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4Y46
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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-10
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-11
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.055 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
5LW1
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BU of 5lw1 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide
分子名称: ADENOSINE, C-Jun-amino-terminal kinase-interacting protein 1, DD_232_11_D12, ...
著者Wu, Y, Batyuk, A, Mittl, P.R, Honegger, A, Plueckthun, A.
登録日2016-09-15
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.
J.Mol.Biol., 430, 2018
5VPD
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BU of 5vpd by Molmil
Transcription factor FosB/JunD bZIP domain in its oxidized form, type-III crystal
分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ...
著者Yin, Z, Machius, M, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPE
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Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-I crystal
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ...
著者Yin, Z, Machius, M, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.053 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPC
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Transcription factor FosB/JunD bZIP domain in its oxidized form, type-II crystal
分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ...
著者Yin, Z, Machius, M.C, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.498 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPB
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Transcription factor FosB/JunD bZIP domain in its oxidized form, type-I crystal
分子名称: CHLORIDE ION, Protein fosB, Transcription factor jun-D
著者Yin, Z, Machius, M, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.691 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPA
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Transcription factor FosB/JunD bZIP domain
分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ...
著者Yin, Z, Machius, M, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPF
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Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-II crystal
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ...
著者Yin, Z, Rudenko, G, Machius, M.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VKT
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BU of 5vkt by Molmil
Cinnamyl alcohol dehydrogenases (SbCAD4) from Sorghum bicolor (L.) Moench
分子名称: ACETATE ION, Cinnamyl alcohol dehydrogenases (SbCAD4), D-MALATE, ...
著者Walker, A.M, Jun, S.Y, Kang, C.
登録日2017-04-22
公開日2017-08-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.827 Å)
主引用文献The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum (Sorghum bicolor), SbCAD2 and SbCAD4.
Plant Physiol., 174, 2017
7UCC
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BU of 7ucc by Molmil
Transcription factor FosB/JunD bZIP domain in the reduced form
分子名称: CHLORIDE ION, ETHANOL, Protein fosB, ...
著者Kumar, A, Machius, M.C, Rudenko, G.
登録日2022-03-16
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Chemically targeting the redox switch in AP1 transcription factor Delta FOSB.
Nucleic Acids Res., 50, 2022
7UCD
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BU of 7ucd by Molmil
Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480
分子名称: 7-acetyl-4-methoxy-1-benzofuran-3(2H)-one, CHLORIDE ION, Protein fosB, ...
著者Kumar, A, Machius, M.C, Rudenko, G.
登録日2022-03-16
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Chemically targeting the redox switch in AP1 transcription factor Delta FOSB.
Nucleic Acids Res., 50, 2022
2G01
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BU of 2g01 by Molmil
Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
分子名称: 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE, C-jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, ...
著者Abad-Zapatero, C.
登録日2006-02-10
公開日2006-04-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
1JNM
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Crystal Structure of the Jun/CRE Complex
分子名称: 5'-D(*CP*GP*TP*CP*GP*AP*TP*GP*AP*CP*GP*TP*CP*AP*TP*CP*GP*AP*CP*G)-3', PROTO-ONCOGENE C-JUN
著者Kim, Y, Podust, L.M.
登録日2001-07-24
公開日2003-06-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the Jun bZIP homodimer complexed with CRE
To be Published
5EN2
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BU of 5en2 by Molmil
Molecular basis for antibody-mediated neutralization of New World hemorrhagic fever mammarenaviruses
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Mahmutovic, S, Clark, L, Levis, S, Briggiler, A, Enria, D, Harrison, S.C, Abraham, J.
登録日2015-11-09
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.821 Å)
主引用文献Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses.
Cell Host Microbe, 18, 2015
6XJF
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BU of 6xjf by Molmil
X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha (SeMet labeled protein)
分子名称: Transcription factor E
著者Murakami, K.S, Jun, S.H.
登録日2020-06-23
公開日2020-07-08
最終更新日2021-01-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Nat Commun, 11, 2020
3VUD
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BU of 3vud by Molmil
Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1
分子名称: Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-06-28
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUM
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BU of 3vum by Molmil
Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ...
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-07-02
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUH
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BU of 3vuh by Molmil
Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1
分子名称: GLYCEROL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ...
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-06-28
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUL
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BU of 3vul by Molmil
Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1
分子名称: Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-07-02
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUK
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BU of 3vuk by Molmil
Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1
分子名称: Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-07-02
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUG
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BU of 3vug by Molmil
Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1
分子名称: Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-06-28
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
3VUI
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BU of 3vui by Molmil
Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1
分子名称: Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION
著者Nakaniwa, T, Kinoshita, T, Inoue, T.
登録日2012-06-28
公開日2013-02-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Biochemistry, 51, 2012
4GKL
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BU of 4gkl by Molmil
Crystal structure of a noncanonic maltogenic alpha-amylase AmyB from Thermotoga neapolitana
分子名称: Alpha-amylase
著者Ha, N.C, Jun, S.Y, Kim, J.S.
登録日2012-08-13
公開日2013-02-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of a novel alpha-amylase AmyB from Thermotoga neapolitana that produces maltose from the nonreducing end of polysaccharides
Acta Crystallogr.,Sect.D, 69, 2013
3OOB
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Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate
分子名称: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
著者Urusova, D.V, Shim, J.-H, Kim, D.-J, Jung, S.K, Zykova, T.A, Bode, A.M, Dong, Z.
登録日2010-08-30
公開日2011-08-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
Cancer Prev Res (Phila), 4, 2011

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