PDB: 19040 件ウェブページステータス検索Chemie searchBIRD

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8G60	mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) 分子名称: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... 著者 Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. 登録日 2023-02-14 公開日 2023-04-19 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8G61	mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) 分子名称: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... 著者 Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. 登録日 2023-02-14 公開日 2023-04-19 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8J4T	GajA-GajB complex 分子名称: Endonuclease GajA, Gabija protein GajB 著者 Wei, T, Ma, J, Huo, Y. 登録日 2023-04-20 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system. Nat Commun, 15, 2024
3H57	Myoglobin Cavity Mutant H64LV68N Deoxy form 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Soman, J, Olson, J.S. 登録日 2009-04-21 公開日 2009-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Optical detection of disordered water within a protein cavity. J.Am.Chem.Soc., 131, 2009
3ISW	Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR 分子名称: Cystic fibrosis transmembrane conductance regulator, Filamin-A 著者 Xu, Z, Page, R, Qin, J, Ithychanda, S.S, Liu, J.M, Misra, S. 登録日 2009-08-27 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin. J.Biol.Chem., 285, 2010
3IXC	Crystal structure of hexapeptide transferase family protein from Anaplasma phagocytophilum 分子名称: Hexapeptide transferase family protein, MAGNESIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-09-03 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Crystal structure of hexapeptide transferase family protein from Anaplasma phagocytophilum To be Published
3AL3	Crystal Structure of TopBP1 BRCT7/8-BACH1 peptide complex 分子名称: DNA topoisomerase 2-binding protein 1, FORMIC ACID, Peptide of Fanconi anemia group J protein 著者 Leung, C.C, Glover, J.N. 登録日 2010-07-22 公開日 2010-12-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control J.Biol.Chem., 286, 2011
3AST	Crystal structure of P domain Q389N mutant from Norovirus Funabashi258 stain in the complex with Lewis-b 分子名称: Capsid protein, P-NITROPHENOL, SODIUM ION, ... 著者 Kubota, T, Kumagai, A, Itoh, H, Furukawa, S, Narimatsu, H, Wakita, T, Ishii, K, Takeda, N, Someya, Y, Shirato, H. 登録日 2010-12-17 公開日 2012-01-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural basis for the recognition of Lewis antigens by genogroup I norovirus J.Virol., 86, 2012
5OD6	Crystal structure of Smad3-MH1 bound to the GGCGC site. 分子名称: DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 3, ZINC ION 著者 Kaczmarska, Z, Marquez, J.A, Macias, M.J. 登録日 2017-07-04 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
1L6O	XENOPUS DISHEVELLED PDZ DOMAIN 分子名称: Dapper 1, Segment polarity protein dishevelled homolog DVL-2 著者 Cheyette, B.N.R, Waxman, J.S, Miller, J.R, Takemaru, K.-I, Sheldahl, L.C, Khlebtsova, N, Fox, E.P, Earnest, T, Moon, R.T. 登録日 2002-03-11 公開日 2003-06-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation Dev.Cell, 2, 2002
5ODG	Crystal structure of Smad3-MH1 bound to the GGCT site. 分子名称: CHLORIDE ION, DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), Mothers against decapentaplegic homolog 3, ... 著者 Kaczmarska, Z, Marquez, J.A, Macias, M.J. 登録日 2017-07-05 公開日 2017-11-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
3EMU	Crystal structure of a leucine rich repeat and phosphatase domain containing protein from Entamoeba histolytica 分子名称: SULFATE ION, leucine rich repeat and phosphatase domain containing protein 著者 Bonanno, J.B, Gilmore, M, Bain, K.T, Hu, S, Ozyurt, S, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2008-09-25 公開日 2008-10-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of a leucine rich repeat and phosphatase domain containing protein from Entamoeba histolytica To be Published
7ORF	Crystal structure of JNK3 in complex with FMU-001-367 (compound 1) 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 10, ... 著者 Chaikuad, A, Koch, P, Laufer, S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-06-05 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angew.Chem.Int.Ed.Engl., 60, 2021
