4NR6
Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand
Summary for 4NR6
Entry DOI | 10.2210/pdb4nr6/pdb |
Related | 4NR4 4NR5 4NR7 |
Descriptor | CREB-binding protein, 1-[7-(3,4-dimethoxyphenyl)-9-{[(3R)-1-methylpiperidin-3-yl]methoxy}-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]propan-1-one (3 entities in total) |
Functional Keywords | structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14691.93 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Chaikuad, A.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-18, Last modification date: 2023-09-20) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Chaikuad, A.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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