PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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8EP8	Engineering Crystals with Tunable Symmetries from 14- or 16-Base-Long DNA Strands 分子名称: DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*GP*A)-3'), DNA (5'-D(P*TP*CP*CP*GP*C)-3') 著者 Zhang, C, Zhao, J, Lu, B, Sha, R, Seeman, N.C, Noinaj, N, Mao, C. 登録日 2022-10-05 公開日 2023-03-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Engineering DNA Crystals toward Studying DNA-Guest Molecule Interactions. J.Am.Chem.Soc., 145, 2023
4TT7	Crystal structure of human ALK with a covalent modification 分子名称: 1,2-ETHANEDIOL, 1-THIOETHANESULFONIC ACID, ALK tyrosine kinase receptor 著者 Badger, J, Sridhar, V, Chie-Leon, B, Nienaber, V.L, Hausheer, F.H. 登録日 2014-06-19 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787. Onco Targets Ther, 8, 2015
3K3Q	Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain 分子名称: Botulinum neurotoxin type A, ZINC ION, llama Aa1 VHH domain 著者 Thompson, A.A, Dong, J, Marks, J.D, Stevens, R.C. 登録日 2009-10-04 公開日 2010-02-23 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region. J.Mol.Biol., 397, 2010
6O4G	Structure of ALDH7A1 mutant P169S complexed with alpha-aminoadipate 分子名称: 2-AMINOHEXANEDIOIC ACID, Alpha-aminoadipic semialdehyde dehydrogenase 著者 Tanner, J.J, Korasick, D.A, Laciak, A.R. 登録日 2019-02-28 公開日 2019-07-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1. Febs J., 287, 2020
8PBG	Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBP	Mutant R1785C of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBE	Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBI	Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBM	Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the substrate dihydroorotate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBQ	Mutant R1810Q of the dihydroorotase domain of human CAD protein bound to the substrates 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBR	Mutant R1475Q of the dihydroorotase domain of human CAD protein in apo form 分子名称: CAD protein, FORMIC ACID, ZINC ION 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBJ	Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: CAD protein, FORMIC ACID, GLYCEROL, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBN	Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBT	Mutant K1482M of the dihydroorotase domain of human CAD protein bound to the substrate dihydroorotate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBU	Mutant K1482M of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBH	Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBK	Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBS	Mutant K1482M of the dihydroorotase domain of human CAD protein in apo form 分子名称: CAD protein, FORMIC ACID, GLYCEROL, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8J2F	Human neutral shpingomyelinase 分子名称: HEPTANE, MAGNESIUM ION, Sphingomyelin phosphodiesterase 2, ... 著者 Zhang, S.S. 登録日 2023-04-14 公開日 2023-12-06 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2). Nat Commun, 14, 2023
8I7J	Yeast 40S-eIF4B - partially open conformation of the 40S head 分子名称: 40S ribosomal protein S0, 40S ribosomal protein S1, 40S ribosomal protein S12, ... 著者 Datey, A, Khaja, F.T, Hussain, T. 登録日 2023-01-31 公開日 2024-02-07 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Yeast eukaryotic initiation factor 4B remodels the mRNA entry site on the small ribosomal subunit To Be Published
3K7F	Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase' 分子名称: 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, Fatty-acid amide hydrolase 1, ... 著者 Mileni, M, Stevens, R.C, Boger, D.L. 登録日 2009-10-13 公開日 2009-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53, 2010
8CXP	Characterisation of a Seneca Valley Virus Thermostable Mutant 分子名称: Capsid protein VP1, Capsid protein VP3, VP2, ... 著者 Jayawardena, N, Bostina, M, Strauss, M. 登録日 2022-05-22 公開日 2022-09-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.47 Å) 主引用文献 Characterisation of a Seneca Valley virus thermostable mutant. Virology, 575, 2022
8P1I	Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution 分子名称: 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL), 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline, Efflux pump membrane transporter, ... 著者 Boernsen, C, Mueller, R.T, Pos, K.M, Frangakis, A.S. 登録日 2023-05-12 公開日 2024-01-17 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae. Embo Mol Med, 16, 2024
3HQT	PLP-Dependent Acyl-CoA Transferase CqsA 分子名称: CAI-1 autoinducer synthase, PYRIDOXAL-5'-PHOSPHATE 著者 Kelly, R.C, Jeffrey, P.D, Hughson, F.M. 登録日 2009-06-08 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
6NE8	Solution Structure of the Thioredoxin-like Domain of Arabidopsis NCP (NUCLEAR CONTROL OF PEP ACTIVITY) 分子名称: Thioredoxin-like fold domain-containing protein MRL7L, chloroplastic 著者 Liu, J, Chen, M, Zhou, P. 登録日 2018-12-17 公開日 2019-12-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nat Commun, 10, 2019

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