, J, Kaufman, S, Voliva, C.F, Pecchi, S. 登録日 2015-12-22 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg.Med.Chem.Lett., 26, 2016
5FBQ	PI4KB in complex with Rab11 and the MI358 Inhibitor 分子名称: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. 登録日 2015-12-14 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.789 Å) 主引用文献 PI4KB in complex with Rab11 and the MI358 Inhibitor To Be Published
5FBL	PI4KB in complex with Rab11 and the MI356 Inhibitor 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. 登録日 2015-12-14 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.372 Å) 主引用文献 PI4KB in complex with Rab11 and the MI356 Inhibitor To Be Published
5FBV	PI4KB in complex with Rab11 and the MI364 Inhibitor 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. 登録日 2015-12-14 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.285 Å) 主引用文献 PI4KB in complex with Rab11 and the MI364 Inhibitor To Be Published
5FLC	Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction 分子名称: FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... 著者 Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. 登録日 2015-10-23 公開日 2015-12-30 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Architecture of Human Mtor Complex 1 Science, 351, 2016
5FBR	PI4KB in complex with Rab11 and the MI359 Inhibitor 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... 著者 Chalupska, D, Mejdrova, I, Nencka, R, Boura, E. 登録日 2015-12-14 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 PI4KB in complex with Rab11 and the MI359 Inhibitor To Be Published

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