PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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4YAQ	Crystal structure of a computationally optimized PG9 mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PG9_N100FY Fab heavy chain, ... 著者 Murrell, S, Julien, J.P, Wilson, I.A. 登録日 2015-02-17 公開日 2015-06-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. J.Clin.Invest., 125, 2015
4M7L	Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment 分子名称: 10H10 heavy chain, 10H10 light chain, Tissue factor 著者 Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. 登録日 2013-08-12 公開日 2014-08-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment To be Published
7KBT	Factor VIII in complex with the anti-C2 domain antibody, G99 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Ronayne, E.K, Gish, J, Wilson, C, Peters, S, Spencer, H.T, Spiegel, P.C, Childers, K.C. 登録日 2020-10-02 公開日 2020-11-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4.15 Å) 主引用文献 Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor Front Immunol, 12, 2021
6PCU	VP8* of a G2P[4] human rotavirus in complex with scFv antibody 9 分子名称: GLYCEROL, Outer capsid protein VP4, SULFATE ION, ... 著者 Hu, L, Venkataram Prasad, B.V. 登録日 2019-06-18 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells. J.Clin.Invest., 130, 2019
7AEJ	Crystal structure of asymmetric HIV-1 gp41 containing all membrane anchors 分子名称: 2H10, Envelope glycoprotein gp160,Envelope glycoprotein gp160 著者 Caillat, C, Guilligay, D, Weissenhorn, W. 登録日 2020-09-17 公開日 2021-05-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies. Elife, 10, 2021
8F92	HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B11_d77.7 Fab heavy chain, ... 著者 Torres, J.L, Ozorowski, G, Ward, A.B. 登録日 2022-11-23 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. Science, 384, 2024
8F9M	HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505_MD64_N332-GT5 gp120, ... 著者 Ozorowski, G, Ward, A.B. 登録日 2022-11-23 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. Science, 384, 2024
8F9G	HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized BG18HCgl knock-in mice 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505_MD64_N332-GT5 gp120, ... 著者 Ozorowski, G, Torres, J.L, Ward, A.B. 登録日 2022-11-23 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. Science, 384, 2024
6FGO	Fc in complex with engineered calcium binding domain Z 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Venskutonyte, R, Kanje, S, Hober, S, Lindkvist-Petersson, K. 登録日 2018-01-11 公開日 2018-06-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies. J. Mol. Biol., 430, 2018
4M6N	Crystal structure of anti-IL-23 antibody CNTO1959 at pH 6.5 分子名称: CNTO1959 heavy chain, CNTO1959 light chain, FORMIC ACID 著者 Teplyakov, A, Obmolova, G, Gilliland, G.L. 登録日 2013-08-09 公開日 2014-08-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 crystal structure of anti-IL-23 antibody CNTO1959 at pH 6.5 To be Published
7L3N	SARS-CoV 2 Spike Protein bound to LY-CoV555 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV555 Fab heavy chain, ... 著者 Goldsmith, J.A, McLellan, J.S. 登録日 2020-12-18 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. Biorxiv, 2020
4K3H	Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green 分子名称: 4-{bis[4-(dimethylamino)phenyl]methyl}phenol, GLYCEROL, Immunoglobulin lambda variable domain L5(L89S), ... 著者 Stanfield, R.L, Szent-Gyorgyi, C, Wilson, I.A. 登録日 2013-04-10 公開日 2013-10-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Malachite Green Mediates Homodimerization of Antibody VL Domains to Form a Fluorescent Ternary Complex with Singular Symmetric Interfaces. J.Mol.Biol., 425, 2013
7FAE	S protein of SARS-CoV-2 in complex bound with P36-5D2(state2) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P36-5D2 heavy chain, ... 著者 Zhang, L, Wang, X, Shan, S, Zhang, S. 登録日 2021-07-06 公開日 2021-12-22 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants. Front Immunol, 12, 2021
