4E5O

Crystal structure of mouse thymidylate synthase in complex with dUMP

Replaces:  3IHH

Summary for 4E5O

• Entry DOI: 10.2210/pdb4e5o/pdb
• Related: 3IHI
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 1,4-BUTANEDIOL, ... (4 entities in total)
• Functional Keywords: protein-ligand complex, methyltransferase, nucleotide biosynthesis, transferase
• Biological source: Mus musculus (mouse)
• Cellular location: Nucleus : P07607
• Total number of polymer chains: 6
• Total formula weight: 212433.73

Authors

Dowiercial, A.,Jarmula, A.,Rypniewski, W.,Sokolowska, M.,Fraczyk, T.,Ciesla, J.,Rode, W. (deposition date: 2012-03-14, release date: 2012-04-18, Last modification date: 2023-09-13)

• Primary citation: Dowiercial, A.,Jarmula, A.,Wilk, P.,Rypniewski, W.,Kowalska, M.,Fraczyk, T.,Ciesla, J.,Rode, W.; Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme; Struct Chem, 2016; DOI: 10.1007/s11224-016-0840-8

Experimental method

X-RAY DIFFRACTION (1.7 Å)