PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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7CL9	Androstenedione-bound structure of CYP154C2 from Streptomyces avermitilis in an open conformation 分子名称: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, ... 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Androstenedione-bound structure of CYP154C2 from Streptomyces avermitilis in an open conformation To Be Published
7CL8	Testosterone-bound structure of CYP154C2 from Streptomyces avermitilis in an closed conformation 分子名称: Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Improved 2 alpha-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design. Appl.Environ.Microbiol., 89, 2023
7CL7	Substrate-free structure of CYP154C2 from Streptomyces avermitilis in an open conformation 分子名称: Cytochrome P450 hydroxylase, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE 著者 Xu, L.H, Fushinobu, S. 登録日 2020-07-20 公開日 2021-07-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Substrate-free structure of CYP154C2 in an open conformation To Be Published
7CKN	Structure of the CYP102A1 Haem Domain with N-{2-[4-(Trifluoromethoxy)phenoxy]}acetoyl-L-Phenylalanine in complex with Isopropylamine 分子名称: (2S)-3-phenyl-2-[2-[4-(trifluoromethyloxy)phenoxy]ethanoylamino]propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2020-07-17 公開日 2021-09-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-{2-[4-(Trifluoromethoxy)phenoxy]}acetoyl-L-Phenylalanine in complex with Isopropylamine at 1.55 Angstrom Resolution To Be Published
7CCF	Mechanism insights on steroselective oxidation of phosphorylated ethylphenols with cytochrome P450 CreJ 分子名称: (3-ethylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Dong, S, Du, L, Li, S.Y, Feng, Y.G. 登録日 2020-06-17 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for Selective Oxidation of Phosphorylated Ethylphenols by Cytochrome P450 Monooxygenase CreJ. Appl.Environ.Microbiol., 87, 2021
7CB9	CYP76AH1/miltiradiene from Salvia miltiorrhiza 分子名称: Ferruginol synthase, Miltiradiene, PROTOPORPHYRIN IX CONTAINING FE 著者 Chang, Z, Chao, S, Mingyue, G. 登録日 2020-06-11 公開日 2021-06-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 CYP76AH1 from Salvia miltiorrhiza To Be Published
7AYX	Structure of the cytochrome P450 AryC from Streptomyces roseosporus NRRL 15998 分子名称: Cytochrome P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Schneider, S, Schaefers, F, Gulder, T.A.M. 登録日 2020-11-13 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Carrier Protein-Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC. Chemistry, 28, 2022
7AO7	Structure of CYP153A from Polaromonas sp. in complex with octan-1-ol 分子名称: Cytochrome P450, OCTAN-1-OL, PROTOPORPHYRIN IX CONTAINING FE 著者 Zukic, E, Rowlinson, B, Sharma, M, Hoffmann, S, Hauer, B, Grogan, G. 登録日 2020-10-13 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
7ANT	Structure of CYP153A from Polaromonas sp. 分子名称: 1,2-ETHANEDIOL, Cytochrome P450, HEME C 著者 Zukic, E, Rowlinson, B, Sharma, M, Hoffman, S, Hauer, B, Grogan, G. 登録日 2020-10-12 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
6ZI7	Crystal structure of OleP-oleandolide(DEO) bound to L-rhamnose 分子名称: (3~{R},4~{S},5~{R},6~{S},7~{S},9~{S},11~{R},12~{S},13~{R},14~{R})-3,5,7,9,11,13,14-heptamethyl-4,6,12-tris(oxidanyl)-1-oxacyclotetradecane-2,10-dione, Cytochrome P-450, FORMIC ACID, ... 著者 Montemiglio, L.C, Savino, C, Vallone, B, Parisi, G, Freda, I. 登録日 2020-06-25 公開日 2020-10-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate. Biomolecules, 10, 2020
6ZI3	Crystal structure of OleP-6DEB bound to L-rhamnose 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, ... 著者 Montemiglio, L.C, Savino, C, Vallone, B, Parisi, G, Freda, I. 登録日 2020-06-24 公開日 2020-10-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate. Biomolecules, 10, 2020
