4YAQ

Crystal structure of a computationally optimized PG9 mutant

Summary for 4YAQ

DescriptorPG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
Functional Keywordsantibody, hiv, immune system
Biological sourceHomo sapiens
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Total number of polymer chains4
Total molecular weight102314.98
Authors
Murrell, S.,Julien, J.P.,Wilson, I.A. (deposition date: 2015-02-17, release date: 2015-06-03, Last modification date: 2017-08-23)
Primary citation
Willis, J.R.,Sapparapu, G.,Murrell, S.,Julien, J.P.,Singh, V.,King, H.G.,Xia, Y.,Pickens, J.A.,LaBranche, C.C.,Slaughter, J.C.,Montefiori, D.C.,Wilson, I.A.,Meiler, J.,Crowe, J.E.
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
J.Clin.Invest., 125:2523-2531, 2015
PubMed: 25985274 (PDB entries with the same primary citation)
DOI: 10.1172/JCI80693
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.242500.4%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report