PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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4E8A	The crystal structure of p38a MAP kinase in complex with PIA24 分子名称: (1R,2S,3R,4S,6S)-6-(cyclohexylmethoxy)-2,3,4-trihydroxycyclohexyl (2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 著者 Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. 登録日 2012-03-20 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
4E5A	The W197A mutant of p38a MAP kinase 分子名称: Mitogen-activated protein kinase 14 著者 Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. 登録日 2012-03-14 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
5WOZ	NMR solution structure of Rtt103 (RTT) protein using two 4D-spectra 分子名称: Regulator of Ty1 transposition protein 103 著者 Evangelidis, T, Nerli, S, Sgourakis, N.G, Tripsianes, K. 登録日 2017-08-03 公開日 2018-02-07 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Automated NMR resonance assignments and structure determination using a minimal set of 4D spectra. Nat Commun, 9, 2018
8PEO	H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Veverka, V. 登録日 2023-06-14 公開日 2023-08-16 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (2.69 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
8PC5	H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Veverka, V. 登録日 2023-06-09 公開日 2023-08-16 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
8PC6	H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Veverka, V. 登録日 2023-06-09 公開日 2023-08-16 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
6QTJ	Crystal structure of human CDK8/CYCC in complex with BI 919811 分子名称: Cyclin-C, Cyclin-dependent kinase 8, ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide 著者 Boettcher, J. 登録日 2019-02-25 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
4MK1	5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease 分子名称: 1,2-ETHANEDIOL, 5-bromo-3-hydroxypyridin-2(1H)-one, MANGANESE (II) ION, ... 著者 Bauman, J.D, Patel, D, Das, K, Arnold, E. 登録日 2013-09-04 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
4HRG	Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with AHNAK1 Peptide 分子名称: Neuroblast differentiation-associated protein AHNAK, Protein S100-A10 著者 Gao, P, Patel, D.J. 登録日 2012-10-27 公開日 2013-03-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.0001 Å) 主引用文献 SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.), 152, 2013
6R3S	CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 分子名称: 1,2-ETHANEDIOL, 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide, Cyclin-C, ... 著者 Boettcher, J. 登録日 2019-03-21 公開日 2020-04-08 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
3FQG	Crystal Structure of the S. pombe Rai1 分子名称: MAGNESIUM ION, Protein din1 著者 Xiang, S, Tong, L. 登録日 2009-01-07 公開日 2009-02-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
3FQD	Crystal Structure of the S. pombe Rat1-Rai1 Complex 分子名称: 5'-3' exoribonuclease 2, GLYCEROL, MAGNESIUM ION, ... 著者 Xiang, S, Tong, L. 登録日 2009-01-07 公開日 2009-02-03 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
6QTG	Crystal structure of human CDK8/CYCC in complex with BI-1347 分子名称: 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, Cyclin-C, Cyclin-dependent kinase 8 著者 Boettcher, J. 登録日 2019-02-25 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
6SIS	Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB 分子名称: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... 著者 Hughes, S.J, Testa, A, Ciulli, A. 登録日 2019-08-10 公開日 2019-12-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
6H7X	First X-ray structure of full-length human RuvB-Like 2. 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... 著者 Silva, S, Brito, J.A, Matias, P, Bandeiras, T. 登録日 2018-07-31 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.892 Å) 主引用文献 X-ray structure of full-length human RuvB-Like 2 - mechanistic insights into coupling between ATP binding and mechanical action. Sci Rep, 8, 2018
8OSL	Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) 分子名称: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... 著者 Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. 登録日 2023-04-19 公開日 2023-05-24 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSK	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) 分子名称: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... 著者 Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. 登録日 2023-04-19 公開日 2023-05-24 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSJ	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) 分子名称: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... 著者 Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. 登録日 2023-04-19 公開日 2023-05-24 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
4MK2	3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease 分子名称: 1,2-ETHANEDIOL, 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile, MANGANESE (II) ION, ... 著者 Bauman, J.D, Patel, D, Das, K, Arnold, E. 登録日 2013-09-04 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chem.Biol., 8, 2013
5M2N	Crystal Structure of Elongator subunit Elp2 分子名称: Elongator complex protein 2 著者 Glatt, S, Mueller, C.W. 登録日 2016-10-13 公開日 2016-12-28 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.812 Å) 主引用文献 Architecture of the yeast Elongator complex. EMBO Rep., 18, 2017
8PEP	H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 分子名称: Histone H2A, Histone H2B 1.1, Histone H3, ... 著者 Koutna, E, Kouba, T, Veverka, V. 登録日 2023-06-14 公開日 2023-08-16 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
4WW5	Crystal structure of binary complex Bud32-Cgi121 in complex with AMPP 分子名称: ACETATE ION, EKC/KEOPS complex subunit BUD32, EKC/KEOPS complex subunit CGI121, ... 著者 Zhang, W. 登録日 2014-11-10 公開日 2015-03-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res., 43, 2015
4WW9	Crystal structure of binary complex Bud32-Cgi121 in complex with ADP 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, EKC/KEOPS complex subunit BUD32, ... 著者 Zhang, W, Van Tilbeurgh, H. 登録日 2014-11-10 公開日 2015-03-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res., 43, 2015
2BAK	p38alpha MAP kinase bound to MPAQ 分子名称: Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE 著者 Gerhardt, S, Breed, J, Pauptit, R.A, Read, J, Norman, R.A, Ward, W.H. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005
2BAL	p38alpha MAP kinase bound to pyrazoloamine 分子名称: Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE 著者 Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J. 登録日 2005-10-14 公開日 2005-12-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005

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