7ORF
Crystal structure of JNK3 in complex with FMU-001-367 (compound 1)
Summary for 7ORF
Entry DOI | 10.2210/pdb7orf/pdb |
Descriptor | Mitogen-activated protein kinase 10, N-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, mapk, mapk10, light activation, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 44164.02 |
Authors | Chaikuad, A.,Koch, P.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-06-05, release date: 2021-07-21, Last modification date: 2024-01-31) |
Primary citation | Reynders, M.,Chaikuad, A.,Berger, B.T.,Bauer, K.,Koch, P.,Laufer, S.,Knapp, S.,Trauner, D. Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angew.Chem.Int.Ed.Engl., 60:20178-20183, 2021 Cited by PubMed: 34081840DOI: 10.1002/anie.202103767 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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