3DT3

Human Estrogen receptor alpha LBD with GW368

Summary for 3DT3

Entry DOI	10.2210/pdb3dt3/pdb
Related	1L2I 1UOM 1X7E 1X7R 2OUZ 3ERT
Descriptor	Estrogen receptor, 5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7-methylnaphthalen-2-ol (3 entities in total)
Functional Keywords	estrogen receptor, nuclear receptor, serm, transcription factor, alpha-helical sandwich, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	2
Total formula weight	58959.39
Authors	Williams, S.P.,Miller, A.B. (deposition date: 2008-07-14, release date: 2008-09-09, Last modification date: 2024-04-03)
Primary citation	Fang, J.,Akwabi-Ameyaw, A.,Britton, J.E.,Katamreddy, S.R.,Navas, F.,Miller, A.B.,Williams, S.P.,Gray, D.W.,Orband-Miller, L.A.,Shearin, J.,Heyer, D. Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Bioorg.Med.Chem.Lett., 18:5075-5077, 2008 Cited by PubMed: 18722117 DOI: 10.1016/j.bmcl.2008.07.121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation