PDB: 4080 件ウェブページステータス検索Chemie searchBIRD

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1QUR	HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR 分子名称: BIVALENT INHIBITOR (BZA-2 HIRULOG), HUMAN THROMBIN (ALPHA CHAIN), HUMAN THROMBIN (BETA CHAIN) 著者 Renatus, M, Steinmetzer, T. 登録日 1999-07-02 公開日 1999-10-14 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines. Eur.J.Biochem., 265, 1999
7NE4	E125A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 分子名称: Oligopeptidase B, SPERMINE 著者 Petrenko, D.E, Nikolaeva, A.Y, Lazarenko, V.A, Dorovatovskiy, P.V, Vlaskina, A.V, Mikhailova, A.G, Rakitina, T.V, Timofeev, V.I. 登録日 2021-02-03 公開日 2021-03-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.717 Å) 主引用文献 First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine. Biology (Basel), 10, 2021
7NE5	catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 分子名称: Oligopeptidase B, SPERMINE 著者 Petrenko, D.E, Nikolaeva, A.Y, Lazarenko, V.A, Dorovatovskiy, P.V, Vlaskina, A.V, Mikhailova, A.G, Rakitina, T.V, Timofeev, V.I. 登録日 2021-02-03 公開日 2021-03-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine. Biology (Basel), 10, 2021
7OB1	OLIGOPEPTIDASE B FROM S. PROTEOMACULANS WITH MODIFIED HINGE 分子名称: Oligopeptidase B, SPERMINE 著者 Petrenko, D.E, Nikolaeva, A.Y, Lazarenko, V.A, Dorovatovskiy, P.V, Vlaskina, A.V, Korzhenevskiy, D.A, Mikhailova, A.G, Rakitina, T.V, Timofeev, V.I. 登録日 2021-04-20 公開日 2021-05-19 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine. Biology (Basel), 10, 2021
7SGJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711 分子名称: 1,2-ETHANEDIOL, 4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide, DI(HYDROXYETHYL)ETHER, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2021-10-05 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGI	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14 分子名称: 5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2021-10-05 公開日 2022-10-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGG	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA 分子名称: DI(HYDROXYETHYL)ETHER, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, PHOSPHATE ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2021-10-05 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7SGK	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728 分子名称: N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2021-10-05 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144, 2022
7S3V	Structure of HsKYNase_66, an evolved variant of human kynureninase with greatly increased activity towards kynurenine 分子名称: Kynureninase 著者 Burkholder, N.T, Zhang, Y.J. 登録日 2021-09-08 公開日 2022-12-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.249 Å) 主引用文献 Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme. Nat Catal, 5, 2022
1IAU	HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GRANZYME B, ... 著者 Rotonda, J, Garcia-Calvo, M, Bull, H.G, Geissler, W.M, McKeever, B.M, Willoughby, C.A, Thornberry, N.A, Becker, J.W. 登録日 2001-03-23 公開日 2001-05-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem.Biol., 8, 2001
4JSQ	Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4e 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable proteasome subunit alpha type-7, Proteasome subunit alpha type-1, ... 著者 Desvergne, A, Genin, E, Marechal, X, Gallastegui, N, Dufau, L, Richy, N, Groll, M, Vidal, J, Reboud-Ravaux, M. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome J.Med.Chem., 56, 2013
4JT0	Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:4a 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable proteasome subunit alpha type-7, Proteasome subunit alpha type-1, ... 著者 Desvergne, A, Genin, E, Marechal, X, Gallastegui, N, Dufau, L, Richy, N, Groll, M, Vidal, J, Reboud-Ravaux, M. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome. J.Med.Chem., 56, 2013
1HIA	KALLIKREIN COMPLEXED WITH HIRUSTASIN 分子名称: HIRUSTASIN, KALLIKREIN 著者 Mittl, P, Di Marco, S, Gruetter, M. 登録日 1996-12-12 公開日 1997-12-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex. Structure, 5, 1997
