4N49
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE SAM A 601 |
| Chain | Residue |
| A | ASN234 |
| A | THR301 |
| A | LEU302 |
| A | ASN306 |
| A | GLY334 |
| A | ASP335 |
| A | ILE336 |
| A | ASP364 |
| A | GLY366 |
| A | LEU383 |
| A | HOH758 |
| A | ALA236 |
| A | HOH887 |
| A | HOH1103 |
| A | HOH1174 |
| A | CYS277 |
| A | ALA278 |
| A | GLY279 |
| A | PRO280 |
| A | GLY281 |
| A | GLY282 |
| A | PHE283 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE MGT A 602 |
| Chain | Residue |
| A | LYS203 |
| A | SER204 |
| A | PHE206 |
| A | ASP207 |
| A | MET214 |
| A | ARG218 |
| A | GLU373 |
| A | ASN374 |
| A | ALA438 |
| A | ASN439 |
| A | HOH759 |
| A | HOH822 |
| A | HOH865 |
| A | HOH878 |
| A | HOH928 |
| A | HOH954 |
| A | HOH955 |
| A | HOH1035 |
| A | HOH1076 |
| A | HOH1101 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 603 |
| Chain | Residue |
| A | ARG235 |
| A | LYS239 |
| A | ARG436 |
| A | ASN439 |
| A | GLU441 |
| A | HOH1035 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"21310715","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21310715","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24402442","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N49","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
