6N80

S. aureus ClpP bound to anti-4a

Summary for 6N80

Entry DOI	10.2210/pdb6n80/pdb
Descriptor	ATP-dependent Clp protease proteolytic subunit, N-[(1R)-1-borono-3-methylbutyl]-N~2~-(2-chloro-4-methoxybenzene-1-carbonyl)-L-leucinamide (3 entities in total)
Functional Keywords	clpp, hydrolase
Biological source	Staphylococcus aureus (strain NCTC 8325)
Total number of polymer chains	14
Total formula weight	322285.63
Authors	Lee, R.E.,Griffith, E.C. (deposition date: 2018-11-28, release date: 2019-06-26, Last modification date: 2019-12-18)
Primary citation	Tan, J.,Grouleff, J.J.,Jitkova, Y.,Diaz, D.B.,Griffith, E.C.,Shao, W.,Bogdanchikova, A.F.,Poda, G.,Schimmer, A.D.,Lee, R.E.,Yudin, A.K. De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX. J.Med.Chem., 62:6377-6390, 2019 Cited by PubMed: 31187989 DOI: 10.1021/acs.jmedchem.9b00878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation