Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6N80

S. aureus ClpP bound to anti-4a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008236	molecular_function	serine-type peptidase activity
S	0009368	cellular_component	endopeptidase Clp complex
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue JT7 A 301

Chain	Residue
A	GLY68
A	GLY127
A	HIS142
A	ILE143
A	HOH405
A	GLY69
A	VAL71
A	SER98
A	MET99
A	HIS123
A	GLN124
A	PRO125
A	LEU126

site_id	AC2
Number of Residues	17
Details	binding site for Di-peptide JT7 B 301 and SER B 98

Chain	Residue
B	GLY68
B	GLY69
B	VAL71
B	ALA97
B	MET99
B	GLY100
B	SER101
B	PHE102
B	MET121
B	HIS123
B	GLN124
B	PRO125
B	LEU126
B	GLY127
B	HIS142
B	ILE143
B	HOH406

site_id	AC3
Number of Residues	19
Details	binding site for Di-peptide JT7 C 301 and SER C 98

Chain	Residue
C	GLY68
C	GLY69
C	VAL71
C	ALA97
C	MET99
C	GLY100
C	SER101
C	PHE102
C	MET121
C	HIS123
C	GLN124
C	PRO125
C	LEU126
C	GLY127
C	ALA139
C	HIS142
C	ILE143
C	HOH414
C	HOH484

site_id	AC4
Number of Residues	18
Details	binding site for Di-peptide JT7 D 301 and SER D 98

Chain	Residue
D	GLY68
D	GLY69
D	VAL71
D	ALA97
D	MET99
D	GLY100
D	SER101
D	PHE102
D	MET121
D	HIS123
D	GLN124
D	PRO125
D	LEU126
D	GLY127
D	HIS142
D	ILE143
D	HOH422
D	HOH475

site_id	AC5
Number of Residues	18
Details	binding site for Di-peptide JT7 E 301 and SER E 98

Chain	Residue
E	GLY68
E	GLY69
E	VAL71
E	ALA97
E	MET99
E	GLY100
E	SER101
E	PHE102
E	MET121
E	HIS123
E	GLN124
E	PRO125
E	LEU126
E	GLY127
E	HIS142
E	ILE143
E	HOH429
E	HOH481

site_id	AC6
Number of Residues	17
Details	binding site for Di-peptide JT7 F 301 and SER F 98

Chain	Residue
F	HIS142
F	ILE143
F	HOH407
F	GLY68
F	GLY69
F	VAL71
F	ALA97
F	MET99
F	GLY100
F	SER101
F	PHE102
F	MET121
F	HIS123
F	GLN124
F	PRO125
F	LEU126
F	GLY127

site_id	AC7
Number of Residues	18
Details	binding site for Di-peptide JT7 G 301 and SER G 98

Chain	Residue
G	GLY68
G	GLY69
G	VAL71
G	ALA97
G	MET99
G	GLY100
G	SER101
G	PHE102
G	MET121
G	HIS123
G	GLN124
G	PRO125
G	LEU126
G	GLY127
G	HIS142
G	ILE143
G	HOH413
G	HOH459

site_id	AC8
Number of Residues	19
Details	binding site for Di-peptide JT7 I 301 and SER I 98

Chain	Residue
I	GLY68
I	GLY69
I	VAL71
I	ALA97
I	MET99
I	GLY100
I	SER101
I	PHE102
I	MET121
I	HIS123
I	GLN124
I	PRO125
I	LEU126
I	GLY127
I	ALA139
I	HIS142
I	ILE143
I	HOH410
I	HOH452

site_id	AC9
Number of Residues	18
Details	binding site for Di-peptide JT7 K 301 and SER K 98

Chain	Residue
K	GLY68
K	GLY69
K	VAL71
K	ALA97
K	MET99
K	GLY100
K	SER101
K	PHE102
K	MET121
K	HIS123
K	GLN124
K	PRO125
K	LEU126
K	GLY127
K	HIS142
K	ILE143
K	HOH404
K	HOH481

site_id	AD1
Number of Residues	19
Details	binding site for Di-peptide JT7 L 301 and SER L 98

Chain	Residue
L	GLY68
L	GLY69
L	VAL71
L	ALA97
L	MET99
L	GLY100
L	SER101
L	PHE102
L	MET121
L	HIS123
L	GLN124
L	PRO125
L	LEU126
L	GLY127
L	ALA139
L	HIS142
L	ILE143
L	HOH414
L	HOH508

site_id	AD2
Number of Residues	18
Details	binding site for Di-peptide JT7 M 301 and SER M 98

Chain	Residue
M	GLY68
M	GLY69
M	VAL71
M	ALA97
M	MET99
M	GLY100
M	SER101
M	PHE102
M	MET121
M	HIS123
M	GLN124
M	PRO125
M	LEU126
M	GLY127
M	HIS142
M	ILE143
M	HOH416
M	HOH476

site_id	AD3
Number of Residues	18
Details	binding site for Di-peptide JT7 N 301 and SER N 98

Chain	Residue
N	GLY68
N	GLY69
N	VAL71
N	ALA97
N	MET99
N	GLY100
N	SER101
N	PHE102
N	MET121
N	HIS123
N	GLN124
N	PRO125
N	LEU126
N	GLY127
N	HIS142
N	ILE143
N	HOH406
N	HOH469

site_id	AD4
Number of Residues	17
Details	binding site for Di-peptide JT7 S 301 and SER S 98

Chain	Residue
S	GLY68
S	GLY69
S	VAL71
S	ALA97
S	MET99
S	GLY100
S	SER101
S	PHE102
S	MET121
S	HIS123
S	GLN124
S	PRO125
S	LEU126
S	GLY127
S	HIS142
S	ILE143
S	HOH412

site_id	AD5
Number of Residues	17
Details	binding site for Di-peptide JT7 T 301 and SER T 98

Chain	Residue
T	GLY68
T	GLY69
T	VAL71
T	ALA97
T	MET99
T	GLY100
T	SER101
T	PHE102
T	MET121
T	HIS123
T	GLN124
T	PRO125
T	LEU126
T	GLY127
T	HIS142
T	ILE143
T	HOH404

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicIGmAASMGS

Chain	Residue	Details
A	THR90-SER101

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnaeVMIHQP

Chain	Residue	Details
A	ARG112-PRO125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	SER98
L	SER98
M	SER98
N	SER98
S	SER98
T	SER98
B	SER98
C	SER98
D	SER98
E	SER98
F	SER98
G	SER98
I	SER98
K	SER98

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	HIS123
L	HIS123
M	HIS123
N	HIS123
S	HIS123
T	HIS123
B	HIS123
C	HIS123
D	HIS123
E	HIS123
F	HIS123
G	HIS123
I	HIS123
K	HIS123

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)