7KMY

Structure of Mtb Lpd bound to 010705

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
A	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0015036	molecular_function	disulfide oxidoreductase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0035375	molecular_function	zymogen binding
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0045454	biological_process	cell redox homeostasis
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0070404	molecular_function	NADH binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
B	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0015036	molecular_function	disulfide oxidoreductase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0035375	molecular_function	zymogen binding
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0045454	biological_process	cell redox homeostasis
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0070404	molecular_function	NADH binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
C	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0015036	molecular_function	disulfide oxidoreductase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0035375	molecular_function	zymogen binding
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0045454	biological_process	cell redox homeostasis
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0070404	molecular_function	NADH binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
D	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0015036	molecular_function	disulfide oxidoreductase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0035375	molecular_function	zymogen binding
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0045454	biological_process	cell redox homeostasis
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0070404	molecular_function	NADH binding
D	0098869	biological_process	cellular oxidant detoxification
I	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
I	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006103	biological_process	2-oxoglutarate metabolic process
I	0015036	molecular_function	disulfide oxidoreductase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
I	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
I	0035375	molecular_function	zymogen binding
I	0045254	cellular_component	pyruvate dehydrogenase complex
I	0045454	biological_process	cell redox homeostasis
I	0050660	molecular_function	flavin adenine dinucleotide binding
I	0070404	molecular_function	NADH binding
I	0098869	biological_process	cellular oxidant detoxification
J	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
J	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006103	biological_process	2-oxoglutarate metabolic process
J	0015036	molecular_function	disulfide oxidoreductase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
J	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
J	0035375	molecular_function	zymogen binding
J	0045254	cellular_component	pyruvate dehydrogenase complex
J	0045454	biological_process	cell redox homeostasis
J	0050660	molecular_function	flavin adenine dinucleotide binding
J	0070404	molecular_function	NADH binding
J	0098869	biological_process	cellular oxidant detoxification
M	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
M	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006103	biological_process	2-oxoglutarate metabolic process
M	0015036	molecular_function	disulfide oxidoreductase activity
M	0016209	molecular_function	antioxidant activity
M	0016491	molecular_function	oxidoreductase activity
M	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
M	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
M	0035375	molecular_function	zymogen binding
M	0045254	cellular_component	pyruvate dehydrogenase complex
M	0045454	biological_process	cell redox homeostasis
M	0050660	molecular_function	flavin adenine dinucleotide binding
M	0070404	molecular_function	NADH binding
M	0098869	biological_process	cellular oxidant detoxification
N	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
N	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006103	biological_process	2-oxoglutarate metabolic process
N	0015036	molecular_function	disulfide oxidoreductase activity
N	0016209	molecular_function	antioxidant activity
N	0016491	molecular_function	oxidoreductase activity
N	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
N	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
N	0035375	molecular_function	zymogen binding
N	0045254	cellular_component	pyruvate dehydrogenase complex
N	0045454	biological_process	cell redox homeostasis
N	0050660	molecular_function	flavin adenine dinucleotide binding
N	0070404	molecular_function	NADH binding
N	0098869	biological_process	cellular oxidant detoxification

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGvCLnvGCIP

Chain	Residue	Details
A	GLY38-PRO48

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16093239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20078138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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