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6T46
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BU of 6t46 by Molmil
Structure of the Rap conjugation gene regulator of the plasmid pLS20 in complex with the Phr* peptide
分子名称: CHLORIDE ION, Quorum-sensing secretion protein (processed), Response regulator aspartate phosphatase, ...
著者Crespo, I, Bernardo, N, Meijer, W.J.J, Boer, D.R.
登録日2019-10-12
公開日2020-06-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization.
Nucleic Acids Res., 48, 2020
2WF4
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BU of 2wf4 by Molmil
Human BACE-1 in complex with 6-ethyl-1-methyl-N-((1S)-2-oxo-1-(phenylmethyl)-3-(tetrahydro-2H-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide
分子名称: BETA-SECRETASE 1, N-[(1S)-1-BENZYL-2,2-DIHYDROXY-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL]-6-ETHYL-1-METHYL-1,3,4,6-TETRAHYDRO[1,2]THIAZEPINO[5,4,3-CD]INDOLE-8-CARBOXAMIDE 2,2-DIOXIDE
著者Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, Hawkins, J, Howes, C, Hubbard, J, Hussain, I, Maile, G, Matico, R, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G.
登録日2009-04-02
公開日2009-05-12
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Second Generation of Bace-1 Inhibitors Part 3: Towards Non Hydroxyethylamine Transition State Mimetics.
Bioorg.Med.Chem.Lett., 19, 2009
6RFP
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BU of 6rfp by Molmil
ERK2 MAP kinase with mutations at Helix-G
分子名称: Mitogen-activated protein kinase 1
著者Livnah, O, Eitan-Wexler, M.
登録日2019-04-16
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop.
J.Biol.Chem., 295, 2020
6TXF
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BU of 6txf by Molmil
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mn
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ...
著者Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
登録日2020-01-14
公開日2020-06-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
6T3H
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BU of 6t3h by Molmil
Structure of the Rap conjugation gene regulator of the plasmid pLS20 in apo form
分子名称: Response regulator aspartate phosphatase
著者Crespo, I, Bernardo, N, Meijer, W.J.J, Boer, D.R.
登録日2019-10-11
公開日2020-06-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.039 Å)
主引用文献Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization.
Nucleic Acids Res., 48, 2020
2WND
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BU of 2wnd by Molmil
Structure of an S100A7 triple mutant
分子名称: CALCIUM ION, PROTEIN S100-A7, ZINC ION
著者West, N.R, Farnell, B, Watson, P.H, Boulanger, M.J.
登録日2009-07-08
公開日2009-11-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and Functional Characterization of a Triple Mutant Form of S100A7 Defective for Jab1 Binding.
Protein Sci., 18, 2009
6UCM
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BU of 6ucm by Molmil
Transcription factor DeltaFosB bZIP domain self-assembly, type-II crystal
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Protein fosB
著者Yin, Z, Machius, M, Rudenko, G.
登録日2019-09-16
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.424 Å)
主引用文献Self-assembly of the bZIP transcription factor Delta FosB.
Curr Res Struct Biol, 2, 2020
4L7F
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BU of 4l7f by Molmil
Co-crystal Structure of JNK1 and AX13587
分子名称: Mitogen-activated protein kinase 8, N-[1-(4-fluorophenyl)cyclopropyl]-4-[(trans-4-hydroxycyclohexyl)amino]imidazo[1,2-a]quinoxaline-8-carboxamide
著者Walter, R.L, Ranieri, G.M, Riggs, A.M, Weissig, H, Li, B, Shreder, K.R.
登録日2013-06-13
公開日2013-08-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4KKG
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BU of 4kkg by Molmil
Crystal structure of apo and AMP-bound JNK3
分子名称: Mitogen-activated protein kinase 10
著者Han, B.G, Shim, M.B, Ahn, H.C.
登録日2013-05-06
公開日2014-05-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献crystal structure of apo and AMP-bound JNK3
To be Published
4KKH
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BU of 4kkh by Molmil
The crystal structure of inhibitor-bound JNK3
分子名称: Mitogen-activated protein kinase 10, cyclopropyl[(3R)-3-({4-[6-hydroxy-2-(naphthalen-2-yl)-1H-benzimidazol-1-yl]pyrimidin-2-yl}amino)piperidin-1-yl]methanone
著者Han, B.G, Shim, M.B, Ahn, H.C.
登録日2013-05-06
公開日2014-05-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of AMP, apo, and inhibitor-bound JNK3
To be Published
4KKE
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BU of 4kke by Molmil
The crystal structure of AMP-bound JNK3
分子名称: ADENOSINE MONOPHOSPHATE, Mitogen-activated protein kinase 10
著者Han, B.G, Shim, M.B, Ahn, H.C.
登録日2013-05-06
公開日2014-05-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The crystal structure of AMP-bound JNK3
To be Published
8Y0X
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BU of 8y0x by Molmil
Dormant ribosome with SERBP1
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Du, M, Zeng, F.
