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4N49

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM

Functional Information from GO Data
ChainGOidnamespacecontents
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE SAM A 601
ChainResidue
AASN234
ATHR301
ALEU302
AASN306
AGLY334
AASP335
AILE336
AASP364
AGLY366
ALEU383
AHOH758
AALA236
AHOH887
AHOH1103
AHOH1174
ACYS277
AALA278
AGLY279
APRO280
AGLY281
AGLY282
APHE283

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE MGT A 602
ChainResidue
ALYS203
ASER204
APHE206
AASP207
AMET214
AARG218
AGLU373
AASN374
AALA438
AASN439
AHOH759
AHOH822
AHOH865
AHOH878
AHOH928
AHOH954
AHOH955
AHOH1035
AHOH1076
AHOH1101

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 603
ChainResidue
AARG235
ALYS239
AARG436
AASN439
AGLU441
AHOH1035

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:21310715
ChainResidueDetails
ALYS239
AASP364

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000305|PubMed:21310715
ChainResidueDetails
ALYS404

site_idSWS_FT_FI3
Number of Residues7
DetailsBINDING: BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
ChainResidueDetails
ALYS203
AARG218
AASN234
ACYS277
AASP335
AASN374
AASN439

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PDB entries from 2024-11-06

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