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2FL6
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crystal structure of KSP in complex with inhibitor 6
分子名称: (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ...
著者Yan, Y.
登録日2006-01-05
公開日2006-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16, 2006
2FL7
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S. cerevisiae Sir3 BAH domain
分子名称: Regulatory protein SIR3
著者Keck, J.L, Hou, Z, Daner, J.R, Fox, C.A.
登録日2006-01-05
公開日2006-05-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution.
Protein Sci., 15, 2006
2FL8
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Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.
分子名称: Baseplate structural protein Gp10
著者Leiman, P.G, Shneider, M.M, Mesyanzhinov, V.V, Rossmann, M.G.
登録日2006-01-05
公開日2006-04-04
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (12 Å)
主引用文献Evolution of bacteriophage tails: structure of t4 gene product 10
J.Mol.Biol., 358, 2006
2FL9
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Evolution of bacteriophage tails: Structure of T4 gene product 10
分子名称: Baseplate structural protein Gp10
著者Leiman, P.G, Shneider, M.M, Mesyanzhinov, V.V, Rossmann, M.G.
登録日2006-01-05
公開日2006-04-04
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献Evolution of bacteriophage tails: structure of t4 gene product 10
J.Mol.Biol., 358, 2006
2FLA
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Structure of thereduced HiPIP from thermochromatium tepidum at 0.95 angstrom resolution
分子名称: GLYCEROL, High-potential iron-sulfur protein, IRON/SULFUR CLUSTER, ...
著者Hunsicker-Wang, L.M, Stout, C.D, Fee, J.A.
登録日2006-01-05
公開日2006-12-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Geometric factors determine, in part, the electronic state of the 4Fe-4S cluster of HiPIP: a geometric, crystallographic, and theoretical study.
To be Published
2FLB
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Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
分子名称: 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, Coagulation factor VII, Tissue factor
著者Katz, B.A.
登録日2006-01-05
公開日2006-04-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of novel hydroxy pyrazole based factor IXa inhibitor.
Bioorg.Med.Chem.Lett., 16, 2006
2FLC
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Post-Reactive Complex of Restriction Endonuclease HinP1I with Nicked Cognate DNA and Magnesium Ions
分子名称: 5'-D(*CP*CP*AP*G)-3', 5'-D(*CP*CP*AP*GP*CP*GP*CP*TP*GP*G)-3', 5'-D(P*CP*GP*CP*TP*GP*G)-3', ...
著者Horton, J.R.
登録日2006-01-05
公開日2006-02-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion.
Nucleic Acids Res., 34, 2006
2FLD
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I-MsoI Re-Designed for Altered DNA Cleavage Specificity
分子名称: 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ...
著者Ashworth, J, Duarte, C.M, Havranek, J.J, Sussman, D, Monnat, R.J, Stoddard, B.L, Baker, D.
登録日2006-01-05
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Computational redesign of endonuclease DNA binding and cleavage specificity.
Nature, 441, 2006
2FLE
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Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant
分子名称: (2S,2'S)-N,N'-[(2S,3S,4S,5S)-1-CYCLOHEXYL-3,4-DIHYDROXY-6-PHENYLHEXANE-2,5-DIYL]BIS[3-METHYL-2-({[METHYL(PYRIDIN-2-YLMETHYL)AMINO]CARBONYL}AMINO)BUTANAMIDE], GLYCEROL, pol protein
著者Clemente, J.C, Robbins, A, Dunn, B.M, Sussman, F.
登録日2006-01-05
公開日2007-01-16
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
J.Med.Chem., 51, 2008
2FLF
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Crystal structure of l-fuculose-1-phosphate aldolase from Thermus Thermophilus HB8
分子名称: fuculose-1-phosphate aldolase
著者Jeyakanthan, J, Yokoyama, S, Shiro, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-01-06
公開日2007-01-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Purification, crystallization and preliminary X-ray crystallographic study of the L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8
Acta Crystallogr.,Sect.F, 61, 2005
2FLG
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Solution structure of an EGF-LIKE domain from the Plasmodium falciparum merozoite surface protein 1
分子名称: Merozoite surface protein 1
著者James, S, Moehle, K, Pluschke, G, Robinson, J.
登録日2006-01-06
公開日2006-02-21
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from Plasmodium falciparum merozoite surface protein-1.
Chembiochem, 7, 2006
2FLH
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Crystal structure of cytokinin-specific binding protein from mung bean in complex with cytokinin
分子名称: (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, SODIUM ION, cytokinin-specific binding protein
著者Pasternak, O, Bujacz, G.D, Sikorski, M.M, Jaskolski, M.
登録日2006-01-06
公開日2006-11-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structure of Vigna radiata Cytokinin-Specific Binding Protein in Complex with Zeatin.
Plant Cell, 18, 2006
2FLI
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The crystal structure of D-ribulose 5-phosphate 3-epimerase from Streptococus pyogenes complexed with D-xylitol 5-phosphate
分子名称: D-XYLITOL-5-PHOSPHATE, ZINC ION, ribulose-phosphate 3-epimerase
著者Fedorov, A.A, Fedorov, E.V, Akana, J, Gerlt, J.A, Almo, S.C.
