4NR6

Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand

Summary for 4NR6

• Entry DOI: 10.2210/pdb4nr6/pdb
• Related: 4NR4 4NR5 4NR7
• Descriptor: CREB-binding protein, 1-[7-(3,4-dimethoxyphenyl)-9-{[(3R)-1-methylpiperidin-3-yl]methoxy}-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]propan-1-one (3 entities in total)
• Functional Keywords: structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14691.93

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Chaikuad, A.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Chaikuad, A.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.66 Å)