8HK9
 
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8HK6
 | | potassium channel | | 分子名称: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | | 著者 | Jiang, D.H, Zhang, J.T. | | 登録日 | 2022-11-25 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HJZ
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8HJY
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8HJX
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8HJO
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8HJL
 | | Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with M3E | | 分子名称: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(3S,8S,9R,10S,11S,13R,14S,17S)-17-[(2S,5R)-5-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-6-oxidanyl-heptan-2-yl]-4,4,9,13,14-pentamethyl-11-oxidanyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-3,4,5-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Li, M, Zhang, S, Cui, S. | | 登録日 | 2022-11-23 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural insights into the catalytic selectivity of SgUGT94-289-3 towards mogrosides
To Be Published
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8HJH
 | | Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with SIA, state 3 | | 分子名称: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, (2S,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2S,3S,4S,5R,6S)-5-[(2S,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-[(3R,6S)-6-[(3S,8S,9R,10R,11S,13R,14S,17R)-3-[(2S,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,4,9,13,14-pentamethyl-11-oxidanyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-2-oxidanyl-heptan-3-yl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methoxy]oxane-3,4,5-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Li, M, Zhang, S, Cui, S. | | 登録日 | 2022-11-23 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural insights into the catalytic selectivity of SgUGT94-289-3 towards mogrosides
To Be Published
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8HJG
 | | Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with M5, state 1 | | 分子名称: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, (2S,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2R,3S,4S,5R,6R)-6-[[(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2S,5R)-5-[(2S,3R,4S,5S,6R)-3-[(2R,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-6-oxidanyl-heptan-2-yl]-4,4,9,13,14-pentamethyl-11-oxidanyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methoxy]oxane-3,4,5-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Li, M, Zhang, S, Cui, S. | | 登録日 | 2022-11-23 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insights into the catalytic selectivity of SgUGT94-289-3 towards mogrosides
To Be Published
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8HJF
 | | Crystal structure of glycosyltransferase SgUGT94-289-3 in complex with M5, state 2 | | 分子名称: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, (2S,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2R,3S,4S,5R,6R)-6-[[(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2S,5R)-5-[(2S,3R,4S,5S,6R)-3-[(2R,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-6-oxidanyl-heptan-2-yl]-4,4,9,13,14-pentamethyl-11-oxidanyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methoxy]oxane-3,4,5-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Li, M, Zhang, S, Cui, S. | | 登録日 | 2022-11-23 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the catalytic selectivity of SgUGT94-289-3 towards mogropides
To Be Published
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8HJE
 | | Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28 | | 分子名称: | 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28 | | 著者 | Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N. | | 登録日 | 2022-11-23 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Eur.J.Med.Chem., 254, 2023
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8HJB
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8HJA
 | | The crystal structure of syn_CdgR-(c-di-GMP) from Synechocystis sp. PCC 6803 | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), c-di-GMP receptor | | 著者 | Zeng, X, Peng, Y.J. | | 登録日 | 2022-11-22 | | 公開日 | 2023-03-29 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | A c-di-GMP binding effector controls cell size in a cyanobacterium.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8HJ9
 | | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | | 分子名称: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | | 登録日 | 2022-11-22 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy.
Febs J., 290, 2023
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8HJ5
 | | Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | Gan, B, Yu, L.Y, Ren, R.B. | | 登録日 | 2022-11-22 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.
Plos Biol., 21, 2023
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8HJ3
 | | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | | 分子名称: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | | 登録日 | 2022-11-22 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy.
Febs J., 290, 2023
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8HIZ
 | | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | | 分子名称: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | | 登録日 | 2022-11-22 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy.
Febs J., 290, 2023
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8HIT
 | | Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 | | 分子名称: | Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL | | 著者 | Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J. | | 登録日 | 2022-11-21 | | 公開日 | 2023-02-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.
Mabs, 15, 2023
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8HIS
 | | Crystal structure of DNA decamer containing GuNA[Me,tBu] | | 分子名称: | CACODYLIC ACID, DNA (5'-D(*GP*CP*GP*TP*AP*(LR6)P*AP*CP*GP*C)-3') | | 著者 | Aoyama, H, Obika, S, Yamaguchi, T. | | 登録日 | 2022-11-21 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N'- methylguanidine-bridged nucleic acids.
Nucleic Acids Res., 51, 2023
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8HIR
 | | potassium channels | | 分子名称: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | | 著者 | Jiang, D.H, Zhang, J.T. | | 登録日 | 2022-11-21 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HIQ
 | | cryoEM structure of glutamate dehydrogenase from Thermococcus profundus in complex with NADP | | 分子名称: | Glutamate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wakabayashi, T, Oide, M, Kato, T, Nakasako, M. | | 登録日 | 2022-11-21 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy.
Febs J., 290, 2023
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8HIP
 | | dsRNA transporter | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Systemic RNA interference defective protein 1, ZINC ION, ... | | 著者 | Jiang, D.H, Zhang, J.T. | | 登録日 | 2022-11-21 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structural insights into double-stranded RNA recognition and transport by SID-1.
Nat.Struct.Mol.Biol., 2024
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8HIO
 | | Cryo-EM structure of the Cas12m2-crRNA binary complex | | 分子名称: | Cas12m2, MAGNESIUM ION, RNA (56-MER), ... | | 著者 | Omura, N.S, Nakagawa, R, Wu, Y.W, Sudfeld, C, Warren, V.R, Hirano, H, Kusakizako, T, Kise, Y, Lebbink, H.G.J, Itoh, Y, Oost, V.D.J, Nureki, O. | | 登録日 | 2022-11-21 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme.
Nat.Struct.Mol.Biol., 30, 2023
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8HIN
 | | Structure of human SGLT2-MAP17 complex with Phlorizin | | 分子名称: | 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, PDZK1-interacting protein 1, ... | | 著者 | Hiraizumi, M, Kishida, H, Miyaguchi, I, Nureki, O. | | 登録日 | 2022-11-21 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Nat.Struct.Mol.Biol., 31, 2024
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8HIF
 | | One asymmetric unit of Singapore grouper iridovirus capsid | | 分子名称: | Major capsid protein, Penton protein (VP14), VP137, ... | | 著者 | Zhao, Z.N, Liu, C.C, Zhu, D.J, Qi, J.X, Zhang, X.Z, Gao, G.F. | | 登録日 | 2022-11-20 | | 公開日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.
Nat Commun, 14, 2023
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