8T35
 
 | | Crystal structure of K51 acetylated LC3A in complex with the LIR of TP53INP2/DOR | | 分子名称: | 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A | | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | 登録日 | 2023-06-07 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 20, 2024
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5EOJ
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5EZ3
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6FPL
 | | TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ... | | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | | 登録日 | 2018-02-11 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
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6Q4B
 | | CDK2 in complex with FragLite13 | | 分子名称: | 5-bromanylpyrimidine, Cyclin-dependent kinase 2 | | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | | 登録日 | 2018-12-05 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
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6Q4J
 | | CDK2 in complex with FragLite34 | | 分子名称: | 2-[3-(pyrimidin-4-ylamino)phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE | | 著者 | Wood, D.J, Martin, M.P, Noble, M.E.M. | | 登録日 | 2018-12-05 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
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8T36
 | | Crystal structure of K49 acetylated LC3A in complex with the LIR of TP53INP2/DOR | | 分子名称: | 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A chimera | | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | 登録日 | 2023-06-07 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.852 Å) | | 主引用文献 | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 20, 2024
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8T31
 | | Crystal structure of GABARAP in complex with the LIR of TP53INP2/DOR | | 分子名称: | Gamma-aminobutyric acid receptor-associated protein, Tumor protein p53-inducible nuclear protein 2 | | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | 登録日 | 2023-06-07 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | | 主引用文献 | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 20, 2024
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7ZD4
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6FS8
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5EZD
 | | Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 | | 分子名称: | ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION | | 著者 | Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K. | | 登録日 | 2015-11-26 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
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4TRM
 | | Structure of the apo form of InhA from Mycobacterium tuberculosis | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Enoyl-[acyl-carrier-protein] reductase [NADH] | | 著者 | Chollet, A, Julien, S, Mourey, L, Maveyraud, L. | | 登録日 | 2014-06-17 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
J.Struct.Biol., 190, 2015
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6M2F
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6FVI
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6MAR
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6FR4
 | | 003 TCR Study of CDR Loop Flexibility | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Cole, D.K. | | 登録日 | 2018-02-15 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | In Silicoand Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Front Immunol, 9, 2018
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5F07
 | | Crystal structure of glutathione transferase F8 from Populus trichocarpa | | 分子名称: | GLUTATHIONE, Putative glutathione S-transferase family protein | | 著者 | Didierjean, C, Rouhier, N, Pegeot, H, Gense, F. | | 登録日 | 2015-11-27 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural plasticity among glutathione transferase Phi members: natural combination of catalytic residues confers dual biochemical activities.
FEBS J., 284, 2017
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8TC5
 | | Cryo-EM Structure of Spike Glycoprotein from Civet Coronavirus SZ3 in Closed Conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bostina, M, Hills, F.R, Eruera, A. | | 登録日 | 2023-06-29 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Variation in structural motifs within SARS-related coronavirus spike proteins.
Plos Pathog., 20, 2024
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7YTY
 | | Mouse SVCT1 in an apo state | | 分子名称: | Solute carrier family 23 member 1 | | 著者 | She, J, Wang, M, He, J, Zhang, K, Li, S. | | 登録日 | 2022-08-16 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
Nat Commun, 14, 2023
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8WDM
 | | Crystal structure of a novel PU plastic degradation enzyme from Thermaerobacter marianensis | | 分子名称: | Carboxylic ester hydrolase | | 著者 | Li, Z.S, Wang, H, Gao, J, Chen, Y.Y, Wei, H.L, Li, Q, Han, X, Wei, R, Liu, W.D. | | 登録日 | 2023-09-15 | | 公開日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a novel PU plastic degradation enzyme from Thermaerobacter marianensis
To Be Published
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8XGK
 | | Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Ihhibitors | | 分子名称: | (2~{R},3~{S})-3-[[(2~{S})-2-(4-chlorophenyl)-2-fluoranyl-ethanoyl]amino]-3-[3-(2-cyano-2-methyl-propoxy)-4-methyl-phenyl]-2-methyl-propanoic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ... | | 著者 | Otake, K, Hara, Y, Ubukata, M, Inoue, M, Nagahashi, N, Motoda, D, Ogawa, N, Hantani, Y, Hantani, R, Adachi, T, Nomura, A, Yamaguchi, K, Maekawa, M, Mamada, H, Motomura, T, Sato, M, Harada, K. | | 登録日 | 2023-12-15 | | 公開日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
J.Med.Chem., 67, 2024
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4RKE
 | | Drosophila melanogaster Rab2 bound to GMPPNP | | 分子名称: | GH01619p, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | | 著者 | Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. | | 登録日 | 2014-10-13 | | 公開日 | 2014-12-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.0006 Å) | | 主引用文献 | Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.
Acta Crystallogr F Struct Biol Commun, 71, 2015
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6M95
 | | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 | | 分子名称: | (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 | | 著者 | Lane, W, Okada, K. | | 登録日 | 2018-08-22 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.
Chemmedchem, 14, 2019
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7ZED
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6FYB
 | | The crystal structure of EncM L144M mutant | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative FAD-dependent oxygenase EncM | | 著者 | Saleem-Batcha, R, Teufel, R. | | 登録日 | 2018-03-11 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | | 主引用文献 | Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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