4M52

Structure of Mtb Lpd bound to SL827

Summary for 4M52

• Entry DOI: 10.2210/pdb4m52/pdb
• Related: 2A8X 3II4
• Descriptor: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-[(2-amino-5-bromopyridin-3-yl)sulfonyl]-N-(4-methoxyphenyl)-N~2~-methylglycinamide, ... (4 entities in total)
• Functional Keywords: oxidoreductase, flavoprotein, glycolysis, redox-active center
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (Potential): P66004
• Total number of polymer chains: 4
• Total formula weight: 202607.50

Authors

Lima, C.D. (deposition date: 2013-08-07, release date: 2013-11-27, Last modification date: 2023-09-20)

• Primary citation: Bryk, R.,Arango, N.,Maksymiuk, C.,Balakrishnan, A.,Wu, Y.T.,Wong, C.H.,Masquelin, T.,Hipskind, P.,Lima, C.D.,Nathan, C.; Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.; Biochemistry, 52:9375-9384, 2013; PubMed: 24251446; DOI: 10.1021/bi401077f

Experimental method

X-RAY DIFFRACTION (2.4 Å)