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7FBB
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De novo design protein D12 with MBP tag
分子名称: Maltodextrin-binding protein,de novo designed protein D12
著者Bin, H.
登録日2021-07-09
公開日2021-12-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.307 Å)
主引用文献A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
7DMF
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A de novo protein that rigidly extends the structure of tVHS-like domain in tepsin with a new designed domain
分子名称: Designed protein EXTD-3
著者Xu, Y.
登録日2020-12-03
公開日2021-12-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献A backbone-centred energy function of neural networks for protein design.
Nature, 602, 2022
2LN3
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Solution NMR Structure of DE NOVO DESIGNED PROTEIN, IF3-like fold, Northeast Structural Genomics Consortium Target OR135 (CASD target)
分子名称: DE NOVO DESIGNED PROTEIN OR135
著者Liu, G, Koga, R, Koga, N, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
登録日2011-12-15
公開日2012-02-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Principles for designing ideal protein structures.
Nature, 491, 2012
8UMP
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BU of 8ump by Molmil
T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-18
公開日2023-11-15
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UF0
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BU of 8uf0 by Molmil
T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-03
公開日2023-11-15
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.02 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UI2
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BU of 8ui2 by Molmil
T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml28-redesigned-CutA-fold, T33-ml28-redesigned-tandem-BMC-T-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-09
公開日2024-03-06
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UKM
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BU of 8ukm by Molmil
T33-ml30 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml30-redesigned-4-OT-fold, T33-ml30-redesigned-tandem-BMC-T-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-14
公開日2024-03-06
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UMR
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BU of 8umr by Molmil
T33-ml35 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-18
公開日2024-03-06
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (4.42 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UN1
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BU of 8un1 by Molmil
T33-ml23 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms
分子名称: T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold
著者Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-18
公開日2024-03-06
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
8UJA
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BU of 8uja by Molmil
T33-fn10 - Designed Tetrahedral Protein Cage Using Fragment-based Hydrogen Bond Networks
分子名称: T33-fn10: engineered DrsE like sulfur reductase, T33-fn10: engineered enoyl-CoA hydratase/isomerase
著者Meador, K, Sawaya, M.R, Yeates, T.O.
登録日2023-10-11
公開日2024-03-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 2024
4QKR
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BU of 4qkr by Molmil
Crystal Structure of 6xTyr/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22Y/L44Y/L64Y/L85Y/L108Y/L132Y, Primitive Version 2)
分子名称: DE NOVO PROTEIN 6XTYR/PV2, IMIDAZOLE
著者Longo, L.M, Blaber, M, Tenorio, C.A.
登録日2014-06-09
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.746 Å)
主引用文献A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding.
Protein Sci., 24, 2015
2GJF
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BU of 2gjf by Molmil
NMR structure of the computationally designed procarboxypeptidase-A (1AYE) domain
分子名称: DESIGNED PROTEIN
著者Reichow, S.
登録日2006-03-30
公開日2007-01-16
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.
J.Mol.Biol., 366, 2007
4ETK
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BU of 4etk by Molmil
Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186
分子名称: De novo designed serine hydrolase, SODIUM ION
著者Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2012-04-24
公開日2012-06-13
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
2N8W
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BU of 2n8w by Molmil
Solution NMR Structure of Designed Protein DA05R1, Northeast Structural Genomics Consortium (NESG) Target OR690
分子名称: Designed Protein DA05R1
著者Eletsky, A, Federizon, J.F, Xu, X, Pulavarti, S, Jacobs, T.M, Kuhlman, B, Szyperski, T, Northeast Structural Genomics Consortium (NESG)
登録日2015-10-27
公開日2015-11-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Design of structurally distinct proteins using strategies inspired by evolution.
Science, 352, 2016
2N8I
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Solution NMR Structure of Designed Protein DA05, Northeast Structural Genomics Consortium (NESG) Target OR626
分子名称: Designed Protein DA05
著者Xu, X, Eletsky, A, Federizon, J.F, Jacobs, T.M, Kuhlman, B, Szyperski, T, Northeast Structural Genomics Consortium (NESG)
登録日2015-10-15
公開日2016-01-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Design of structurally distinct proteins using strategies inspired by evolution.
