PDB: 1205 件ウェブページステータス検索Chemie searchBIRD

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7MBY	Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7MBX	Human Cholecystokinin 1 receptor (CCK1R) Gs complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (1.95 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
6D26	Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant 分子名称: OLEIC ACID, Prostaglandin D2 receptor 2, Endolysin chimera, ... 著者 Wang, L, Yao, D, Deepak, K, Liu, H, Gong, W, Fan, H, Wei, Z, Zhang, C. 登録日 2018-04-13 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.798 Å) 主引用文献 Structures of the Human PGD2Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Mol. Cell, 72, 2018
7NA7	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: Antibody fragment, CHOLESTEROL, Ghrelin-27, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7NA8	Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist 分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... 著者 Liu, H, Sun, D, Sun, J, Zhang, C. 登録日 2021-06-20 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
7LD3	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
7LD4	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. 登録日 2021-01-12 公開日 2021-09-08 最終更新日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021
6C1R	Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist avacopan 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MALONATE ION, OLEIC ACID, ... 著者 Liu, H, Wang, L, Wei, Z, Zhang, C. 登録日 2018-01-05 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol., 25, 2018
6BQH	Crystal structure of 5-HT2C in complex with ritanserin 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, ... 著者 Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z. 登録日 2017-11-27 公開日 2018-02-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172, 2018
6C1Q	Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727 分子名称: 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, PMX53, Soluble cytochrome b562, ... 著者 Liu, H, Wang, L, Wei, Z, Zhang, C. 登録日 2018-01-05 公開日 2018-05-30 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol., 25, 2018
6D27	Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, OLEIC ACID, ... 著者 Wang, L, Yao, D, Deepak, K, Liu, H, Gong, W, Fan, H, Wei, Z, Zhang, C. 登録日 2018-04-13 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.738 Å) 主引用文献 Structures of the Human PGD2Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Mol. Cell, 72, 2018
7O7F	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist 分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ... 著者 Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S. 登録日 2021-04-13 公開日 2021-06-30 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist. Sci Adv, 7, 2021
6DO1	Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-like peptide S1I8, ... 著者 Wingler, L.M, McMahon, C, Staus, D.P, Lefkowitz, R.J, Kruse, A.C. 登録日 2018-06-08 公開日 2019-01-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell, 176, 2019
6DRZ	Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ... 著者 McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. 登録日 2018-06-13 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.102 Å) 主引用文献 Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
6DRY	Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ... 著者 McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. 登録日 2018-06-13 公開日 2018-08-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.918 Å) 主引用文献 Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
3UON	Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist 分子名称: (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, CHLORIDE ION, Human M2 muscarinic acetylcholine, ... 著者 Haga, K, Kruse, A.C, Asada, H, Yurugi-Kobayashi, T, Shiroishi, M, Zhang, C, Weis, W.I, Okada, T, Kobilka, B.K, Haga, T, Kobayashi, T. 登録日 2011-11-16 公開日 2012-02-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature, 482, 2012
3VW7	Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, Proteinase-activated receptor 1, ... 著者 Zhang, C, Srinivasan, Y, Arlow, D.H, Fung, J.J, Palmer, D, Zheng, Y, Green, H.F, Pandey, A, Dror, R.O, Shaw, D.E, Weis, W.I, Coughlin, S.R, Kobilka, B.K. 登録日 2012-08-07 公開日 2012-12-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-resolution crystal structure of human protease-activated receptor 1 Nature, 492, 2012
3V2W	Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingosine 1-phosphate receptor 1, Lysozyme chimera, ... 著者 Hanson, M.A, Roth, C.B, Jo, E, Griffith, M.T, Scott, F.L, Reinhart, G, Desale, H, Clemons, B, Cahalan, S.M, Schuerer, S.C, Sanna, M.G, Han, G.W, Kuhn, P, Rosen, H, Stevens, R.C, GPCR Network (GPCR) 登録日 2011-12-12 公開日 2012-02-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Crystal structure of a lipid G protein-coupled receptor. Science, 335, 2012
4A4M	Crystal structure of the light-activated constitutively active N2C, M257Y,D282C rhodopsin mutant in complex with a peptide resembling the C-terminus of the Galpha-protein subunit (GaCT) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3, ... 著者 Deupi, X, Edwards, P, Singhal, A, Nickle, B, Oprian, D.D, Schertler, G.F.X, Standfuss, J. 登録日 2011-10-17 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Stabilized G Protein Binding Site in the Structure of Constitutively Active Metarhodopsin-II. Proc.Natl.Acad.Sci.USA, 109, 2012
3V2Y	Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingosine 1-phosphate receptor 1, Lysozyme chimera (E.C.3.2.1.17), ... 著者 Hanson, M.A, Roth, C.B, Jo, E, Griffith, M.T, Scott, F.L, Reinhart, G, Desale, H, Clemons, B, Cahalan, S.M, Schuerer, S.C, Sanna, M.G, Han, G.W, Kuhn, P, Rosen, H, Stevens, R.C, GPCR Network (GPCR) 登録日 2011-12-12 公開日 2012-02-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of a lipid G protein-coupled receptor. Science, 335, 2012
7YMH	Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline 分子名称: Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... 著者 Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. 登録日 2022-07-28 公開日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
7YM8	Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline 分子名称: CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... 著者 Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. 登録日 2022-07-27 公開日 2023-07-05 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
7YXA	XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... 著者 Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. 登録日 2022-02-15 公開日 2022-08-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022
7YU3	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
7YU5	Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Akasaka, H, Shihoya, W, Nureki, O. 登録日 2022-08-16 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022

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