4OLD
| Crystal structure of AmpC beta-lactamase in complex with the product form of (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 分子名称: | (2R)-2-[(R)-amino(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Shoichet, B.K, Barelier, S. | 登録日 | 2014-01-23 | 公開日 | 2014-05-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014
|
|
4OOY
| Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Lahiri, S.D, Olivier, N.B, Alm, R.A. | 登録日 | 2014-02-04 | 公開日 | 2014-08-20 | 最終更新日 | 2018-02-14 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Avibactam and Class C beta-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance. Antimicrob.Agents Chemother., 58, 2014
|
|
2ZM8
| Structure of 6-Aminohexanoate-dimer Hydrolase, S112A/D370Y Mutant Complexed with 6-Aminohexanoate-dimer | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Negoro, S. | 登録日 | 2008-04-14 | 公開日 | 2009-04-14 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci., 18, 2009
|
|
2ZMA
| Crystal Structure of 6-Aminohexanoate-dimer Hydrolase S112A/G181D/H266N/D370Y Mutant with Substrate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. | 登録日 | 2008-04-14 | 公開日 | 2009-04-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold Febs J., 276, 2009
|
|
2ZC7
| |
2ZM7
| Structure of 6-Aminohexanoate-dimer Hydrolase, S112A/G181D Mutant Complexed with 6-Aminohexanoate-dimer | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Negoro, S. | 登録日 | 2008-04-14 | 公開日 | 2009-04-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold Febs J., 276, 2009
|
|
2ZM0
| Structure of 6-aminohexanoate-dimer hydrolase, G181D/H266N/D370Y mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Nego, S. | 登録日 | 2008-04-10 | 公開日 | 2009-04-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold. Febs J., 276, 2009
|
|
2ZM2
| Structure of 6-aminohexanoate-dimer hydrolase, A61V/A124V/R187S/F264C/G291R/G338A/D370Y mutant (Hyb-S4M94) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Nego, S. | 登録日 | 2008-04-10 | 公開日 | 2009-04-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci., 18, 2009
|
|
4QD4
| Structure of ADC-68, a Novel Carbapenem-Hydrolyzing Class C Extended-Spectrum -Lactamase from Acinetobacter baumannii | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase ADC-68, CITRIC ACID | 著者 | Hong, M.K, Kang, L.W. | 登録日 | 2014-05-13 | 公開日 | 2015-01-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum beta-lactamase isolated from Acinetobacter baumannii Acta Crystallogr.,Sect.D, 70, 2014
|
|
2Y91
| Crystal structure of class A beta-lactamase from Bacillus licheniformis BS3 with clavulanic acid | 分子名称: | 5-HYDROXY-3-OXOPENTANOIC ACID, BETA-LACTAMASE, CITRIC ACID, ... | 著者 | Power, P, Sauvage, E, Herman, R, Kerff, F, Charlier, P. | 登録日 | 2011-02-11 | 公開日 | 2012-02-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Novel Fragments of Clavulanate Observed in the Structure of the Class a Beta-Lactamase from Bacillus Licheniformis Bs3. J.Antimicrob.Chemother., 67, 2012
|
|
4OLG
| Crystal structure of AmpC beta-lactamase in complex with covalently bound N-formyl 7-aminocephalosporanic acid | 分子名称: | (2R,5Z)-5-[(acetyloxy)methylidene]-2-[(1R)-1-(formylamino)-2-oxoethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Shoichet, B.K, Barelier, S. | 登録日 | 2014-01-23 | 公開日 | 2014-05-28 | 最終更新日 | 2014-06-18 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014
|
|
2ZJ9
| X-ray crystal structure of AmpC beta-Lactamase (AmpC(D)) from an Escherichia coli with a Tripeptide Deletion (Gly286 Ser287 Asp288) on the H10 Helix | 分子名称: | AmpC, ISOPROPYL ALCOHOL, SODIUM ION | 著者 | Yamaguchi, Y, Sato, G, Yamagata, Y, Wachino, J, Arakawa, Y, Kurosaki, H. | 登録日 | 2008-02-29 | 公開日 | 2009-03-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of AmpC beta-lactamase (AmpCD) from an Escherichia coli clinical isolate with a tripeptide deletion (Gly286-Ser287-Asp288) in the H10 helix Acta Crystallogr.,Sect.F, 65, 2009