8IV5	Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 1C4 (local refinement) 分子名称: Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, heavy chain of 1C4, ... 著者 Sun, H, Jiang, Y, Zheng, Q, Li, S, Xia, N. 登録日 2023-03-26 公開日 2023-08-16 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.77 Å) 主引用文献 Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15, 2024
8IV8	Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 3E2 and 1C4 (local refinement) 分子名称: Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, heavy chain of 1C4, ... 著者 Sun, H, Jiang, Y, Zheng, Q, Li, S, Xia, N. 登録日 2023-03-26 公開日 2023-08-16 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15, 2024
8IVA	Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs XMA01 and 3E2 (local refinement) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, heavy chain of 3E2, ... 著者 Sun, H, Jiang, Y, Zheng, Q, Li, S, Xia, N. 登録日 2023-03-26 公開日 2023-08-16 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.95 Å) 主引用文献 Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15, 2024
8IV4	Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, heavy chain of 3E2, ... 著者 Sun, H, Jiang, Y, Zheng, Q, Li, S, Xia, N. 登録日 2023-03-26 公開日 2023-08-16 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15, 2024
8TCA	Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification, no ligand 分子名称: 1,2-ETHANEDIOL, m6A binding IgG Fab, heavy chain, ... 著者 Angelo, M.C, Aoki, S.T. 登録日 2023-06-30 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structure of a mouse IgG antibody antigen-binding fragment (Fab) targeting N6-methyladenosine (m6A), an RNA modification To Be Published
4NNP	Crystal Structure of Apo Manganese ABC transporter MntC from Staphylococcus aureus bound to an antagonistic fab fragment 分子名称: Heavy chain of antagonistic fab fragment, Light chain of antagonistic fab fragment, Lipoprotein 著者 Rouge, L, Sudhamsu, J. 登録日 2013-11-18 公開日 2014-12-10 最終更新日 2020-05-20 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural analysis of bacterial ABC transporter inhibition by an antibody fragment. Structure, 23, 2015
8D0Y	Crystal Structure of HIV-1 BG505 SOSIPv8 Trimer in Complex with CD4bs targeting antibody 21N13 and interface targeting antibody 35O22 at 4.7 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22scFv Heavy Chain Variable, ... 著者 Xian, Y, Wilson, I.A. 登録日 2022-05-26 公開日 2023-07-19 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (4.7 Å) 主引用文献 The domain-swaped dimer of the HIV-1 CD4bs targeting antibody 21N13 To Be Published
7CYH	Binding interface of SARS-CoV-2 RBD and its neutralizing antibody HB27 分子名称: Heavy chain of HB27, Light chain of HB27, Spike glycoprotein 著者 Wang, X, Zhu, L. 登録日 2020-09-03 公開日 2021-06-09 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Binding interface of SARS-CoV-2 RBD and its neutralizing antibody HB27 To Be Published
8SVE	Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Fab Heavy chain, ... 著者 DiDonato, M, Spraggon, G. 登録日 2023-05-16 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Novel Interleukin-10 Antibody Graft to Treat Inflammatory Bowel Disease. To Be Published
7DOH	Crystal Structure of GD-26 Fab in Complex with TD Peptide from Haloarcula Marismortui Bacteriorhodopsin I 分子名称: GD-26 Fab H-chain, GD-26 Fab L-chain, GLY-THR-GLY-ALA-THR-PRO-ALA-ASP-ASP 著者 Lee, C.C, Pao, P.J, Wang, A.H.J. 登録日 2020-12-14 公開日 2021-10-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural basis of an epitope tagging system derived from Haloarcula marismortui bacteriorhodopsin I D94N and its monoclonal antibody GD-26. Febs J., 289, 2022
6GKT	X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu 分子名称: Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... 著者 Verstraete, K, Verschueren, K, Savvides, S.N. 登録日 2018-05-21 公開日 2019-06-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science, 364, 2019
6AXL	Crystal structure of Fab317 complex 分子名称: Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2 著者 Oyen, D, Wilson, I.A. 登録日 2017-09-07 公開日 2017-11-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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