登録日2006-01-06
公開日2006-03-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献d-Ribulose 5-Phosphate 3-Epimerase: Functional and Structural Relationships to Members of the Ribulose-Phosphate Binding (beta/alpha)(8)-Barrel Superfamily(,).
Biochemistry, 45, 2006
2FLJ
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Fatty acid binding protein from locust flight muscle in complex with oleate
分子名称: Fatty acid-binding protein, OLEIC ACID
著者Luecke, C, Qiao, Y, van Moerkerk, H.T.B, Veerkamp, J.H, Hamilton, J.A.
登録日2006-01-06
公開日2006-05-23
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Fatty-acid-binding protein from the flight muscle of Locusta migratoria: evolutionary variations in fatty acid binding.
Biochemistry, 45, 2006
2FLK
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Crystal structure of CheY in complex with CheZ(200-214) solved from a F432 crystal grown in CAPS (pH 10.5)
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, C-terminal 15-mer from Chemotaxis protein cheZ, Chemotaxis protein cheY, ...
著者Guhaniyogi, J, Robinson, V.L, Stock, A.M.
登録日2006-01-06
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Beryllium Fluoride-free and Beryllium Fluoride-bound CheY in Complex with the Conserved C-terminal Peptide of CheZ Reveal Dual Binding Modes Specific to CheY Conformation.
J.Mol.Biol., 359, 2006
2FLL
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Ternary complex of human DNA polymerase iota with DNA and dTTP
分子名称: DNA polymerase iota, DNA primer strand, DNA template strand, ...
著者Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2006-01-06
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
2FLM
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Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker)
分子名称: 4'-{6-[4-(2-CARBOXYPHENYLAMINO)-PHENOXY]-HEXYLOXY}-BIPHENYL-4-CARBOXYLIC ACID, Transthyretin
著者Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C.
登録日2006-01-06
公開日2006-02-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
J.Am.Chem.Soc., 125, 2003
2FLN
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binary complex of catalytic core of human DNA polymerase iota with DNA (template A)
分子名称: DNA polymerase iota, DNA primer strand, DNA template strand
著者Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2006-01-06
公開日2006-12-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
2FLO
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Crystal structure of exopolyphosphatase (PPX) from E. coli O157:H7
分子名称: Exopolyphosphatase
著者Rangarajan, E.S, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
登録日2006-01-06
公開日2006-06-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structure of the Exopolyphosphatase (PPX) from Escherichia coli O157:H7 Suggests a Binding Mode for Long Polyphosphate Chains.
J.Mol.Biol., 359, 2006
2FLP
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Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G)
分子名称: DNA polymerase iota, DNA primer strand, DNA template strand
著者Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2006-01-06
公開日2006-12-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
Structure, 14, 2006
2FLQ
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Crystal Structure of Nitric Oxide Synthase from Geobacillus Stearothermophilus (ATCC 12980) complexed with L-arginine
分子名称: ARGININE, Nitric Oxide Synthase, PROTOPORPHYRIN IX CONTAINING FE
著者Sudhamsu, J, Crane, B.R.
登録日2006-01-06
公開日2006-01-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure and Reactivity of a Thermostable Prokaryotic Nitric-oxide Synthase That Forms a Long-lived Oxy-Heme Complex.
J.Biol.Chem., 281, 2006
2FLR
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Novel 5-Azaindole Factor VIIa Inhibitors
分子名称: Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA
著者Riggs, J.R, Hu, H, Kolesnikov, A, Tong, Z, Leahy, E.M, Wesson, K.E, Shrader, W.D, Vijaykumar, D, Wahl, T.A, Sprengeler, P.A, Green, M.J, Yu, C, Katz, B.A, Young, W.B.
登録日2006-01-06
公開日2007-01-23
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Novel 5-azaindole factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2FLS
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Crystal structure of Human Glutaredoxin 2 complexed with glutathione
分子名称: GLUTATHIONE, Glutaredoxin-2
著者Johansson, C, Smee, C, Kavanagh, K.L, Debreczeni, J, von Delft, F, Gileadi, O, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2006-01-06
公開日2006-01-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of Human Glutaredoxin 2 complexed with glutathione
To be Published
2FLT
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The X-ray structure of the cis-3-chloroacrylic acid dehalogenase cis-CaaD inactivated with (R)-Oxirane-2-carboxylate
分子名称: LACTIC ACID, cis-3-chloroacrylic acid dehalogenase
著者de Jong, R.M.
登録日2006-01-06
公開日2006-11-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY AND INACTIVATION BY (R)-OXIRANE-2-CARBOXYLATE.
J.Biol.Chem., 282, 2007
2FLU
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Crystal Structure of the Kelch-Neh2 Complex
分子名称: Kelch-like ECH-associated protein 1, Nrf2
著者Li, X, Lo, J, Beamer, L, Hannink, M.
登録日2006-01-06
公開日2006-08-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006

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