|
|
2ZLY
| Structure of 6-aminohexanoate-dimer hydrolase, D370Y mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Negoro, S. | 登録日 | 2008-04-10 | 公開日 | 2009-04-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci., 18, 2009
|
|
2ZM9
| Structure of 6-Aminohexanoate-dimer Hydrolase, A61V/S112A/A124V/R187S/F264C/G291R/G338A/D370Y mutant (Hyb-S4M94) with Substrate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Ohki, T, Shibata, N, Higuchi, Y, Kawashima, Y, Takeo, M, Kato, D, Negoro, S. | 登録日 | 2008-04-14 | 公開日 | 2009-04-14 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Two alternative modes for optimizing nylon-6 byproduct hydrolytic activity from a carboxylesterase with a beta-lactamase fold: X-ray crystallographic analysis of directly evolved 6-aminohexanoate-dimer hydrolase. Protein Sci., 18, 2009
|
|
3A66
| Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N/D370Y mutant with substrate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOATE-DIMER HYDROLASE, 6-AMINOHEXANOIC ACID, ... | 著者 | Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. | 登録日 | 2009-08-21 | 公開日 | 2010-09-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
|
|
3A65
| Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N mutant with substrate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. | 登録日 | 2009-08-21 | 公開日 | 2010-09-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
|
|
3B3X
| Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate | 分子名称: | 2-(carboxymethyl)-D-aspartic acid, Beta-lactamase | 著者 | Sauvage, E, Herman, R, Kerff, F, Charlier, P. | 登録日 | 2007-10-23 | 公開日 | 2007-11-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis Bioorg.Med.Chem.Lett., 18, 2008
|
|
3BLS
| AMPC BETA-LACTAMASE FROM ESCHERICHIA COLI | 分子名称: | AMPC BETA-LACTAMASE, M-AMINOPHENYLBORONIC ACID | 著者 | Usher, K.C, Shoichet, B.K, Remington, S.J. | 登録日 | 1998-06-04 | 公開日 | 1998-08-12 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design. Biochemistry, 37, 1998
|
|
3BM6
| AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid | 分子名称: | 4-(dihydroxyboranyl)-2-({[4-(phenylsulfonyl)thiophen-2-yl]sulfonyl}amino)benzoic acid, Beta-lactamase | 著者 | Tondi, D. | 登録日 | 2007-12-12 | 公開日 | 2009-02-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
|
|
4IVI
| Crystal structure of a family VIII carboxylesterase. | 分子名称: | Carboxylesterase, SULFATE ION | 著者 | An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S. | 登録日 | 2013-01-23 | 公開日 | 2013-06-19 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase. Proteins, 81, 2013
|
|
4JXG
| Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Oxacillin | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Beta-lactamase, PHOSPHATE ION, ... | 著者 | Wallar, B.J, Powers, R.A, Docter, B.E. | 登録日 | 2013-03-28 | 公開日 | 2014-10-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Complexed structures of AmpC beta-lactamase To be Published
|
|
4JXV
| |
4KG6
| |
4KZB
| Crystal structure of AmpC beta-lactamase in complex with fragment 50 (N-(methylsulfonyl)-N-phenyl-alanine) | 分子名称: | Beta-lactamase, N-(methylsulfonyl)-N-phenyl-D-alanine, N-(methylsulfonyl)-N-phenyl-L-alanine | 著者 | Eidam, O, Barelier, S, Fish, I, Shoichet, B.K. | 登録日 | 2013-05-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9, 2014
|
|
4KZ4
| Crystal structure of AmpC beta-lactamase in complex with fragment 60 (2-[(propylsulfonyl)amino]benzoic acid) | 分子名称: | 2-[(propylsulfonyl)amino]benzoic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Eidam, O, Barelier, S, Fish, I, Shoichet, B.K. | 登録日 | 2013-05-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9, 2014
|
|