4N49

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM

Summary for 4N49

Related4N48 4N4A
DescriptorCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, S-ADENOSYLMETHIONINE, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsmethyltransferase, mrna cap methylation, mrna, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus  Q8N1G2
Total number of polymer chains1
Total molecular weight49896.4
Authors
Smietanski, M.,Werener, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M. (deposition date: 2013-10-08, release date: 2014-01-22, Last modification date: 2017-11-15)
Primary citation
Smietanski, M.,Werner, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M.
Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Nat Commun, 5:3004-3004, 2014
PubMed: 24402442 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms4004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20320.3%3.7%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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