6U8V
 
 | | Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA | | 分子名称: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | | 著者 | Gao, L, Zhang, Z.M, Song, J. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Nat Commun, 11, 2020
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6EB6
 | | Crystal structure of BAX W139A monomer | | 分子名称: | Apoptosis regulator BAX, FORMIC ACID | | 著者 | Robin, A.Y. | | 登録日 | 2018-08-05 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.023 Å) | | 主引用文献 | BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Cell Rep, 27, 2019
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5TZN
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6U8W
 | | Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA | | 分子名称: | CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... | | 著者 | Gao, L, Zhang, Z.M, Song, J. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.94891548 Å) | | 主引用文献 | Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Nat Commun, 11, 2020
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6U9D
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6X6N
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6L1U
 | | Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril | | 分子名称: | Alpha-synuclein | | 著者 | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | | 登録日 | 2019-09-30 | | 公開日 | 2020-08-12 | | 最終更新日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6UJQ
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6Y23
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7VOK
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7KMY
 | | Structure of Mtb Lpd bound to 010705 | | 分子名称: | Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Lima, C.D. | | 登録日 | 2020-11-03 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
Acs Infect Dis., 7, 2021
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6F4M
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6F4T
 | | Human JMJD5 (W414C) in complex with Mn(II), NOG and RCCD1 (139-143) (complex-5) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, JmjC domain-containing protein 5, ... | | 著者 | Chowdhury, R, Islam, M.S, Schofield, C.J. | | 登録日 | 2017-11-30 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
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6TXE
 | | Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. | | 登録日 | 2020-01-14 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
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6TXA
 | | Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dGMPNPP and Mg | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A. | | 登録日 | 2020-01-13 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.853 Å) | | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
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5U1Z
 | | X-ray structure of the WlarG aminotransferase, apo form, from Campylobacter jejune | | 分子名称: | CHLORIDE ION, Putative aminotransferase, SODIUM ION | | 著者 | Holden, H.M, Thoden, J.B, Dow, G.T, Gilbert, M. | | 登録日 | 2016-11-29 | | 公開日 | 2017-01-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase.
Protein Sci., 26, 2017
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6L8Q
 | | Complex structure of bat CD26 and MERS-RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | | 著者 | Yuan, Y. | | 登録日 | 2019-11-07 | | 公開日 | 2019-12-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species.
J.Virol., 94, 2020
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6UT9
 | | Crystal structure of the carbohydrate-binding domain VP8* of human P[4] rotavirus strain BM5265 | | 分子名称: | Outer capsid protein VP4 | | 著者 | Xu, S, Stuckert, M, Burnside, R, McGinnis, K, Jiang, X, Kennedy, M.A. | | 登録日 | 2019-10-29 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6F4N
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6VH7
 | | Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue | | 分子名称: | Microtubule-associated protein tau | | 著者 | Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. | | 登録日 | 2020-01-09 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains.
Cell, 180, 2020
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6V0V
 | | Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0) | | 分子名称: | CALCIUM ION, DNA (30-MER), V(D)J recombination-activating protein 1, ... | | 著者 | Chen, X, Yang, W, Gellert, M. | | 登録日 | 2019-11-19 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
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5U20
 | | X-ray structure of the WlaRG aminotransferase from Campylobacter jejuni, internal PLP-aldimine | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Putative aminotransferase, ... | | 著者 | Thoden, J.B, Holden, H.M, Dow, G.T, Gilbert, M. | | 登録日 | 2016-11-29 | | 公開日 | 2017-01-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase.
Protein Sci., 26, 2017
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6YCF
 | | Structure the bromelain protease from Ananas comosus in complex with the E64 inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, FBSB, ... | | 著者 | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | 登録日 | 2020-03-18 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6F4S
 | | Human JMJD5 (N308C) in complex with Mn(II), 2OG and RCCD1 (139-143) (complex-4) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-OXOGLUTARIC ACID, GLYCEROL, ... | | 著者 | Chowdhury, R, Islam, M.S, Schofield, C.J. | | 登録日 | 2017-11-30 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.461 Å) | | 主引用文献 | JMJD5 is a human arginyl C-3 hydroxylase.
Nat Commun, 9, 2018
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5UGG
 | | Protease Inhibitor | | 分子名称: | Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen | | 著者 | Law, R.H.P, Wu, G, Whisstock, J.C. | | 登録日 | 2017-01-08 | | 公開日 | 2017-05-31 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
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