7K5I
 
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4UX3
 | | cohesin Smc3-HD:Scc1-N complex from yeast | | 分子名称: | MAGNESIUM ION, MITOTIC CHROMOSOME DETERMINANT-RELATED PROTEIN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Gligoris, T.G, Nasmyth, K, Lowe, J. | | 登録日 | 2014-08-18 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Closing the Cohesin Ring: Structure and Function of its Smc3-Kleisin Interface.
Science, 346, 2014
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6GGH
 | | Human jak1 kinase domain in complex with inhibitor | | 分子名称: | Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | | 著者 | Read, J.A, Augustin, M, Lammens, A. | | 登録日 | 2018-05-03 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling
To Be Published
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4X12
 | | JC Polyomavirus genotype 3 VP1 in complex with GD1b oligosaccharide | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Major capsid protein, ... | | 著者 | Stroh, L.J, Stehle, T. | | 登録日 | 2014-11-24 | | 公開日 | 2015-04-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Greater Affinity of JC Polyomavirus Capsid for alpha 2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity.
J.Virol., 89, 2015
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8G2M
 | | The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer | | 分子名称: | CITRIC ACID, Heavy chain of humanized IgG, Light chain of humanized IgG, ... | | 著者 | Williams, J.C, Williams, J.C. | | 登録日 | 2023-02-05 | | 公開日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
J Immunother Cancer, 11, 2023
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1EGN
 | | CELLOBIOHYDROLASE CEL7A (E223S, A224H, L225V, T226A, D262G) MUTANT | | 分子名称: | 1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE CEL7A, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION | | 著者 | Stahlberg, J, Harris, M, Jones, T.A. | | 登録日 | 2000-02-16 | | 公開日 | 2001-05-16 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Engineering of a glycosidase Family 7 cellobiohydrolase to more alkaline pH optimum: the pH behaviour of Trichoderma reesei Cel7A and its E223S/ A224H/L225V/T226A/D262G mutant.
Biochem.J., 356, 2001
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2R8F
 | | Crystal structure of H225A NSP2 and ATP-gS complex | | 分子名称: | Non-structural RNA-binding protein 35, PHOSPHATE ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Kumar, M, Prasad, B.V.V. | | 登録日 | 2007-09-10 | | 公開日 | 2007-10-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity
J.Virol., 81, 2007
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2ROY
 | | TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE | | 分子名称: | 3',5'-DINITRO-N-ACETYL-L-THYRONINE, TRANSTHYRETIN | | 著者 | Wojtczak, A, Cody, V, Luft, J.R, Pangborn, W. | | 登録日 | 1996-10-23 | | 公開日 | 1997-04-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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9ARF
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in nonactive1 conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Chou, T.-H, Furukawa, H. | | 登録日 | 2024-02-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9ARH
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9ARG
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9ARI
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9ARE
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation | | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | | 著者 | Chou, T.-H, Furukawa, H. | | 登録日 | 2024-02-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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2ROX
 | | TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH THYROXINE (T4) | | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, SULFATE ION, TRANSTHYRETIN | | 著者 | Wojtczak, A, Cody, V, Luft, J.R, Pangborn, W. | | 登録日 | 1996-10-23 | | 公開日 | 1997-04-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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7SJG
 | | Structure of Dehaloperoxidase B in Complex with Thymoquinone | | 分子名称: | (6R)-4-hydroxy-6-methyl-3-(propan-2-yl)cyclohexa-2,4-dien-1-one, 2-methyl-5-(propan-2-yl)benzene-1,4-diol, Dehaloperoxidase B, ... | | 著者 | Ghiladi, R.A, de Serrano, V.S, Malewschik, T, Yun, D. | | 登録日 | 2021-10-17 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Multifunctional Globin Dehaloperoxidase as a Biocatalyst in the Oxidation of Monoterpenes
To Be Published
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7SJH
 | | Crystal structure of dehaloperoxidase B in complex with S-(-)-limonene | | 分子名称: | (4S)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene, Dehaloperoxidase B, GLYCEROL, ... | | 著者 | Ghiladi, R.A, de Serrano, V.S, Malewschik, T, Yun, D. | | 登録日 | 2021-10-17 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | The Multifunctional Globin Dehaloperoxidase as a Biocatalyst in the Oxidation of Monoterpenes
To Be Published
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7SJF
 | | Structure of Dehaloperoxidase B in Complex with Thymol | | 分子名称: | 5-METHYL-2-(1-METHYLETHYL)PHENOL, Dehaloperoxidase B, GLYCEROL, ... | | 著者 | Ghiladi, R.A, de Serrano, V.S, Malewschik, T, Yun, D. | | 登録日 | 2021-10-17 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | The Multifunctional Globin Dehaloperoxidase as a Biocatalyst in the Oxidation of Monoterpenes
To Be Published
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7ZR1
 | | Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) | | 分子名称: | DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... | | 著者 | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | | 登録日 | 2022-05-03 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Mol.Cell, 83, 2023
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6DJV
 | | Mtb ClpB in complex with ATPgammaS and casein, Conformer 2 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Yu, H.J, Li, H.L. | | 登録日 | 2018-05-26 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DJU
 | | Mtb ClpB in complex with ATPgammaS and casein, Conformer 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Yu, H.J, Li, H.L. | | 登録日 | 2018-05-26 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8XOJ
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1 | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
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8XOH
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of E2 | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
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8XOG
 | | Cryo-EM structure of apo-GPR30-Gq complex structure | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
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8XOF
 | | Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | | 分子名称: | G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
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8XOI
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
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