PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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1R6A	Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate 分子名称: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B. 登録日 2003-10-15 公開日 2004-09-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J.Biol.Chem., 279, 2004
4JU4	Crystal structure of hcv ns5b polymerase in complex with compound 22 分子名称: 2-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-5-phenoxybenzoic acid, Genome polyprotein, MAGNESIUM ION 著者 Coulombe, R. 登録日 2013-03-24 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay. Bioorg.Med.Chem.Lett., 23, 2013
4J02	Crystal structure of hcv ns5b polymerase in complex with [(1R)-5,8-DICHLORO-1-PROPYL-1,3,4,9-TETRAHYDROPYRANO[3,4-B]INDOL-1-YL]ACETIC ACID 分子名称: Genome polyprotein, SODIUM ION, SULFATE ION, ... 著者 Coulombe, R. 登録日 2013-01-30 公開日 2013-04-17 最終更新日 2013-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
1UA0	Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase 分子名称: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... 著者 Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. 登録日 2004-08-11 公開日 2004-09-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
4J06	Crystal structure of hcv ns5b polymerase in complex with 2-{[(5-BROMOTHIOPHEN-2-YL)SULFONYL]AMINO}-4-CHLOROBENZOIC ACID 分子名称: 2-{[(5-bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid, Genome polyprotein 著者 Coulombe, R. 登録日 2013-01-30 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
4J04	Crystal structure of hcv ns5b polymerase in complex with 4-CHLORO-2-{[(2,4,5-TRICHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 分子名称: 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid, Genome polyprotein, MANGANESE (II) ION 著者 Coulombe, R. 登録日 2013-01-30 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
4J08	Crystal structure of hcv ns5b polymerase in complex with 2-{[(4-METHYLPHENYL)SULFONYL]AMINO}-5-PHENOXYBENZOIC ACID 分子名称: 2-{[(4-methylphenyl)sulfonyl]amino}-5-phenoxybenzoic acid, Genome polyprotein 著者 Coulombe, R. 登録日 2013-01-30 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
1UA1	Structure of aminofluorene adduct paired opposite cytosine at the polymerase active site. 分子名称: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... 著者 Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. 登録日 2004-08-11 公開日 2004-09-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
4J0A	Crystal structure of hcv ns5b polymerase in complex with 2-{[(4-METHYLPHENYL)SULFONYL]AMINO}-4-PHENOXYBENZOIC ACID 分子名称: 2-{[(4-methylphenyl)sulfonyl]amino}-4-phenoxybenzoic acid, Genome polyprotein 著者 Coulombe, R. 登録日 2013-01-30 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
4ZN1	Crystal Structure of MjSpt4:Spt5 complex conformation A 分子名称: Transcription elongation factor Spt4, Transcription elongation factor Spt5, ZINC ION 著者 Guo, G.R, Zhou, H.H, Gao, Y.X, Zhu, Z.L, Niu, L.W, Teng, M.K. 登録日 2015-05-04 公開日 2016-03-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII J.Struct.Biol., 192, 2015
7DFG	Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir 分子名称: 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ... 著者 Li, Z, Zhou, Z, Yu, X. 登録日 2020-11-08 公開日 2021-11-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published
4ZN3	Crystal Structure of MjSpt4:Spt5 complex conformation B 分子名称: FE (III) ION, GLYCEROL, Transcription elongation factor Spt4, ... 著者 Guo, G.R, Zhou, H.H, Gao, Y.X, Zhu, Z.L, Niu, L.W, Teng, M.K. 登録日 2015-05-04 公開日 2016-03-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII J.Struct.Biol., 192, 2015
6OIT	CryoEM structure of Arabidopsis DDR' complex (DRD1 peptide-DMS3-RDM1) 分子名称: Protein CHROMATIN REMODELING 35, Protein DEFECTIVE IN MERISTEM SILENCING 3, Protein RDM1 著者 Wongpalee, S.P, Liu, S, Zhou, Z.H, Jacobsen, S.E. 登録日 2019-04-09 公開日 2019-07-24 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nat Commun, 10, 2019
7AAV	Human pre-Bact-2 spliceosome core structure 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-04 公開日 2020-12-09 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
5AFQ	Crystal structure of RPC62 - RPC32 beta 分子名称: DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3, RPC32 BETA (RPC7L) 著者 Fribourg, S. 登録日 2015-01-23 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (7 Å) 主引用文献 Structural Analysis of Human Rpc32Beta - Rpc62 Complex. J.Struct.Biol., 192, 2015
4EXT	Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta 分子名称: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit 著者 Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S. 登録日 2012-05-01 公開日 2013-05-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain To be Published
8J5Y	Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery 分子名称: LAS1 isoform 1, Polynucleotide 5'-hydroxyl-kinase GRC3 著者 Chen, J, Chen, H, Li, S, Lin, X, Hu, R, Zhang, K, Liu, L. 登録日 2023-04-24 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Elife, 12, 2024
1LV5	Crystal Structure of the Closed Conformation of Bacillus DNA Polymerase I Fragment Bound to DNA and dCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*TP*CP*GP*CP*TP*GP*AP*TP*CP*CP*G)-3', 5'-D(*GP*GP*AP*TP*CP*AP*GP*CP*GP*A)-3', ... 著者 Johnson, S.J, Taylor, J.S, Beese, L.S. 登録日 2002-05-24 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations Proc.Natl.Acad.Sci.USA, 100, 2003
6OIS	CryoEM structure of Arabidopsis DR complex (DMS3-RDM1) 分子名称: Protein DEFECTIVE IN MERISTEM SILENCING 3, Protein RDM1 著者 Wongpalee, S.P, Liu, S, Zhou, Z.H, Jacobsen, S.E. 登録日 2019-04-09 公開日 2019-07-24 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nat Commun, 10, 2019
4FJO	Structure of the Rev1 CTD-Rev3/7-Pol kappa RIR complex 分子名称: DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... 著者 Wojtaszek, J, Lee, C.-J, Zhou, P. 登録日 2012-06-11 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.718 Å) 主引用文献 Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric Pol zeta and Pol kappa J.Biol.Chem., 287, 2012
8E86	Human DNA polymerase eta-DNA-rC-ended primer-dGMPNPP ternary mismatch complex with Mn2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E87	Human DNA polymerase eta-DNA-rA-ended primer-dGMPNPP ternary mismatch complex with Mg2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8J	Human DNA polymerase eta-DNA-rG-ended primer-dGMPNPP ternary mismatch complex with Mg2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*CP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8B	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8G	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 180s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023

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