6ZI2	OleP-oleandolide(DEO) in low salt crystallization conditions 分子名称: (3~{R},4~{S},5~{R},6~{S},7~{S},9~{S},11~{R},12~{S},13~{R},14~{R})-3,5,7,9,11,13,14-heptamethyl-4,6,12-tris(oxidanyl)-1-oxacyclotetradecane-2,10-dione, Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE 著者 Savino, C, Montemiglio, L.C, Vallone, B, Parisi, G, Cecchetti, C. 登録日 2020-06-24 公開日 2020-10-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate. Biomolecules, 10, 2020
6ZHZ	OleP-oleandolide(DEO) in high salt crystallization conditions 分子名称: (3~{R},4~{S},5~{R},6~{S},7~{S},9~{S},11~{R},12~{S},13~{R},14~{R})-3,5,7,9,11,13,14-heptamethyl-4,6,12-tris(oxidanyl)-1-oxacyclotetradecane-2,10-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytochrome P-450, ... 著者 Montemiglio, L.C, Savino, C, Vallone, B, Parisi, G, Cecchetti, C. 登録日 2020-06-24 公開日 2020-10-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate. Biomolecules, 10, 2020
6YCT	Crystal structure of GcoA F169A_T296S bound to p-vanillin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-hydroxy-3-methoxybenzaldehyde, Cytochrome P450, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-19 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCP	Crystal structure of GcoA F169V bound to o-vanillin 分子名称: 2-(hydroxymethyl)-6-methoxy-phenol, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCO	Crystal structure of GcoA F169S bound to o-vanillin 分子名称: 2-(hydroxymethyl)-6-methoxy-phenol, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCN	Crystal structure of GcoA F169A bound to o-vanillin 分子名称: 2-(hydroxymethyl)-6-methoxy-phenol, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCM	Crystal structure of GcoA T296S bound to p-vanillin 分子名称: 4-hydroxy-3-methoxybenzaldehyde, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Mallinson, S.J.B, Hinchen, D.J, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCL	Crystal structure of GcoA T296G bound to p-vanillin 分子名称: 4-hydroxy-3-methoxybenzaldehyde, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCK	Crystal structure of GcoA T296A bound to p-vanillin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-hydroxy-3-methoxybenzaldehyde, Aromatic O-demethylase, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCJ	Crystal structure of GcoA T296S bound to guaiacol 分子名称: Aromatic O-demethylase, cytochrome P450 subunit, Guaiacol, ... 著者 Mallinson, S.J.B, Hinchen, D.J, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCI	Crystal structure of GcoA T296G bound to guaiacol 分子名称: Aromatic O-demethylase, cytochrome P450 subunit, Guaiacol, ... 著者 Hinchen, D.J, Mallinson, S.J.B, Allen, M.D, Ellis, E.S, Beckham, G.T, DuBois, J.L, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6YCH	Crystal structure of GcoA T296A bound to guaiacol 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Aromatic O-demethylase, cytochrome P450 subunit, ... 著者 Mallinson, S.J.B, Hinchen, D.J, Ellis, E.S, DuBois, J.L, Beckham, G.T, McGeehan, J.E. 登録日 2020-03-18 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes. Jacs Au, 1, 2021
6XZ9	Structure of aldosterone synthase (CYP11B2) in complex with 5-chloro-3,3-dimethyl-2-[5-[1-(1-methylpyrazole-4-carbonyl)azetidin-3-yl]oxy-3-pyridyl]isoindolin-1-one 分子名称: 5-chloranyl-3,3-dimethyl-2-[5-[1-(1-methylpyrazol-4-yl)carbonylazetidin-3-yl]oxypyridin-3-yl]isoindol-1-one, Cytochrome P450 11B2, mitochondrial, ... 著者 Kuglstatter, A, Joseph, C, Benz, J. 登録日 2020-02-03 公開日 2020-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020
6XZ8	Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide 分子名称: Cytochrome P450 11B2, mitochondrial, HEME C, ... 著者 Kuglstatter, A, Joseph, C, Benz, J. 登録日 2020-02-03 公開日 2020-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. J.Med.Chem., 63, 2020

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