5MZP

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with caffeine at 2.1A resolution

Summary for 5MZP

Entry DOI	10.2210/pdb5mzp/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, CAFFEINE, ... (8 entities in total)
Functional Keywords	g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutations, membrane protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains	1
Total formula weight	57490.71
Authors	Cheng, K.Y.R.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. (deposition date: 2017-02-01, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Cheng, R.K.Y.,Segala, E.,Robertson, N.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Fiez-Vandal, C.,Marshall, F.H.,Cooke, R.M. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure, 25:1275-1285.e4, 2017 Cited by PubMed: 28712806 DOI: 10.1016/j.str.2017.06.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation