7KFA
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![BU of 7kfa by Molmil](/molmil-images/mine/7kfa) | PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Chopra, R, Xu, M, Spraggon, G. | 登録日 | 2020-10-13 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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6YI7
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![BU of 6yi7 by Molmil](/molmil-images/mine/6yi7) | Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with an azanitrile inhibitor | 分子名称: | 1-[(2~{S})-1-[[iminomethyl(methyl)amino]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-(phenylmethyl)urea, ACETATE ION, Cathepsin B-like peptidase (C01 family) | 著者 | Jilkova, A, Rezacova, P, Pachl, P, Fanfrlik, J, Rubesova, P, Guetschow, M, Mares, M. | 登録日 | 2020-04-01 | 公開日 | 2020-12-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity. Acs Infect Dis., 7, 2021
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6YCC
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![BU of 6ycc by Molmil](/molmil-images/mine/6ycc) | Structure the ananain protease from Ananas comosus covalently bound to the E64 inhibitor | 分子名称: | Ananain, GLYCEROL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, ... | 著者 | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | 登録日 | 2020-03-18 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
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6F4P
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![BU of 6f4p by Molmil](/molmil-images/mine/6f4p) | Human JMJD5 in complex with MN, NOG and RPS6 (129-144) (complex-1) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 40S ribosomal protein S6, JmjC domain-containing protein 5, ... | 著者 | Chowdhury, R, Islam, M.S, Schofield, C.J. | 登録日 | 2017-11-29 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | JMJD5 is a human arginyl C-3 hydroxylase. Nat Commun, 9, 2018
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6UZE
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![BU of 6uze by Molmil](/molmil-images/mine/6uze) | Anthrax toxin protective antigen channels bound to edema factor | 分子名称: | CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen | 著者 | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | 登録日 | 2019-11-15 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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6YL4
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![BU of 6yl4 by Molmil](/molmil-images/mine/6yl4) | Soluble epoxide hydrolase in complex with 3-((R)-3-(1-hydroxyureido)but-1-yn-1-yl)-N-((S)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl)benzamide | 分子名称: | 3-[(3~{R})-3-[aminocarbonyl(oxidanyl)amino]but-1-ynyl]-~{N}-[(3~{S})-3-phenyl-3-[4-(trifluoromethyloxy)phenyl]propyl]benzamide, Bifunctional epoxide hydrolase 2 | 著者 | Kramer, J.S, Pogoryelov, D, Hiesinger, K, Proschak, E. | 登録日 | 2020-04-06 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. J.Med.Chem., 63, 2020
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7KEV
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![BU of 7kev by Molmil](/molmil-images/mine/7kev) | PCSK9 in complex with a cyclic peptide LDLR disruptor | 分子名称: | CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ... | 著者 | Spraggon, G, Chopra, R. | 登録日 | 2020-10-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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6UQD
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![BU of 6uqd by Molmil](/molmil-images/mine/6uqd) | |
5T4M
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6M8Y
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![BU of 6m8y by Molmil](/molmil-images/mine/6m8y) | PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIPF | 分子名称: | AIPF PEPTIDE INHIBITOR, CALCIUM ION, CHLORIDE ION, ... | 著者 | Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. | 登録日 | 2018-08-22 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase Biochemistry, 40, 2001
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6M8W
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![BU of 6m8w by Molmil](/molmil-images/mine/6m8w) | PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIAF | 分子名称: | AIAF PEPTIDE INHIBITOR, CALCIUM ION, CHLORIDE ION, ... | 著者 | Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. | 登録日 | 2018-08-22 | 公開日 | 2018-10-24 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase Biochemistry, 40, 2001
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5T4Q
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![BU of 5t4q by Molmil](/molmil-images/mine/5t4q) | Autoinhibited E. coli ATP synthase state 3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Sobti, M, Smits, C, Wong, A.S.W, Ishmukhametov, R, Stock, D, Sandin, S, Stewart, A.G. | 登録日 | 2016-08-29 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (8.53 Å) | 主引用文献 | Cryo-EM structures of the autoinhibitedE. coliATP synthase in three rotational states. Elife, 5, 2016
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7W9S
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![BU of 7w9s by Molmil](/molmil-images/mine/7w9s) | |
7VYZ
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![BU of 7vyz by Molmil](/molmil-images/mine/7vyz) | |
7K51
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![BU of 7k51 by Molmil](/molmil-images/mine/7k51) | Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. | 登録日 | 2020-09-16 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
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7K50
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![BU of 7k50 by Molmil](/molmil-images/mine/7k50) | Pre-translocation non-frameshifting(CCA-A) complex (Structure I) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. | 登録日 | 2020-09-16 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
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7K54
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![BU of 7k54 by Molmil](/molmil-images/mine/7k54) | Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. | 登録日 | 2020-09-16 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
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7K52
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![BU of 7k52 by Molmil](/molmil-images/mine/7k52) | Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. | 登録日 | 2020-09-16 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
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7K55
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![BU of 7k55 by Molmil](/molmil-images/mine/7k55) | Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. | 登録日 | 2020-09-16 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
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6F4Q
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![BU of 6f4q by Molmil](/molmil-images/mine/6f4q) | Human JMJD5 (Q275C) in complex with Mn(II), NOG and RPS6-A138C (129-144) (complex-2) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 40S ribosomal protein S6, GLYCEROL, ... | 著者 | Chowdhury, R, Islam, M.S, Schofield, C.J. | 登録日 | 2017-11-29 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | JMJD5 is a human arginyl C-3 hydroxylase. Nat Commun, 9, 2018
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5T4P
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![BU of 5t4p by Molmil](/molmil-images/mine/5t4p) | Autoinhibited E. coli ATP synthase state 2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Sobti, M, Smits, C, Wong, A.S.W, Ishmukhametov, R, Stock, D, Sandin, S, Stewart, A.G. | 登録日 | 2016-08-29 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.77 Å) | 主引用文献 | Cryo-EM structures of the autoinhibitedE. coliATP synthase in three rotational states. Elife, 5, 2016
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7K81
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![BU of 7k81 by Molmil](/molmil-images/mine/7k81) | KIR3DL1*005 in complex with HLA-A*24:02 presenting the RYPLTFGW peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ARG-TYR-PRO-LEU-THR-PHE-GLY-TRP, Beta-2-microglobulin, ... | 著者 | MacLachlan, B.J, Rossjohn, J, Vivian, J.P. | 登録日 | 2020-09-24 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Role of the HLA Class I alpha 2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1. J Immunol., 206, 2021
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6MHE
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![BU of 6mhe by Molmil](/molmil-images/mine/6mhe) | Galphai3 co-crystallized with KB752 | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, ... | 著者 | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | 登録日 | 2018-09-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6VHL
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![BU of 6vhl by Molmil](/molmil-images/mine/6vhl) | Paired Helical Filament from Alzheimer's Disease Human Brain Tissue | 分子名称: | GLYCINE, Microtubule-associated protein tau | 著者 | Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. | 登録日 | 2020-01-10 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell, 180, 2020
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6MMR
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![BU of 6mmr by Molmil](/molmil-images/mine/6mmr) | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.13 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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