4ITD
| Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation | 分子名称: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*GP*(C6G)P*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | 著者 | Zhang, F, Suzuki, K, Tsunoda, M, Wilkinson, O, Millington, C.L, Williams, D.M, Morishita, E.C, Takenaka, A. | 登録日 | 2013-01-18 | 公開日 | 2013-05-08 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations Nucleic Acids Res., 41, 2013
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4JUY
| Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31 | 分子名称: | E3 ubiquitin-protein ligase RNF31, UNKNOWN ATOM OR ION | 著者 | Dong, A, Hu, J, Li, Y, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2013-03-25 | 公開日 | 2013-04-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31 To be Published
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4JUO
| A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32 | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, ... | 著者 | Laponogov, I, Veselkov, D.A, Pan, X.-S, Crevel, I, Fisher, L.M, Sanderson, M.R. | 登録日 | 2013-03-25 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (6.53 Å) | 主引用文献 | Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport. Nucleic Acids Res., 41, 2013
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4J7T
| Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | 分子名称: | D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-02-14 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.203 Å) | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
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4JC3
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4JHC
| Crystal structure of the uncharacterized Maf protein YceF from E. coli | 分子名称: | GLYCEROL, Maf-like protein YceF, UNKNOWN ATOM OR ION | 著者 | Dong, A, Xu, X, Cui, H, Tchigvintsev, A, Flick, R, Brown, G, Popovic, A, Yakunin, A.F, Savchenko, A. | 登録日 | 2013-03-04 | 公開日 | 2013-03-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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4JAZ
| Crystal structure of the complex between PPARgamma LBD and trans-resveratrol | 分子名称: | Peroxisome proliferator-activated receptor gamma, RESVERATROL | 著者 | Pochetti, G, Capelli, D, Montanari, R, Calleri, E, Moaddel, R, Temporini, C. | 登録日 | 2013-02-19 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Resveratrol and Its Metabolites Bind to PPARs. Chembiochem, 15, 2014
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4JPC
| Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors | 分子名称: | 3-[(4R)-2'-amino-1',2,2-trimethyl-5'-oxo-1',2,3,5'-tetrahydrospiro[chromene-4,4'-imidazol]-6-yl]benzonitrile, Beta-secretase 1, NICKEL (II) ION | 著者 | Vigers, G.P.A, Smith, D. | 登録日 | 2013-03-19 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species. J.Med.Chem., 56, 2013
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4J71
| Crystal Structure of GSK3b in complex with inhibitor 1R | 分子名称: | (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, CHLORIDE ION, Glycogen synthase kinase-3 beta, ... | 著者 | Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-02-12 | 公開日 | 2013-03-20 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
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4JQ0
| Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin | 分子名称: | CALCIUM ION, Calmodulin, Fibroblast growth factor 12, ... | 著者 | Wang, C, Chung, B.C, Yan, H, Wang, H.G, Lee, S.Y, Pitt, G.S. | 登録日 | 2013-03-19 | 公開日 | 2014-05-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.84 Å) | 主引用文献 | Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. Nat Commun, 5, 2014
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4JT3
| Crystal Structure of TTK kinase domain with an inhibitor: 400740 | 分子名称: | 1,2-ETHANEDIOL, 2-phenyl-N-[3-(3-sulfamoylphenyl)-2H-indazol-5-yl]acetamide, Dual specificity protein kinase TTK, ... | 著者 | Qiu, W, Harris-Brandts, M, Feher, M, Awrey, D.E, Chirgadze, N.Y. | 登録日 | 2013-03-22 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of TTK kinase domain with an inhibitor: 400740 To be Published
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4JW2
| Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep) | 分子名称: | 1,2-ETHANEDIOL, A3 artificial protein, bA3-2: binder of A3 protein | 著者 | Guellouz, A, Valerio-Lepiniec, M, Urvoas, A, Chevrel, A, Graille, M, Fourati-Kammoun, Z, Desmadril, M, van Tilbeurgh, H, Minard, P. | 登録日 | 2013-03-27 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep). Plos One, 8, 2013
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4JWG
| Crystal structure of spTrm10(74) | 分子名称: | ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase | 著者 | Yan, W, Shao, Z. | 登録日 | 2013-03-27 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4J90
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4JDK
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4K1C
| VCX1 Calcium/Proton Exchanger | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, IODIDE ION, ... | 著者 | Waight, A.B, Pedersen, B.P, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) | 登録日 | 2013-04-04 | 公開日 | 2013-05-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature, 499, 2013
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4JZC
| Angiopoietin-2 fibrinogen domain TAG mutant | 分子名称: | Angiopoietin-2 | 著者 | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | 登録日 | 2013-04-02 | 公開日 | 2013-05-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for angiopoietin-1-mediated signaling initiation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4K0E
| X-ray crystal structure of a heavy metal efflux pump, crystal form II | 分子名称: | Heavy metal cation tricomponent efflux pump ZneA(CzcA-like), ZINC ION | 著者 | Pak, J.E, Ngonlong Ekende, E, Vandenbussche, G, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP) | 登録日 | 2013-04-03 | 公開日 | 2013-10-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.713 Å) | 主引用文献 | Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JZP
| Crystal structure of BAP31 vDED at acidic pH | 分子名称: | B-cell receptor-associated protein 31, SULFATE ION, TETRAETHYLENE GLYCOL | 著者 | Quistgaard, E.M, Low, C, Moberg, P, Guettou, F, Maddi, K, Nordlund, P. | 登録日 | 2013-04-03 | 公開日 | 2013-09-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31. Plos One, 8, 2013
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4K8Z
| KOD Polymerase in binary complex with dsDNA | 分子名称: | 1,2-ETHANEDIOL, COBALT HEXAMMINE(III), DNA (5'-D(*AP*AP*AP*TP*TP*CP*GP*CP*AP*GP*TP*TP*CP*GP*CP*G)-3'), ... | 著者 | Bergen, K, Betz, K, Welte, W, Diederichs, K, Marx, A. | 登録日 | 2013-04-19 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structures of KOD and 9N DNA Polymerases Complexed with Primer Template Duplex Chembiochem, 14, 2013
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4KG4
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4KIE
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4KGF
| Crystal structure of near-infrared fluorescent protein with an extended stokes shift, ph 8.0 | 分子名称: | CHLORIDE ION, TagRFP675, red fluorescent protein | 著者 | Malashkevich, V.N, Piatkevich, K, Almo, S.C, Verkhusha, V, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2013-04-29 | 公開日 | 2013-05-08 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant. Sci Rep, 3, 2013
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4KOE
| Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae | 分子名称: | DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, E-site DNA1, ... | 著者 | Laponogov, I, Pan, X.-S, Veselkov, D.A, Fisher, L.M, Sanderson, M.R. | 登録日 | 2013-05-11 | 公開日 | 2014-11-26 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions To be Published
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4KPF
| Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | 分子名称: | (3aS,4R)-4-amino-13-cyclopropyl-8-fluoro-10-oxo-3a,4,5,6,10,13-hexahydro-1H,3H-pyrrolo[2',1':3,4][1,4]oxazepino[5,6-h]quinoline-11-carboxylic acid, E-site1, E-site2, ... | 著者 | Laponogov, I, Pan, X.-S, Vesekov, D.A, Cirz, R.T, Wagman, A.S, Moser, H.E, Fisher, L.M, Sanderson, M.R. | 登録日 | 2013-05-13 | 公開日 | 2014-11-26 | 最終更新日 | 2018-10-03 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones. Open Biol, 6, 2016
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