PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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2R7S	Crystal Structure of Rotavirus SA11 VP1 / RNA (UGUGCC) complex 分子名称: PHOSPHATE ION, RNA (5'-R(*UP*GP*UP*GP*CP*C)-3'), RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-10 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R7V	Crystal Structure of Rotavirus SA11 VP1/RNA (GGCUUU) Complex 分子名称: RNA (5'-R(*G*GP*CP*UP*UP*U)-3'), RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-10 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R93	Elongation complex of RNA polymerase II with a hepatitis delta virus-derived RNA stem loop 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Lehmann, E, Brueckner, F, Cramer, P. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Molecular basis of RNA-dependent RNA polymerase II activity. Nature, 450, 2007
2R92	Elongation complex of RNA polymerase II with artificial RdRP scaffold 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Lehmann, E, Brueckner, F, Cramer, P. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Molecular basis of RNA-dependent RNA polymerase II activity. Nature, 450, 2007
2JV6	YF ED3 Protein NMR Structure 分子名称: Envelope protein E 著者 Volk, D.E, Gandham, S.H.A, May, F.J, Anderson, A, Barrett, A.D.T, Gorenstein, D.G. 登録日 2007-09-12 公開日 2008-09-16 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Yellow Fever Virus Envelope Protein Domain III: A Convergence of Structure and Phylogenetics To be Published
2Z9G	Complex structure of SARS-CoV 3C-like protease with PMA 分子名称: 3C-like proteinase, BENZENE, MERCURY (II) ION 著者 Lee, C.C, Wang, A.H. 登録日 2007-09-19 公開日 2007-12-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
2Z9K	Complex structure of SARS-CoV 3C-like protease with JMF1600 分子名称: (dimethylamino)(hydroxy)zinc', 3C-like proteinase, DIMETHYL SULFOXIDE 著者 Lee, C.C, Wang, A.H. 登録日 2007-09-20 公開日 2007-12-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
2Z9J	Complex structure of SARS-CoV 3C-like protease with EPDTC 分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, zinc(II)hydrogensulfide 著者 Lee, C.C, Wang, A.H. 登録日 2007-09-20 公開日 2007-12-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
2JXF	The solution structure of HCV NS4B(40-69) 分子名称: Genome polyprotein 著者 Montserret, R, Penin, F. 登録日 2007-11-19 公開日 2008-11-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B J.Virol., 83, 2009
3BR9	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: (2R)-2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)propanamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2007-12-21 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3BSA	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2007-12-23 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3BSC	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2007-12-23 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA 分子名称: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... 著者 Zamyatkin, D.F, Ng, K.K.S. 登録日 2007-12-26 公開日 2008-01-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BSO	Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA 分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... 著者 Zamyatkin, D.F, Ng, K.K.S. 登録日 2007-12-26 公開日 2008-01-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
2JZE	NMR structure of the domain 527-651 of the SARS-CoV nonstructural protein nsp3, single conformer closest to the mean coordinates of an ensemble of twenty energy minimized conformers 分子名称: Replicase polyprotein 1ab 著者 Chatterjee, A, Johnson, M.A, Serrano, P, Pedrini, B, Joseph, J, Saikatendu, K, Neuman, B, Stevens, R.C, Wilson, I.A, Buchmeier, M.J, Kuhn, P, Wuthrich, K, Joint Center for Structural Genomics (JCSG) 登録日 2008-01-04 公開日 2008-02-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J.Virol., 83, 2009
2JZD	NMR structure of the domain 527-651 of the SARS-CoV nonstructural protein nsp3 分子名称: Replicase polyprotein 1ab 著者 Chatterjee, A, Johnson, M.A, Serrano, P, Pedrini, B, Joseph, J, Saikatendu, K, Neuman, B, Stevens, R.C, Wilson, I.A, Buchmeier, M.J, Kuhn, P, Wuthrich, K, Joint Center for Structural Genomics (JCSG) 登録日 2008-01-04 公開日 2008-02-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J.Virol., 83, 2009
2JZF	NMR Conformer closest to the mean coordinates of the domain 513-651 of the SARS-CoV nonstructural protein nsp3 分子名称: Replicase polyprotein 1ab 著者 Chatterjee, A, Johnson, M.A, Serrano, P, Pedrini, B, Joseph, J, Saikatendu, K, Neuman, B, Stevens, R.C, Wilson, I.A, Buchmeier, M.J, Kuhn, P, Wuthrich, K, Joint Center for Structural Genomics (JCSG) 登録日 2008-01-04 公開日 2008-02-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J.Virol., 83, 2009
2RNK	NMR structure of the domain 513-651 of the SARS-CoV nonstructural protein nsp3 分子名称: Replicase polyprotein 1ab 著者 Chatterjee, A, Johnson, M.A, Serrano, P, Pedrini, B, Joseph, J, Saikatendu, K, Neuman, B.W, Wilson, I.A, Stevens, R.C, Buchmeier, M.J, Kuhn, P, Wuthrich, K, Joint Center for Structural Genomics (JCSG) 登録日 2008-01-11 公開日 2008-02-05 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J.Virol., 83, 2009
3C6D	The pseudo-atomic structure of dengue immature virus 分子名称: Polyprotein, prM 著者 Li, L. 登録日 2008-02-04 公開日 2008-04-08 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (12.5 Å) 主引用文献 The flavivirus precursor membrane-envelope protein complex: structure and maturation Science, 319, 2008
3CDE	Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2008-02-26 公開日 2009-03-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg.Med.Chem.Lett., 18, 2008
3CDU	Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. 登録日 2008-02-27 公開日 2008-07-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008
3CDW	Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. 登録日 2008-02-27 公開日 2008-07-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008
2ZJO	Crystal structure of hepatitis C virus NS3 helicase with a novel inhibitor 分子名称: Genome polyprotein, N-[4-(BIS{4-[(3-SULFOPHENYL)AMINO]PHENYL}METHYLENE)CYCLOHEXA-2,5-DIEN-1-YLIDENE]-4-SULFOBENZENAMINIUM 著者 Liaw, S.H, Chen, S.J, Hu, C.Y, Chi, W.K, Chu, I.D, Hwang, L.H, Chern, J.W, Chen, D.S. 登録日 2008-03-07 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase To be Published
3CJ5	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide, RNA-directed RNA polymerase 著者 Hendle, j. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CJ0	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 分子名称: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008

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