PDB: 46054 件ウェブページステータス検索Chemie searchBIRD

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4IE0	Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with pyridine-2,4-dicarboxylate (2,4-PDCA) 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, PYRIDINE-2,4-DICARBOXYLIC ACID, ... 著者 Aik, W.S, McDonough, M.A, Schofield, C.J. 登録日 2012-12-13 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
4IE5	Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(3-hydroxypyridin-2-yl)carbonyl]glycine (MD6) 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO, GLYCEROL, N-[(3-hydroxypyridin-2-yl)carbonyl]glycine, ... 著者 Aik, W.S, McDonough, M.A, Schofield, C.J. 登録日 2012-12-13 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
4NG2	Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa 分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein LasR, Uncharacterized protein 著者 Fan, H, Wu, D.H, Song, H. 登録日 2013-11-01 公開日 2013-12-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.413 Å) 主引用文献 QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing Proc.Natl.Acad.Sci.USA, 110, 2013
4NNJ	Crystal structure of Uba1 in complex with ubiquitin-AMP and thioesterified ubiquitin 分子名称: ADENOSINE MONOPHOSPHATE, GLYCEROL, SULFATE ION, ... 著者 Schaefer, A, Schindelin, H. 登録日 2013-11-18 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules. Acta Crystallogr.,Sect.D, 70, 2014
3CU8	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... 著者 Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. 登録日 2008-04-16 公開日 2009-05-05 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
4NWK	Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide 分子名称: GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ... 著者 Muckelbauer, J.K, Klei, H.E. 登録日 2013-12-06 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
4H0G	Crystal structure of mimicry-recognizing native 2D10 scFv 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2D10 scFv 著者 Tapryal, S, Gaur, V, Kaur, K.J, Salunke, D.M. 登録日 2012-09-08 公開日 2013-06-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural evaluation of a mimicry-recognizing paratope: plasticity in antigen-antibody interactions manifests in molecular mimicry. J.Immunol., 191, 2013
2JHE	N-terminal domain of TyrR transcription factor (residues 1 - 190) 分子名称: 2-(2-ETHOXYETHOXY)ETHANOL, SULFATE ION, TETRAETHYLENE GLYCOL, ... 著者 Verger, D, Carr, P.D, Kwok, T, Ollis, D.L. 登録日 2007-02-21 公開日 2008-06-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of the N-Terminal Domain of the Tyrr Transcription Factor Responsible for Gene Regulation of Aromatic Amino Acid Biosynthesis and Transport in Escherichia Coli K12 J.Mol.Biol., 367, 2007
4P3S	Crystal structure of the bacterial A1408C-mutant ribosomal decoding site in complex with geneticin 分子名称: 5'-R(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3', GENETICIN 著者 Kondo, J, Koganei, M. 登録日 2014-03-10 公開日 2016-05-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the bacterial A1408C-mutant ribosomal decoding site in complex with geneticin To Be Published
4P3T	Crystal structure of the bacterial A1408C-mutant ribosomal decoding site 分子名称: 5'-D(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 著者 Kondo, J, Koganei, M. 登録日 2014-03-10 公開日 2016-05-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the bacterial A1408C-mutant ribosomal decoding site To Be Published
2JV0	SET domain of RIZ1 tumor suppressor (PRDM2) 分子名称: PR domain zinc finger protein 2 著者 Briknarova, K. 登録日 2007-09-10 公開日 2008-01-22 最終更新日 2021-10-20 実験手法 SOLUTION NMR 主引用文献 Structural studies of the SET domain from RIZ1 tumor suppressor Biochem.Biophys.Res.Commun., 366, 2008
3CJW	Crystal structure of the human COUP-TFII ligand binding domain 分子名称: COUP transcription factor 2 著者 Kruse, S.W, Reynolds, R, Vonrhein, C, Xu, H.E. 登録日 2008-03-14 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid-Activated Receptor. Plos Biol., 6, 2008
3B44	Crystal structure of GlpG W136A mutant 分子名称: glpG, nonyl beta-D-glucopyranoside 著者 Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. 登録日 2007-10-23 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
