4NR5

Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand

Summary for 4NR5

• Entry DOI: 10.2210/pdb4nr5/pdb
• Related: 4NR4 4NR6 4NR7
• Descriptor: CREB-binding protein, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, NITRATE ION, ... (5 entities in total)
• Functional Keywords: structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14777.96

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Pike, A.W.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Pike, A.W.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.66 Å)