4YAQ

Crystal structure of a computationally optimized PG9 mutant

Summary for 4YAQ

• Entry DOI: 10.2210/pdb4yaq/pdb
• Descriptor: PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: antibody, hiv, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 102242.92

Authors

Murrell, S.,Julien, J.P.,Wilson, I.A. (deposition date: 2015-02-17, release date: 2015-06-03, Last modification date: 2023-11-15)

• Primary citation: Willis, J.R.,Sapparapu, G.,Murrell, S.,Julien, J.P.,Singh, V.,King, H.G.,Xia, Y.,Pickens, J.A.,LaBranche, C.C.,Slaughter, J.C.,Montefiori, D.C.,Wilson, I.A.,Meiler, J.,Crowe, J.E.; Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.; J.Clin.Invest., 125:2523-2531, 2015; PubMed: 25985274; DOI: 10.1172/JCI80693

Experimental method

X-RAY DIFFRACTION (2.3 Å)