登録日2024-01-23
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The global structure of dormant ribosome
To Be Published
8WMN
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BU of 8wmn by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (symmetric 20-nt complementary)
分子名称: DNA (62-MER), MAGNESIUM ION, PcrIIC1, ...
著者Zhang, S, Lin, S, Liu, J.J.G.
登録日2023-10-04
公開日2024-06-05
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
8Y0W
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BU of 8y0w by Molmil
dormant ribosome with eIF5A, eEF2 and SERBP1
分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
著者Du, M, Zeng, F.
登録日2024-01-23
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献dormant ribosome with eIF5A, eEF2 and SERBP1
To Be Published
8WMM
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BU of 8wmm by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary)
分子名称: MAGNESIUM ION, NTS, PcrIIC1, ...
著者Zhang, S, Lin, S, Liu, J.J.G.
登録日2023-10-04
公開日2024-06-05
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
5JOG
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BU of 5jog by Molmil
CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3
分子名称: 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide, COP9 signalosome complex subunit 5, ZINC ION
著者Renatus, M, Wiesmann, C.
登録日2016-05-02
公開日2016-11-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nat Commun, 7, 2016
8WMH
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BU of 8wmh by Molmil
Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate
分子名称: NTS, TS, deadCbCas9, ...
著者Zhang, S, Lin, S, Liu, J.J.G.
登録日2023-10-03
公開日2024-06-05
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
8WR4
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BU of 8wr4 by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (non-targeting complex)
分子名称: CbCas9 effector-1, DNA (62-MER), MAGNESIUM ION, ...
著者Zhang, S, Lin, S, Liu, J.J.G.
登録日2023-10-13
公開日2024-06-05
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
6DD5
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BU of 6dd5 by Molmil
Crystal Structure of the Cas6 Domain of Marinomonas mediterranea MMB-1 Cas6-RT-Cas1 Fusion Protein
分子名称: GLYCEROL, MMB-1 Cas6 Fused to Maltose Binding Protein,CRISPR-associated endonuclease Cas1, SULFATE ION, ...
著者Stamos, J.L, Mohr, G, Silas, S, Makarova, K.S, Markham, L.M, Yao, J, Lucas-Elio, P, Sanchez-Amat, A, Fire, A.Z, Koonin, E.V, Lambowitz, A.M.
登録日2018-05-09
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition.
Mol. Cell, 72, 2018
6DKQ
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BU of 6dkq by Molmil
Crystal structure of the Shr Hemoglobin Interacting Domain 2
分子名称: Heme-binding protein Shr, SULFATE ION
著者Macdonald, R, Cascio, D, Collazo, M.J, Clubb, R.T.
登録日2018-05-30
公開日2018-10-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains.
J.Biol.Chem., 293, 2018
6EKC
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BU of 6ekc by Molmil
Crystal structure of the BSD2 homolog of Arabidopsis thaliana bound to the octameric assembly of RbcL from Thermosynechococcus elongatus
分子名称: DnaJ/Hsp40 cysteine-rich domain superfamily protein, Ribulose bisphosphate carboxylase large chain, ZINC ION
著者Aigner, H, Wilson, R.H, Bracher, A, Calisse, L, Bhat, J.Y, Hartl, F.U, Hayer-Hartl, M.
登録日2017-09-26
公開日2017-12-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Plant RuBisCo assembly in E. coli with five chloroplast chaperones including BSD2.
Science, 358, 2017
4URI
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BU of 4uri by Molmil
Crystal structure of chitinase-like agglutinin RobpsCRA from Robinia pseudoacacia
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHITINASE-RELATED AGGLUTININ, CHLORIDE ION, ...
著者Sulzenbacher, G, Roig-Zamboni, V, Peumans, W.J, Henrissat, B, van Damme, E.J.M, Bourne, Y.
登録日2014-06-30
公開日2015-03-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Basis for Carbohydrate Binding Properties of a Plant Chitinase-Like Agglutinin with Conserved Catalytic Machinery.
J.Struct.Biol., 190, 2015
3KZU
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BU of 3kzu by Molmil
Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Brucella melitensis
分子名称: 1,2-ETHANEDIOL, 3-oxoacyl-(Acyl-carrier-protein) synthase ii, SULFATE ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-12-08
公開日2009-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Brucella melitensis
TO BE PUBLISHED
6E2M
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BU of 6e2m by Molmil
ASK1 kinase domain complex with inhibitor
分子名称: Mitogen-activated protein kinase kinase kinase 5, N-[3-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide
著者Lansdon, E.B.
登録日2018-07-11
公開日2018-09-19
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.253 Å)
主引用文献ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J. Clin. Invest., 128, 2018
6E2N
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BU of 6e2n by Molmil
ASK1 kinase domain complex with inhibitor
分子名称: Mitogen-activated protein kinase kinase kinase 5, N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl][3,4'-bipyridine]-2'-carboxamide
著者Lansdon, E.B.
登録日2018-07-11
公開日2018-09-19
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J. Clin. Invest., 128, 2018

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