4M52
Structure of Mtb Lpd bound to SL827
Summary for 4M52
Entry DOI | 10.2210/pdb4m52/pdb |
Related | 2A8X 3II4 |
Descriptor | Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-[(2-amino-5-bromopyridin-3-yl)sulfonyl]-N-(4-methoxyphenyl)-N~2~-methylglycinamide, ... (4 entities in total) |
Functional Keywords | oxidoreductase, flavoprotein, glycolysis, redox-active center |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P66004 |
Total number of polymer chains | 4 |
Total formula weight | 202607.50 |
Authors | Lima, C.D. (deposition date: 2013-08-07, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Bryk, R.,Arango, N.,Maksymiuk, C.,Balakrishnan, A.,Wu, Y.T.,Wong, C.H.,Masquelin, T.,Hipskind, P.,Lima, C.D.,Nathan, C. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry, 52:9375-9384, 2013 Cited by PubMed: 24251446DOI: 10.1021/bi401077f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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