3DT3
Human Estrogen receptor alpha LBD with GW368
Summary for 3DT3
Entry DOI | 10.2210/pdb3dt3/pdb |
Related | 1L2I 1UOM 1X7E 1X7R 2OUZ 3ERT |
Descriptor | Estrogen receptor, 5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7-methylnaphthalen-2-ol (3 entities in total) |
Functional Keywords | estrogen receptor, nuclear receptor, serm, transcription factor, alpha-helical sandwich, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
Total number of polymer chains | 2 |
Total formula weight | 58959.39 |
Authors | Williams, S.P.,Miller, A.B. (deposition date: 2008-07-14, release date: 2008-09-09, Last modification date: 2024-04-03) |
Primary citation | Fang, J.,Akwabi-Ameyaw, A.,Britton, J.E.,Katamreddy, S.R.,Navas, F.,Miller, A.B.,Williams, S.P.,Gray, D.W.,Orband-Miller, L.A.,Shearin, J.,Heyer, D. Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. Bioorg.Med.Chem.Lett., 18:5075-5077, 2008 Cited by PubMed: 18722117DOI: 10.1016/j.bmcl.2008.07.121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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