1IQJ
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![BU of 1iqj by Molmil](/molmil-images/mine/1iqj) | Human coagulation factor Xa in complex with M55124 | 分子名称: | 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-07-23 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published
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8GO7
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![BU of 8go7 by Molmil](/molmil-images/mine/8go7) | Fungal immunomodulatory protein FIP-nha N5+39A | 分子名称: | Fungal immunomodulatory protein FIP-nha | 著者 | Liu, Y, Bastiaan-Net, S, Hoppenbrouwers, T, Li, Z, Wichers, H.J. | 登録日 | 2022-08-24 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ). Molecules, 28, 2023
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8GO6
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![BU of 8go6 by Molmil](/molmil-images/mine/8go6) | Fungal immunomodulatory protein FIP-nha N39A | 分子名称: | fungal immunomodulatory protein FIP-nha N39A | 著者 | Liu, Y, Bastiaan-Net, S, Hoppenbrouwers, T, Li, Z, Wichers, H.J. | 登録日 | 2022-08-24 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.813 Å) | 主引用文献 | Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ). Molecules, 28, 2023
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8GO5
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![BU of 8go5 by Molmil](/molmil-images/mine/8go5) | |
1IQE
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![BU of 1iqe by Molmil](/molmil-images/mine/1iqe) | Human coagulation factor Xa in complex with M55590 | 分子名称: | 4-[(2R)-3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-1-OXO-2-[[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]AMINO]PROPYL]-THIOMORPHOLINE-1,1-DIOXIDE, CALCIUM ION, coagulation Factor Xa | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-07-23 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published
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1IQM
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![BU of 1iqm by Molmil](/molmil-images/mine/1iqm) | Human coagulation factor Xa in complex with M54471 | 分子名称: | 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE, CALCIUM ION, coagulation Factor Xa | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-07-23 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published
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1IQK
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![BU of 1iqk by Molmil](/molmil-images/mine/1iqk) | Human coagulation factor Xa in complex with M55113 | 分子名称: | 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-07-23 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published
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1HGT
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![BU of 1hgt by Molmil](/molmil-images/mine/1hgt) | |
1H1B
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![BU of 1h1b by Molmil](/molmil-images/mine/1h1b) | Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151) | 分子名称: | (2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID, LEUKOCYTE ELASTASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Macdonald, S.J.F, Dowle, M.D, Harrison, L.A, Clarke, G.D.E, Inglis, G.G.A, Johnson, M.R, Smith, R.A, Amour, A, Fleetwood, G, Humphreys, D.C, Molloy, C.R, Dixon, M, Godward, R.E, Wonacott, A.J, Singh, O.M.P, Hodgson, S.T, Hardy, G.W. | 登録日 | 2002-07-05 | 公開日 | 2002-08-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151) J.Med.Chem., 45, 2002
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1HAH
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![BU of 1hah by Molmil](/molmil-images/mine/1hah) | THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ... | 著者 | Tulinsky, A, Vijayalakshmi, J. | 登録日 | 1994-06-27 | 公開日 | 1994-12-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci., 3, 1994
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8HFM
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8HFO
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![BU of 8hfo by Molmil](/molmil-images/mine/8hfo) | Crystal Structure of Mycobacterium smegmatis MshC in Complex with Compound 7d | 分子名称: | CALCIUM ION, L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, N-[(3M)-3-(thiophen-2-yl)benzene-1-sulfonyl]-L-cysteinamide, ... | 著者 | Pang, L, Weeks, S.D, Strelkov, S.V. | 登録日 | 2022-11-11 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. Int J Mol Sci, 23, 2022
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8HFN
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![BU of 8hfn by Molmil](/molmil-images/mine/8hfn) | Crystal Structure of Mycobacterium smegmatis MshC in Complex with Compound 7b | 分子名称: | CALCIUM ION, L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, N-[(3M)-3-(6-methoxypyridin-3-yl)benzene-1-sulfonyl]-L-cysteinamide, ... | 著者 | Pang, L, Weeks, S.D, Strelkov, S.V. | 登録日 | 2022-11-11 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. Int J Mol Sci, 23, 2022
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1HXE
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![BU of 1hxe by Molmil](/molmil-images/mine/1hxe) | SERINE PROTEASE | 分子名称: | HIRUDIN VARIANT-1, RUBIDIUM ION, THROMBIN | 著者 | Tulinsky, A, Zhang, E. | 登録日 | 1995-12-07 | 公開日 | 1996-11-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The molecular environment of the Na+ binding site of thrombin. Biophys.Chem., 63, 1997
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1HV7
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![BU of 1hv7 by Molmil](/molmil-images/mine/1hv7) | PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A | 分子名称: | ELASTASE 1, N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE, SULFATE ION | 著者 | Skarzynski, T, Singh, O.M. | 登録日 | 2001-01-08 | 公開日 | 2001-01-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate Bioorg.Med.Chem.Lett., 11, 2001
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1IOE
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![BU of 1ioe by Molmil](/molmil-images/mine/1ioe) | Human coagulation factor Xa in complex with M55532 | 分子名称: | (-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE, CALCIUM ION, COAGULATION FACTOR XA | 著者 | Shiromizu, I, Matsusue, T. | 登録日 | 2001-03-08 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa To be Published
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1IHT
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![BU of 1iht by Molmil](/molmil-images/mine/1iht) | |
1IHS
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![BU of 1ihs by Molmil](/molmil-images/mine/1ihs) | |
1INC
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1J9C
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![BU of 1j9c by Molmil](/molmil-images/mine/1j9c) | Crystal Structure of tissue factor-factor VIIa complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ... | 著者 | Huang, M, Ruf, W, Edgington, T.S, Wilson, I.A. | 登録日 | 2001-05-24 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Ligand Induced Conformational Transitions of Tissue Factor. Crystal Structure of the Tissue Factor:Factor VIIa Complex. To be Published
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1FZZ
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![BU of 1fzz by Molmil](/molmil-images/mine/1fzz) | THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE. | 分子名称: | 2-(5-AMINO-6-OXO-2-PHENYL-6H-PYRIMIDIN-1-YL)-N-[2-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)-1-(METHYLETHYL)-2-HYDROXYETHYL]ACETAMIDE, ELASTASE 1 | 著者 | Odagaki, Y, Ohmoto, K, Matsuoka, S, Hamanaka, N, Nakai, H, Toda, M, Katsuya, Y. | 登録日 | 2000-10-04 | 公開日 | 2001-10-04 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase. Bioorg.Med.Chem., 9, 2001
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1G32
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![BU of 1g32 by Molmil](/molmil-images/mine/1g32) | THROMBIN INHIBITOR COMPLEX | 分子名称: | 4-{[1-METHYL-5-(2-METHYL-BENZOIMIDAZOL-1-YLMETHYL)-1H-BENZOIMIDAZOL-2-YLMETHYL]-AMINO}-BENZAMIDINE, HIRUDIN IIB, PROTHROMBIN | 著者 | Nar, H. | 登録日 | 2000-10-23 | 公開日 | 2001-10-23 | 最終更新日 | 2013-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors. Structure, 9, 2001
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1GBA
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1GBJ
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![BU of 1gbj by Molmil](/molmil-images/mine/1gbj) | ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA | 分子名称: | ALPHA-LYTIC PROTEASE, SULFATE ION | 著者 | Mace, J.E, Agard, D.A. | 登録日 | 1995-09-06 | 公開日 | 1996-01-29 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J.Mol.Biol., 254, 1995
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1GBE
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![BU of 1gbe by Molmil](/molmil-images/mine/1gbe) | |