PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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1PDU	Ligand-binding domain of Drosophila orphan nuclear receptor DHR38 分子名称: nuclear hormone receptor HR38 著者 Baker, K.D, Shewchuk, L.M, Korlova, T, Makishima, M, Hassell, A.M, Wisely, B, Caravella, J.A, Lambert, M.H, Wilson, T.M, Mangelsdorf, D.J. 登録日 2003-05-20 公開日 2003-06-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell(Cambridge,Mass.), 113, 2003
3RZZ	Structure of Hydroxyethylphoshphonate Dioxygenase Y98F Mutant 分子名称: CADMIUM ION, Hydroxyethylphoshphonate Dioxygenase (PhpD) 著者 Cooke, H.A. 登録日 2011-05-12 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase. Biochemistry, 50, 2011
3TY0	Structure of PPARgamma ligand binding domain in complex with (R)-5-(3-((3-(6-methoxybenzo[d]isoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-5-methyloxazolidine-2,4-dione 分子名称: (5R)-5-(3-{[3-(6-methoxy-1,2-benzoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]methyl}phenyl)-5-methyl-1,3-oxazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma 著者 Soisson, S.M, Meinke, P.M, McKeever, B, Liu, W. 登録日 2011-09-23 公開日 2011-11-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulators. J.Med.Chem., 54, 2011
3U31	Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine 分子名称: GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Transcriptional regulatory protein sir2 homologue, ... 著者 Zhou, Y, Hao, Q. 登録日 2011-10-04 公開日 2011-11-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine Acs Chem.Biol., 2011
3WT5	A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group 分子名称: (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Anami, Y, Itoh, T, Yamamoto, K. 登録日 2014-04-08 公開日 2014-06-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group. J.Med.Chem., 57, 2014
3WMH	Human PPAR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75 分子名称: N-(phenylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma 著者 Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M. 登録日 2013-11-19 公開日 2014-11-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human PPRR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75 TO BE PUBLISHED
3WTQ	Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3 分子名称: (1R,3R,7E,17beta)-17-[(2R,3S)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Nakabayashi, M, Inaba, Y, Itoh, T, Anami, Y, Ikura, T, Ito, N, Yamamoto, K. 登録日 2014-04-15 公開日 2015-04-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3 To be Published
6ZCE	Structure of a yeast ABCE1-bound 43S pre-initiation complex 分子名称: 18S ribosomal RNA (1719-MER), 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... 著者 Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. 登録日 2020-06-10 公開日 2020-10-07 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (5.3 Å) 主引用文献 A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. Embo J., 40, 2021
5IRG	Reverse transcriptase domain of group II intron maturase from Roseburia intestinalis in P212121 space group 分子名称: POTASSIUM ION, Retron-type reverse transcriptase 著者 Zhao, C, Pyle, A.M. 登録日 2016-03-13 公開日 2016-05-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat.Struct.Mol.Biol., 23, 2016
8P8H	Crystal structure of HHD2 domain of hRTEL1 分子名称: Regulator of telomere elongation helicase 1 著者 Hegde, R.P, Kanade, M, Cortone, G, Graewert, M, Longo, A, Gonzalez, A, Chaves-Arquero, B, Blanco, F.J, Napolitano, L.M.R, Onesti, S. 登録日 2023-06-01 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of HHD2 domain of hRTEL1 To Be Published
7M0V	Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. 登録日 2021-03-11 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
7M0W	Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide, ... 著者 Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. 登録日 2021-03-11 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
8P7C	CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry 分子名称: MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, Serine tRNA, ... 著者 Throll, P, Dolce, L.G, Kowalinski, E. 登録日 2023-05-30 公開日 2024-06-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of tRNA recognition by the m 3 C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. Nat.Struct.Mol.Biol., 2024
7M0U	Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib 分子名称: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. 登録日 2021-03-11 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
7M0T	Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. 登録日 2021-03-11 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
6TU5	Influenza A/H7N9 polymerase core (apo) 分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Pflug, A. 登録日 2020-01-02 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.325 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus 分子名称: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL 著者 Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
5F6W	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) 分子名称: 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 著者 Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. 登録日 2015-12-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
6ZFG	14-3-3 zeta chimera with 18E6 and fusicoccin 分子名称: 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL 著者 Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
3W52	Zinc-dependent bifunctional nuclease 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Endonuclease 2, ... 著者 Chou, T.L, Ko, T.P, Ko, C.Y, Shaw, J.F, Wang, A.H.J. 登録日 2013-01-18 公開日 2013-04-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Mechanistic insights to catalysis by a zinc-dependent bi-functional nuclease from Arabidopsis thaliana BIOCATAL AGRIC BIOTECHNOL, 2013
8F47	Crystal structure of VACV D13 in complex with STK69439 分子名称: 6,8-dimethoxy-2-methylquinolin-4-amine, FORMIC ACID, Scaffold protein D13 著者 Subedi, B.P, Garriga, D, Coulibaly, F. 登録日 2022-11-10 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of scaffolidng protein D13 of Vaccinia Virus in complex with fragments inhibiting A17 binding. To Be Published
5F3A	Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14 分子名称: ATPase family AAA domain-containing protein 2, SULFATE ION, ~{N}-(4-ethanoyl-1,3-thiazol-2-yl)azetidin-1-ium-3-carboxamide 著者 Dong, J, Caflisch, A. 登録日 2015-12-02 公開日 2016-12-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14 To Be Published
8F65	Crystal structure of VACV D13 in complex with BBL030900 分子名称: 8-methoxyquinolin-4-amine, FORMIC ACID, Scaffold protein D13 著者 Subedi, B.P, Garriga, D, Coulibaly, F. 登録日 2022-11-16 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure of scaffolidng protein D13 of Vaccinia Virus in complex with fragments inhibiting A17 binding. To Be Published
8CMZ	Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A 分子名称: COENZYME A, ZINC ION, histone acetyltransferase 著者 Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F. 登録日 2023-02-21 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.252 Å) 主引用文献 Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A To Be Published
8CN0	Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A 分子名称: COENZYME A, ZINC ION, histone acetyltransferase 著者 Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F. 登録日 2023-02-21 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A To Be Published

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