2JZX	PCBP2 KH1-KH2 domains 分子名称: Poly(rC)-binding protein 2 著者 Du, Z, Fenn, S, Tjhen, R, James, T. 登録日 2008-01-21 公開日 2008-08-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of the first and second KH domains of human poly-C binding protein-2 reveals insights into its regulatory mechanisms To be Published
3B84	Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3) 分子名称: 1,2-ETHANEDIOL, UNKNOWN ATOM OR ION, Zinc finger and BTB domain-containing protein 48 著者 Filippakopoulos, P, Bullock, A, Cooper, C, Keates, T, Salah, E, Pilka, E, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2007-10-31 公開日 2007-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal Structure of the Human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3). To be Published
4PDQ	Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog 分子名称: (2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy }-4-[(2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranosyl)oxy]-2-hydroxycyclohexyl}-2-hydroxybutanamide, MAGNESIUM ION, RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3') 著者 Hanessian, S, Saavedra, O.M, Vilchis-Reyes, M.A, Maianti, J.P, Kanazawa, H, Dozzo, P, Feeney, L.A, Armstrong, E.S, Kondo, J. 登録日 2014-04-21 公開日 2015-01-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs Chem Sci, 5, 2014
3BBL	Crystal structure of a regulatory protein of LacI family from Chloroflexus aggregans 分子名称: 1,2-ETHANEDIOL, Regulatory protein of LacI family 著者 Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2007-11-09 公開日 2007-11-27 最終更新日 2021-02-03 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of a regulatory protein of LacI family from the Chloroflexus aggregans. To be Published
2UZ3	Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum 分子名称: MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ... 著者 Welin, M, Kosinska, U, Mikkelsen, N.E, Carnrot, C, Zhu, C, Wang, L, Eriksson, S, Munch-Petersen, B, Eklund, H. 登録日 2007-04-24 公開日 2007-05-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of Thymidine Kinase 1 of Human and Mycoplasmic Origin Proc.Natl.Acad.Sci.USA, 101, 2004
3B7G	Human DEAD-box RNA helicase DDX20, Conserved domain I (DEAD) in complex with AMPPNP (Adenosine-(Beta,gamma)-imidotriphosphate) 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable ATP-dependent RNA helicase DDX20 著者 Karlberg, T, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) 登録日 2007-10-30 公開日 2007-11-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Comparative Structural Analysis of Human DEAD-Box RNA Helicases. Plos One, 5, 2010
3B5R	Crystal structure of the androgen receptor ligand binding domain in complex with SARM C-31 分子名称: (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor 著者 Bohl, C.E, Miller, D.D, Dalton, J.T. 登録日 2007-10-26 公開日 2008-09-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18, 2008
3DT3	Human Estrogen receptor alpha LBD with GW368 分子名称: 5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7-methylnaphthalen-2-ol, Estrogen receptor 著者 Williams, S.P, Miller, A.B. 登録日 2008-07-14 公開日 2008-09-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Bioorg.Med.Chem.Lett., 18, 2008
3EW8	Crystal Structure Analysis of human HDAC8 D101L variant 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, GLYCEROL, ... 著者 Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2008-10-14 公開日 2008-12-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
4IZA	Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 分子名称: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1 著者 Mace, P.D, Robinson, H, Riedl, S.J. 登録日 2013-01-29 公開日 2013-04-10 最終更新日 2013-04-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013
3F0R	Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form 分子名称: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2008-10-25 公開日 2008-12-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
4EQH	Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Trp-AMS 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, Histidine triad nucleotide-binding protein 1 著者 Wang, J, Fang, P, Guo, M. 登録日 2012-04-18 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.668 Å) 主引用文献 Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor. J.Phys.Chem.B, 116, 2012

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