4N49
 
 | | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, S-ADENOSYLMETHIONINE, ... | | 著者 | Smietanski, M, Werener, M, Purta, E, Kaminska, K.H, Stepinski, J, Darzynkiewicz, E, Nowotny, M, Bujnicki, J.M. | | 登録日 | 2013-10-08 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5, 2014
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2LO2
 | | Solution structure of Sgf11(63-99) zinc finger domain | | 分子名称: | SAGA-associated factor 11, ZINC ION | | 著者 | Gao, X, Koehler, C, Bonnet, J, Devys, D, Kieffer, B. | | 登録日 | 2012-01-10 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Insights into the role of SGF11 and SGF73 for the interaction between SAGA and nucleosomes
To be Published
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8J4Y
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8J4X
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9E1X
 | | Snf2h bound nucleosome complex - ClassD1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (149-MER), DNA (150-MER), ... | | 著者 | Malik, D, Deshmukh, A.A, Bilokapic, S, Halic, M. | | 登録日 | 2024-10-21 | | 公開日 | 2025-01-22 | | 最終更新日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanisms of chromatin remodeling by an Snf2-type ATPase.
Biorxiv, 2025
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4ZUX
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5WA9
 | | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex | | 分子名称: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | | 著者 | Maize, K.M, Finzel, B.C. | | 登録日 | 2017-06-26 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017
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5Z3V
 | | Structure of Snf2-nucleosome complex at shl-2 in ADP BeFx state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | 登録日 | 2018-01-08 | | 公開日 | 2019-05-22 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.22 Å) | | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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1XSA
 | | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) | | 分子名称: | Bis(5'-nucleosyl)-tetraphosphatase | | 著者 | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | | 登録日 | 2004-10-18 | | 公開日 | 2004-12-21 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase
J.Biol.Chem., 280, 2005
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4OQM
 | | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU | | 分子名称: | 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethynylpyrimidine-2,4(1H,3H)-dione, SULFATE ION, Thymidine kinase | | 著者 | Pernot, L, Neef, A.B, Westermaier, Y, Perozzo, R, Luedtke, N, Scapozza, L. | | 登録日 | 2014-02-10 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU
To be Published
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4OQL
 | | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with dF-EdU | | 分子名称: | 2'-deoxy-5-ethynyl-2',2'-difluorouridine, SULFATE ION, Thymidine kinase | | 著者 | Pernot, L, Neef, A.B, Westermaier, Y, Perozzo, R, Luedtke, N, Scapozza, L. | | 登録日 | 2014-02-10 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with dF-EdU
To be Published
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1XSB
 | | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP. No ATP restraints included | | 分子名称: | Bis(5'-nucleosyl)-tetraphosphatase | | 著者 | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | | 登録日 | 2004-10-18 | | 公開日 | 2004-12-21 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase
J.Biol.Chem., 280, 2005
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5WA8
 | | Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside L-Ala phosphoramidate substrate complex | | 分子名称: | CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{S})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid | | 著者 | Maize, K.M, Finzel, B.C. | | 登録日 | 2017-06-26 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017
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5Z3L
 | | Structure of Snf2-nucleosome complex in apo state | | 分子名称: | DNA (167-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | 登録日 | 2018-01-08 | | 公開日 | 2019-04-03 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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1XSC
 | | Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bis(5'-nucleosyl)-tetraphosphatase | | 著者 | Swarbrick, J.D, Buyya, S, Gunawardana, D, Gayler, K.R, McLennan, A.G, Gooley, P.R. | | 登録日 | 2004-10-18 | | 公開日 | 2004-12-21 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase
J.Biol.Chem., 280, 2005
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4OQN
 | | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with EdU | | 分子名称: | 2'-deoxy-5-ethynyluridine, SULFATE ION, Thymidine kinase | | 著者 | Pernot, L, Neef, A.B, Westermaier, Y, Perozzo, R, Luedtke, N.W, Scapozza, L. | | 登録日 | 2014-02-10 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with EdU
To be Published
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4OQX
 | | Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with Me-ARA-EdU | | 分子名称: | 1-(2-deoxy-2-methyl-beta-D-arabinofuranosyl)-5-ethynylpyrimidine-2,4(1H,3H)-dione, SULFATE ION, Thymidine kinase | | 著者 | Pernot, L, Neef, A.B, Westermaier, Y, Perozzo, R, Luedtke, N, Scapozza, L. | | 登録日 | 2014-02-10 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of HSV1-TK complexed with Me-ARA-EdU
To be Published
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5Z3O
 | | Structure of Snf2-nucleosome complex in ADP state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (167-MER), Histone H2A, ... | | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | 登録日 | 2018-01-08 | | 公開日 | 2019-04-03 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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5Z3U
 | | Structure of Snf2-nucleosome complex at shl2 in ADP BeFx state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | 登録日 | 2018-01-08 | | 公開日 | 2019-05-22 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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5VQS
 | | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (JLJ685), a Non-nucleoside Inhibitor | | 分子名称: | N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)prop-2-enamide, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | | 著者 | Chan, A.H, Anderson, K.S. | | 登録日 | 2017-05-09 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | | 主引用文献 | Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5VQV
 | | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor | | 分子名称: | N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylpropanamide, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | | 著者 | Chan, A.H, Anderson, K.S. | | 登録日 | 2017-05-09 | | 公開日 | 2017-08-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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9E1U
 | | Snf2h bound nucleosome complex - ClassC1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (151-MER), DNA (152-MER), ... | | 著者 | Malik, D, Deshmukh, A.A, Bilokapic, S, Halic, M. | | 登録日 | 2024-10-21 | | 公開日 | 2025-01-22 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanisms of chromatin remodeling by an Snf2-type ATPase.
Biorxiv, 2025
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5VQT
 | | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor | | 分子名称: | 2-chloro-N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylacetamide, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | | 著者 | Chan, A.H, Czyzyk, D.J, Anderson, K.S. | | 登録日 | 2017-05-09 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.556 Å) | | 主引用文献 | Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5VQX
 | | Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 2-chloro-N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacetamide (JLJ686), a Non-nucleoside Inhibitor | | 分子名称: | N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylacetamide, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | | 著者 | Chan, A.H, Anderson, K.S. | | 登録日 | 2017-05-09 | | 公開日 | 2017-08-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7P08
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