7EJO
 
 | | Structure of ERH-2 bound to TOST-1 | | 分子名称: | Enhancer of rudimentary homolog 2, Enhancer of rudimentary homolog 2,Protein tost-1 | | 著者 | Wang, X, Xu, C. | | 登録日 | 2021-04-02 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.191 Å) | | 主引用文献 | Molecular basis for PICS-mediated piRNA biogenesis and cell division.
Nat Commun, 12, 2021
|
|
7E56
 | |
7DUF
 | | Crystal structure of VIM1 PHD finger. | | 分子名称: | E3 ubiquitin-protein ligase ORTHRUS 2, ZINC ION | | 著者 | Abhishek, S, Deeksha, W, Patel, D.J, Rajakumara, E. | | 登録日 | 2021-01-08 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Helical and beta-Turn Conformations in the Peptide Recognition Regions of the VIM1 PHD Finger Abrogate H3K4 Peptide Recognition.
Biochemistry, 60, 2021
|
|
5KSR
 | | Stationary phase survival protein E (SurE) from Xylella fastidiosa - XFSurE-TB (Tetramer Bigger). | | 分子名称: | 5'-nucleotidase SurE, CHLORIDE ION, IODIDE ION, ... | | 著者 | Machado, A.T.P, Fonseca, E.M.B, Dos Reis, M.A, Saraiva, A.M, Dos Santos, C.A, De Toledo, M.A, Polikarpov, I, De Souza, A.P, De Aparicio, R, Iulek, J. | | 登録日 | 2016-07-09 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Conformational variability of the stationary phase survival protein E from Xylella fastidiosa revealed by X-ray crystallography, small-angle X-ray scattering studies, and normal mode analysis.
Proteins, 85, 2017
|
|
2Z9G
 | |
2ZK4
 | | Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid | | 分子名称: | (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Waku, T, Shiraki, T, Oyama, T, Fujimoto, Y, Morikawa, K. | | 登録日 | 2008-03-12 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids
J.Mol.Biol., 385, 2009
|
|
2MJN
 | |
7K3Z
 | |
7KCC
 | | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270 | | 分子名称: | 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ... | | 著者 | Padyana, A, Jin, L. | | 登録日 | 2020-10-05 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
|
|
3HF5
 | | Crystal structure of 4-methylmuconolactone methylisomerase in complex with 3-methylmuconolactone | | 分子名称: | 4-methylmuconolactone methylisomerase, [(2S)-3-methyl-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | 著者 | Marin, M, Heinz, D.W, Pieper, D.H, Klink, B.U. | | 登録日 | 2009-05-11 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase
J.Biol.Chem., 284, 2009
|
|
3HFK
 | | Crystal structure of 4-methylmuconolactone methylisomerase (H52A) in complex with 4-methylmuconolactone | | 分子名称: | 4-methylmuconolactone methylisomerase, [(2S)-2-methyl-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | 著者 | Marin, M, Heinz, D.W, Pieper, D.H, Klink, B.U. | | 登録日 | 2009-05-12 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase
J.Biol.Chem., 284, 2009
|
|
8OO8
 | |
7Q1Y
 | | X-ray structure of human A2ML1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... | | 著者 | Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. | | 登録日 | 2021-10-22 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
|
|
7EDJ
 | | Cryo-EM structure of SARS-CoV-2 S-UK variant (B.1.1.7) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2 (ACE2) ectodomain, ... | | 著者 | Yang, T.J, Yu, P.Y, Chang, Y.C, Wu, H.C, Hsu, S.T.D. | | 登録日 | 2021-03-16 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-01-05 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7AII
 | | HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE | | 分子名称: | DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ... | | 著者 | Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. | | 登録日 | 2020-09-27 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues.
J.Med.Chem., 64, 2021
|
|
8OQY
 | | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | | 登録日 | 2023-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform.
Nat Commun, 15, 2024
|
|
7DY8
 | | Thermotoga maritima ferritin mutant-FLAL | | 分子名称: | CALCIUM ION, FE (III) ION, Ferritin | | 著者 | Zhang, X, Zhao, G. | | 登録日 | 2021-01-20 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials.
Nat Commun, 12, 2021
|
|
7PZD
 | | Cryo-EM structure of the NLRP3 PYD filament | | 分子名称: | NACHT, LRR and PYD domains-containing protein 3 | | 著者 | Hochheiser, I.V, Hagelueken, G, Behrmann, H, Behrmann, E, Geyer, M. | | 登録日 | 2021-10-12 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.
Sci Adv, 8, 2022
|
|
7JTR
 | |
2MO5
 | | hIFABP-oleate complex | | 分子名称: | Fatty acid-binding protein, intestinal, OLEIC ACID | | 著者 | Patil, R, Mohanty, B, Headey, S, Porter, C, Scanlon, M. | | 登録日 | 2014-04-17 | | 公開日 | 2015-04-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of oleate bound human intestinal fatty acid binding protein
To be Published
|
|
7K5J
 | | Structure of an E1-E2-ubiquitin thioester mimetic | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | | 著者 | Yuan, L, Lv, Z, Olsen, S.K. | | 登録日 | 2020-09-16 | | 公開日 | 2021-04-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification.
Nat Commun, 12, 2021
|
|
8OZ7
 | |
7AO2
 | | Crystal structure of CotB2 variant W288G in complex with alendronate | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, CHLORIDE ION, ... | | 著者 | Dimos, N, Driller, R, Loll, B. | | 登録日 | 2020-10-13 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol.
J.Am.Chem.Soc., 142, 2020
|
|
3HH2
 | |
7DYB
 | | Thermotoga maritima ferritin mutant-FLAL-L | | 分子名称: | FE (III) ION, Ferritin | | 著者 | Zhao, G, Zhang, X. | | 登録日 | 2021-01-20 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.779 Å) | | 主引用文献 | Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials.
Nat Commun, 12, 2021
|
|