Science, 352, 2016
2GJH
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BU of 2gjh by Molmil
NMR Structure of CFr (C-terminal fragment of computationally designed novel-topology protein Top7)
分子名称: DESIGNED PROTEIN
著者Dantas, G.
登録日2006-03-30
公開日2006-10-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Mis-translation of a Computationally Designed Protein Yields an Exceptionally Stable Homodimer: Implications for Protein Engineering and Evolution.
J.Mol.Biol., 362, 2006
5J9F
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BU of 5j9f by Molmil
Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183)
分子名称: GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
著者Wong, J, Deis, S.M, Dann III, C.E.
登録日2016-04-09
公開日2016-08-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
6O35
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BU of 6o35 by Molmil
Crystal structure of a de novo designed octameric helical-bundle protein
分子名称: de novo designed WSHC8
著者Bick, M.J, Xu, C, Sankaran, B, Baker, D.
登録日2019-02-25
公開日2020-03-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Computational design of transmembrane pores.
Nature, 585, 2020
1JM0
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CRYSTAL STRUCTURE OF FOUR-HELIX BUNDLE MODEL
分子名称: DIMETHYL SULFOXIDE, MANGANESE (II) ION, PROTEIN (FOUR-HELIX BUNDLE MODEL)
著者Di Costanzo, L, Geremia, S.
登録日2001-07-17
公開日2002-01-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center.
J.Am.Chem.Soc., 123, 2001
1JMB
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BU of 1jmb by Molmil
CRYSTAL STRUCTURE OF FOUR-HELIX BUNDLE MODEL
分子名称: DIMETHYL SULFOXIDE, MANGANESE (II) ION, PROTEIN (FOUR-HELIX BUNDLE MODEL)
著者Di Costanzo, L, Geremia, S.
登録日2001-07-18
公開日2002-01-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center.
J.Am.Chem.Soc., 123, 2001
6VFK
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BU of 6vfk by Molmil
De novo designed tetrahedral nanoparticle T33_dn10 displaying 4 copies of BG505-SOSIP trimer on the surface
分子名称: BG505-SOSIP-T33_dn10A, T33_dn10B
著者Antanasijevic, A, Ward, A.B.
登録日2020-01-05
公開日2020-07-22
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.25 Å)
主引用文献Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.
Plos Pathog., 16, 2020
5U9U
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BU of 5u9u by Molmil
De Novo Three-stranded Coiled Coil Peptide Containing a Tris-thiolate Site Engineered by D-Cysteine Ligands
分子名称: Apo-(CoilSer L16(DCY))3, CHLORIDE ION, POLYETHYLENE GLYCOL (N=34), ...
著者Ruckthong, L, Stuckey, J.A, Pecoraro, V.L.
登録日2016-12-18
公開日2017-04-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils.
Chemistry, 23, 2017
5NNQ
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BU of 5nnq by Molmil
Aspartate transcarbamoylase from Chaetomium thermophilum CAD-like bound to carbamoyl phosphate
分子名称: GLYCEROL, ctATC
著者Moreno-Morcillo, M, Grande-Garcia, A, Ramon-Maiques, S.
登録日2017-04-10
公開日2017-06-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Structure, 25, 2017
5NNN
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Aspartate transcarbamoylase from Chaetomium thermophilum CAD-like
分子名称: GLYCEROL, ctATC
著者Moreno-Morcillo, M, Grande-Garcia, A, Ramon-Maiques, S.
登録日2017-04-10
公開日2017-06-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Structure, 25, 2017
5HKF
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BU of 5hkf by Molmil
Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Orotate phosphoribosyltransferase
著者Donini, S, Ferraris, D.M, Bolognesi, G, Rizzi, M.
登録日2016-01-14
公開日2017-01-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017

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