4JSU	Yeast 20S proteasome in complex with the dimerized linear mimetic of TMC-95A - yCP:3a 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable proteasome subunit alpha type-7, Proteasome subunit alpha type-1, ... 著者 Desvergne, A, Genin, E, Marechal, X, Gallastegui, N, Dufau, L, Richy, N, Groll, M, Vidal, J, Reboud-Ravaux, M. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome J.Med.Chem., 56, 2013
1QIX	Porcine pancreatic elastase complexed with human beta-casomorphin-7 分子名称: BETA-CASOMORPHIN-7, CALCIUM ION, ELASTASE, ... 著者 Wilmouth, R.C, Clifton, I.J, Hajdu, J, Schofield, C.J. 登録日 1999-06-18 公開日 1999-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a Specific Acyl-Enzyme Complex Formed between Beta-Casomorphin-7 and Porcine Pancreatic Elastase Nat.Struct.Biol., 4, 1997
6XHZ	Alpha-lytic protease homolog N4 分子名称: N4: hypothetical protein, SULFATE ION 著者 Nixon, C.F, Marqusee, S.M, Gee, C.L. 登録日 2020-06-19 公開日 2021-01-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Exploring the Evolutionary History of Kinetic Stability in the alpha-Lytic Protease Family. Biochemistry, 60, 2021
6Y3B	Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2110 分子名称: 1-[(8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, GLYCEROL, Genome polyprotein, ... 著者 Huber, S, Heine, A, Steinmetzer, T. 登録日 2020-02-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses. Chemmedchem, 15, 2020
4Z8N	Crystal structure of the erythrocyte-binding domain from Plasmodium vivax reticulocyte-binding protein 2a (PvRBP2a) 分子名称: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Gruszczyk, J, Tham, W.H. 登録日 2015-04-09 公開日 2015-12-16 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.124 Å) 主引用文献 Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. Proc.Natl.Acad.Sci.USA, 113, 2016
8OYH	X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol 分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Dahms, S.O, Brandstetter, H. 登録日 2023-05-04 公開日 2024-03-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19, 2024
2XW9	Crystal Structure of Complement Factor D mutant S183A 分子名称: COMPLEMENT FACTOR D, GLYCEROL 著者 Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. 登録日 2010-11-01 公開日 2011-01-12 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
5A53	Crystal Structure of the Rpf2-Rrs1 complex 分子名称: REGULATOR OF RIBOSOME BIOSYNTHESIS, RIBOSOME BIOGENESIS PROTEIN RPF2, SULFATE ION 著者 Madru, C, Lebaron, S, Blaud, M, Delbos, L, Rety, S, Leulliot, N. 登録日 2015-06-16 公開日 2015-10-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Chaperoning 5S RNA Assembly. Genes Dev., 29, 2015
7Q8I	Peptide AVAEKQ in complex with human cathepsin V C25S mutant 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, AVAEKQ peptide, CHLORIDE ION, ... 著者 Loboda, J, Sosnowski, P, Tusar, L, Vidmar, R, Vizovisek, M, Horvat, J, Kosec, G, Impens, F, Demol, H, Turk, B, Gevaert, K, Turk, D. 登録日 2021-11-11 公開日 2022-11-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Commun Biol, 6, 2023
7Q8O	Peptide LLSGKE in complex with human cathepsin V C25S mutant 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cathepsin L2, ... 著者 Loboda, J, Sosnowski, P, Tusar, L, Vidmar, R, Vizovisek, M, Horvat, J, Kosec, G, Impens, F, Demol, H, Turk, B, Gevaert, K, Turk, D. 登録日 2021-11-11 公開日 2022-11-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Commun Biol, 6, 2023
7Q8H	Peptide EVCKKKK in complex with human cathepsin V C25A mutant 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cathepsin L2, ... 著者 Loboda, J, Sosnowski, P, Tusar, L, Vidmar, R, Vizovisek, M, Horvat, J, Kosec, G, Impens, F, Demol, H, Turk, B, Gevaert, K, Turk, D. 登録日 2021-11-11 公開日 2022-11-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Commun Biol, 6, 2023
7Q9H	Peptide LLKAVAEKQ in complex with human cathepsin V C25A mutant 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cathepsin L2, ... 著者 Loboda, J, Sosnowski, P, Tusar, L, Vidmar, R, Vizovisek, M, Horvat, J, Kosec, G, Impens, F, Demol, H, Turk, B, Gevaert, K, Turk, D. 登録日 2021-11-12 公開日 2022-11-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Commun Biol, 6, 2023

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