7ORE	Crystal structure of JNK3 in complex with light-activated covalent inhibitor MR-II-249 with both non-covalent and covalent binding modes (compound 4) 分子名称: 1,2-ETHANEDIOL, 4-(dimethylamino)-N-[(5Z)-9-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]-11,12-dihydrobenzo[c][1,2]benzodiazocin-2-yl]butanamide, Mitogen-activated protein kinase 10 著者 Chaikuad, A, Reynders, M, Trauner, D, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-06-05 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angew.Chem.Int.Ed.Engl., 60, 2021
7OVK	Protein kinase MKK7 in complex with 5-bromo-2-hydroxyphenyl-substituted pyrazolopyrimidine 分子名称: 1-[(3~{R})-3-[4-azanyl-3-[1-(5-bromanyl-2-oxidanyl-phenyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL 著者 Kleinboelting, S, Buehrmann, M, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
7OVM	Protein kinase MKK7 in complex with cyclobutyl-substituted indazole 分子名称: Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[(1-cyclobutyl-1,2,3-triazol-4-yl)methyl]-3-(1~{H}-indazol-3-yl)-5-(propanoylamino)benzamide 著者 Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
7OVN	Protein kinase MKK7 in complex with tolyl-substituted indazole 分子名称: 3-(1~{H}-indazol-3-yl)-~{N}-[[1-(2-methylphenyl)-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide, Dual specificity mitogen-activated protein kinase kinase 7 著者 Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
7OVJ	Protein kinase MKK7 in complex with difluoro-phenethyltriazole-substituted pyrazolopyrimidine 分子名称: 1-[(3~{R})-3-[4-azanyl-3-[1-[2,2-bis(fluoranyl)-2-phenyl-ethyl]-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
7OVL	Protein kinase MKK7 in complex with methoxycyclohexyl-substituted indazole 分子名称: 3-(2~{H}-indazol-3-yl)-~{N}-[[1-[(1~{R},2~{R})-2-methoxycyclohexyl]-1,2,3-triazol-4-yl]methyl]-5-(propanoylamino)benzamide, Dual specificity mitogen-activated protein kinase kinase 7 著者 Buehrmann, M, Wiese, J.N, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
7OVI	Protein kinase MKK7 in complex with phenethyltriazole-substituted pyrazolopyrimidine 分子名称: 1-[(3~{R})-3-[4-azanyl-3-[1-(2-phenylethyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Kleinboelting, S, Buehrmann, M, Mueller, M.P, Rauh, D. 登録日 2021-06-15 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries. J.Med.Chem., 65, 2022
4NR6	Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand 分子名称: 1-[7-(3,4-dimethoxyphenyl)-9-{[(3R)-1-methylpiperidin-3-yl]methoxy}-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]propan-1-one, CREB-binding protein 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Hay, D, Fedorov, O, Martin, S, Chaikuad, A, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-26 公開日 2013-12-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand To be Published
4NIN	DSVISLS segment 101-107 from Human Superoxide Dismutase 分子名称: DSVISLS segment from Superoxide dismutase [Cu-Zn], ZINC ION 著者 Sievers, S.A, Sawaya, M.R, Eisenberg, D. 登録日 2013-11-06 公開日 2013-12-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.402 Å) 主引用文献 Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc.Natl.Acad.Sci.USA, 111, 2014
4NIO	GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis 分子名称: GVTGIAQ segment from Superoxide dismutase [Cu-Zn] 著者 Sievers, S.A, Sawaya, M.R, Eisenberg, D, Ivanova, M.I. 登録日 2013-11-06 公開日 2013-12-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc.Natl.Acad.Sci.USA, 111, 2014
4NQN	Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand 分子名称: 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, Bromodomain-containing protein 9 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-11-25 公開日 2013-12-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand To be Published
4NKL	Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92Q at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Caro, J.A, Sorenson, J.L, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-11-12 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Pressure effects in proteins To be Published

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