2P2R
 
 | | Crystal structure of the third KH domain of human Poly(C)-Binding Protein-2 in complex with C-rich strand of human telomeric DNA | | 分子名称: | 6-AMINOPYRIMIDIN-2(1H)-ONE, C-rich strand of human telomeric DNA, Poly(rC)-binding protein 2 | | 著者 | James, T.L, Stroud, R.M, Du, Z, Fenn, S, Tjhen, R, Lee, J.K. | | 登録日 | 2007-03-07 | | 公開日 | 2007-06-12 | | 最終更新日 | 2019-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.
Nucleic Acids Res., 35, 2007
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4CI2
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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2PA2
 | | Crystal structure of human Ribosomal protein L10 core domain | | 分子名称: | 60S ribosomal protein L10, POTASSIUM ION | | 著者 | Nishimura, M, Kaminishi, T, Takemoto, C, Kawazoe, M, Yoshida, T, Tanaka, A, Sugano, S, Shirouzu, M, Ohkubo, T, Yokoyama, S, Kobayashi, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-03-27 | | 公開日 | 2008-03-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Human Ribosomal Protein L10 Core Domain Reveals Eukaryote-Specific Motifs in Addition to the Conserved Fold
J.Mol.Biol., 377, 2008
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7NV1
 | | Human Pol Kappa holoenzyme with Ub-PCNA | | 分子名称: | DNA Primer, DNA Template, DNA polymerase kappa, ... | | 著者 | Lancey, C, De Biasio, A, Hamdan, S.M. | | 登録日 | 2021-03-15 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
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7NV0
 | | Human Pol Kappa holoenzyme with wt PCNA | | 分子名称: | DNA Primer, DNA Template, DNA polymerase kappa, ... | | 著者 | Lancey, C, De Biasio, A, Hamdan, S.M. | | 登録日 | 2021-03-15 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
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3D2W
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4D5Y
 | | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state | | 分子名称: | 28S Ribosomal RNA, 5.8S Ribosomal RNA, 5S Ribosomal RNA, ... | | 著者 | Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T. | | 登録日 | 2014-11-07 | | 公開日 | 2015-03-04 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Cryo-Em Structures of Ribosomal 80S Complexes with Termination Factors and Cricket Paralysis Virus Ires Reveal the Ires in the Translocated State
Mol.Cell, 57, 2015
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7P9V
 | | Cryo EM structure of System XC- | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2021-07-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
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7P9U
 | | Cryo EM structure of System XC- in complex with glutamate | | 分子名称: | 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2021-07-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
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2P9S
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4CY1
 | | Crystal structure of the KANSL1-WDR5 complex. | | 分子名称: | GLYCEROL, KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, WD REPEAT-CONTAINING PROTEIN 5 | | 著者 | Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. | | 登録日 | 2014-04-09 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex.
Genes Dev., 28, 2014
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3D2K
 | | Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with [7-(2-{2-[3-(3-chloro-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid | | 分子名称: | (7-{[2-(2-{[(3-chlorophenyl)carbamoyl]amino}-1,3-thiazol-5-yl)ethyl]amino}-1H-pyrazolo[4,3-d]pyrimidin-1-yl)acetic acid, serine/threonine kinase 6 | | 著者 | Elling, R.A, Oslob, J.D, Yu, C, Romanowski, M.J. | | 登録日 | 2008-05-08 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of Aurora-A-selective inhibitors
To be Published
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4EWR
 | | X-ray structure of WDR5-SETd1a Win motif peptide binary complex | | 分子名称: | Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5 | | 著者 | Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. | | 登録日 | 2012-04-27 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.503 Å) | | 主引用文献 | Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
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4E5O
 | | Crystal structure of mouse thymidylate synthase in complex with dUMP | | 分子名称: | 1,4-BUTANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | | 著者 | Dowiercial, A, Jarmula, A, Rypniewski, W, Sokolowska, M, Fraczyk, T, Ciesla, J, Rode, W. | | 登録日 | 2012-03-14 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Struct Chem, 2016
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2P9L
 | | Crystal Structure of bovine Arp2/3 complex | | 分子名称: | Actin-like protein 2, Actin-like protein 3, Actin-related protein 2/3 complex subunit 1B, ... | | 著者 | Nolen, B.J, Pollard, T.D. | | 登録日 | 2007-03-26 | | 公開日 | 2007-05-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex.
Mol.Cell, 26, 2007
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2OU2
 | | Acetyltransferase domain of Human HIV-1 Tat interacting protein, 60kDa, isoform 3 | | 分子名称: | ACETYL COENZYME *A, Histone acetyltransferase HTATIP, ZINC ION | | 著者 | Min, J, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2007-02-09 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Crystal Structure of acetyltransferase domain of Human HIV-1 Tat interacting protein in complex with acetylcoenzyme A.
To be Published
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3DWH
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3DFT
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3DJ7
 | | Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 130. | | 分子名称: | 1-(5-{2-[(6-amino-5-bromopyrimidin-4-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea, serine/threonine kinase 6 | | 著者 | Elling, R.A, Yang, W, Erlanson, D.A, Tangonan, B.T, Hansen, S.K, Romanowski, M.J. | | 登録日 | 2008-06-22 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | New fragment-based drug discovery
To be Published
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2PX6
 | | Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat | | 分子名称: | (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Thioesterase domain | | 著者 | Pemble IV, C.W, Johnson, L.C, Kridel, S.J, Lowther, W.T. | | 登録日 | 2007-05-14 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Nat.Struct.Mol.Biol., 14, 2007
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4ESG
 | | X-ray structure of WDR5-MLL1 Win motif peptide binary complex | | 分子名称: | Histone-lysine N-methyltransferase MLL, WD repeat-containing protein 5 | | 著者 | Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. | | 登録日 | 2012-04-23 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
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4DRW
 | | Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide | | 分子名称: | Neuroblast differentiation-associated protein AHNAK, Protein S100-A10/Annexin A2 chimeric protein | | 著者 | Rezvanpour, A, Lee, T.-W, Junop, M.S, Shaw, G.S. | | 登録日 | 2012-02-17 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of an asymmetric ternary protein complex provides insight for membrane interaction.
Structure, 20, 2012
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3E1Y
 | | Crystal structure of human eRF1/eRF3 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Eukaryotic peptide chain release factor subunit 1 | | 著者 | Cheng, Z, Lim, M, Kong, C, Song, H. | | 登録日 | 2008-08-05 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural insights into eRF3 and stop codon recognition by eRF1
Genes Dev., 23, 2009
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3DJ5
 | | Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290. | | 分子名称: | 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide, serine/threonine kinase 6 | | 著者 | Elling, R.A, Erlanson, D.A, Yang, W, Tangonan, B.T, Hansen, S.K, Romanowski, M.J. | | 登録日 | 2008-06-22 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | New fragment-based drug discovery
To be Published
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7P3B
 | | Human RNA ligase RTCB in complex with GMP and Co(II) | | 分子名称: | ACETATE ION, COBALT (II) ION, FORMIC ACID, ... | | 著者 | Kroupova, A, Ackle, F, Jinek, M. | | 登録日 | 2021-07-07 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular architecture of the human tRNA ligase complex.
Elife, 10, 2021
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