7KMY

Structure of Mtb Lpd bound to 010705

Summary for 7KMY

• Entry DOI: 10.2210/pdb7kmy/pdb
• Related: 4M52
• Descriptor: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-methyl-N~2~-[(5-methyl-1H-indazol-7-yl)sulfonyl]-N-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)glycinamide, ... (5 entities in total)
• Functional Keywords: flavoprotein, glycolysis, redox-active center, inhibitor, oxidoreductase/oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 8
• Total formula weight: 408303.59

Authors

Lima, C.D. (deposition date: 2020-11-03, release date: 2021-01-27, Last modification date: 2023-10-18)

• Primary citation: Ginn, J.,Jiang, X.,Sun, S.,Michino, M.,Huggins, D.J.,Mbambo, Z.,Jansen, R.,Rhee, K.Y.,Arango, N.,Lima, C.D.,Liverton, N.,Imaeda, T.,Okamoto, R.,Kuroita, T.,Aso, K.,Stamford, A.,Foley, M.,Meinke, P.T.,Nathan, C.,Bryk, R.; Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.; Acs Infect Dis., 7:435-444, 2021; PubMed: 33527832; DOI: 10.1021/acsinfecdis.0c00788

Experimental method

X-RAY DIFFRACTION (2.21 Å)