6PXR
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![BU of 6pxr by Molmil](/molmil-images/mine/6pxr) | Anti-TAU BIIB092 FAB with TAU peptide | 分子名称: | Microtubule-associated protein tau, gosuranemab Fab, heavy chain, ... | 著者 | Arndt, J.W, Quan, C. | 登録日 | 2019-07-26 | 公開日 | 2020-07-29 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (1.556 Å) | 主引用文献 | Characterization of tau binding by gosuranemab. Neurobiol.Dis., 146, 2020
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6QTJ
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![BU of 6qtj by Molmil](/molmil-images/mine/6qtj) | Crystal structure of human CDK8/CYCC in complex with BI 919811 | 分子名称: | Cyclin-C, Cyclin-dependent kinase 8, ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide | 著者 | Boettcher, J. | 登録日 | 2019-02-25 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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6QTG
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![BU of 6qtg by Molmil](/molmil-images/mine/6qtg) | Crystal structure of human CDK8/CYCC in complex with BI-1347 | 分子名称: | 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, Cyclin-C, Cyclin-dependent kinase 8 | 著者 | Boettcher, J. | 登録日 | 2019-02-25 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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3PR0
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![BU of 3pr0 by Molmil](/molmil-images/mine/3pr0) | Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptane-1,1-diol, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mileni, M, Han, G.W, Boger, D.L, Stevens, R.C. | 登録日 | 2010-11-29 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133, 2011
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3PPM
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![BU of 3ppm by Molmil](/molmil-images/mine/3ppm) | Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | 1-DODECANOL, 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptan-1-one, CHLORIDE ION, ... | 著者 | Mileni, M, Han, G.W, Boger, D.L, Stevens, R.C. | 登録日 | 2010-11-24 | 公開日 | 2011-11-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133, 2011
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6RBW
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![BU of 6rbw by Molmil](/molmil-images/mine/6rbw) | |
6RC6
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![BU of 6rc6 by Molmil](/molmil-images/mine/6rc6) | |
6O4D
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![BU of 6o4d by Molmil](/molmil-images/mine/6o4d) | Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde dehydrogenase, DI(HYDROXYETHYL)ETHER, ... | 著者 | Tanner, J.J, Korasick, D.A, Laciak, A.R. | 登録日 | 2019-02-28 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1. Febs J., 287, 2020
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6RBS
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6RBZ
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![BU of 6rbz by Molmil](/molmil-images/mine/6rbz) | |
6RBP
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![BU of 6rbp by Molmil](/molmil-images/mine/6rbp) | |
6O4B
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![BU of 6o4b by Molmil](/molmil-images/mine/6o4b) | Structure of ALDH7A1 mutant W175G complexed with NAD | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde dehydrogenase, CHLORIDE ION, ... | 著者 | Tanner, J.J, Korasick, D.A, Laciak, A.R. | 登録日 | 2019-02-28 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1. Febs J., 287, 2020
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6RBY
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![BU of 6rby by Molmil](/molmil-images/mine/6rby) | |
6R4T
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![BU of 6r4t by Molmil](/molmil-images/mine/6r4t) | |
6R4J
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![BU of 6r4j by Molmil](/molmil-images/mine/6r4j) | Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ... | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | 登録日 | 2019-03-22 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R5E
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![BU of 6r5e by Molmil](/molmil-images/mine/6r5e) | |
6RB4
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![BU of 6rb4 by Molmil](/molmil-images/mine/6rb4) | |
6RBO
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![BU of 6rbo by Molmil](/molmil-images/mine/6rbo) | |
6RBV
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![BU of 6rbv by Molmil](/molmil-images/mine/6rbv) | |
6RC5
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![BU of 6rc5 by Molmil](/molmil-images/mine/6rc5) | |
6R4E
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![BU of 6r4e by Molmil](/molmil-images/mine/6r4e) | Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | 登録日 | 2019-03-22 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6R4I
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![BU of 6r4i by Molmil](/molmil-images/mine/6r4i) | Crystal structure of human GFAT-1 G461E | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | 登録日 | 2019-03-22 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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6RBR
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![BU of 6rbr by Molmil](/molmil-images/mine/6rbr) | |
6RC2
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![BU of 6rc2 by Molmil](/molmil-images/mine/6rc2) | |
6R4H
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![BU of 6r4h by Molmil](/molmil-images/mine/6r4h) | Crystal structure of human GFAT-1 G451E | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | 登録日 | 2019-03-22 | 公開日 | 2020-01-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11, 2020
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